Browsing by Author "A. Jain"

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Clinicopathological profile and therapeutic appraisals in lymphoma in eastern Uttar Pradesh
(1997) V.P. Singh; S. Sundar; S. Gupta; B.L. Rastogi; M. Kumar; G.C. Pant; A. Jain; N. Gera
Ninety-four patients of lymphoma (55 of Non-Hodgkin's and 39 of Hodgkin's) were evaluated for clinical profile, histological subtypes and therapeutic outcome. Out of 94, 'B' symptoms were present in 66, lymphadenopathy in 82 and anaemia in 50 patients. Forty-three patients presented in stage IV. Mixed cellularity (53.8%) was the most common histologic subtype in Hodgkin's disease and diffuse mixed (30.5%) in non-Hodgkin's lymphoma. Initial complete remission rates as seen with chemotherapeutic regimes were 74.1% with COPP in Hodgkin's disease and 58.3% with CVP and 75% with CHOP in non-Hodgkin's lymphoma.
Deformation dependence of 2p-radioactivity half-lives: probe with a new formula across the mass region with Z < 82
(Institute of Physics, 2023) G. Saxena; Mamta Aggarwal; D. Singh; A. Jain; P.K. Sharma; H.L. Yadav
Effect of deformation on half-life of two-proton (2p) radioactivity is investigated across the periodic chart for nuclei with Z < 82. 2p-decay half-lives are estimated by employing our newly proposed semi-empirical formula wherein the nuclear deformation has been incorporated in a phenomenological way. Robustness of the formula is demonstrated as it estimates the measured values quite accurately and, hence, reliably applied to predict the other possible 2p-emitters. For many proton rich nuclei for which experimental data on the decay energies are not available, we have used the theoretical values obtained from our calculations using the relativistic mean-field approach. The uncertainties in the theoretical decay energy values are minimised by machine learning technique. Correlation of 2p-radioactivity with 2p-halo and deformation is probed. Our calculations show the phenomenon of shape coexistence in several 2p-emitters, wherein the prolate shape is found to be more predominant for the ground state. © 2022 IOP Publishing Ltd.
Development of repaglinide loaded solid lipid nanocarrier: Selection of fabrication method
(2010) M.K. Rawat; A. Jain; A. Mishra; M.S. Muthu; S. Singh
Repaglinide solid lipid nanoparticles (RG-SLN) were fabricated using stearic acid as lipid. Pluronic F68 (PLF68) and soya lecithin were used as a stabilizer. SLNs were prepared by modified solvent injection and ultrasonication methods. SLNs prepared with modified solvent injection method have larger particle size (360±2.5nm) than prepared with ultrasonication method (281±5.3nm). The zeta potential of the prepared formulations by these two methods varied from - 23.10 ±1.23 to -26.01 ±0.89 mV. The maximum entrapment efficiency (62.14 ±1.29%) was obtained in modified solvent injection method. The total drug content was nearly same (98%) in both the methods. In vitro release studies were performed in phosphate buffer (pH 6.8) with 0.5% sodium lauryl sulphate (SLS) using dialysis bag diffusion technique. The cumulative drug release was 30% and 50% within 2 hrs in modified solvent injection and ultrasonication method, respectively. This indicates that RG-SLN prepared from modified injection method released the drug more slowly than SLNs prepared with ultrasonication method. Differential scanning calorimetry indicates that repaglinide (RG) entrapped in the solid lipid nanoparticles (SLN) exist in an amorphous or molecular state. Repaglinide loaded solid lipid nanoparticles prepared with both methods were of spherical shape as observed by transmission electron microscopy (TEM). These results suggest that modified solvent injection method is more suitable for preparation of repaglinide SLNs using stearic acid. © 2010 Bentham Science Publishers Ltd.
Development of satranidazole mucoadhesive gel for the treatment of periodontitis
(2009) K. Bansal; M.K. Rawat; A. Jain; A. Rajput; T.P. Chaturvedi; S. Singh
The aim of the paper was to develop satranidazole-containing mucoadhesive gel for the treatment of periodontitis. Different mucoadhesive gels were prepared, using various gelling agents like sodium carboxymethylcellulose (SCMC), poloxamer 407, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, and the mucoadhesive polymer carbopol 934P. The selected formulations (based on the mucoadhesive force) were studied for different mechanical properties, such as mucoadhesive strength, hardness, compressibility, adhesiveness, and cohesiveness through Texture Profile Analyzer. In vitro satranidazole release from the prepared formulations was also determined and compared with marketed preparation of metronidazole (Metrogyl® gel). The formulation SC30 (containing SCMC 3% w/v) showed maximum mucoadhesive strength (167.72 ± 3.76 g) and adhesiveness (-46.23 ± 0.34 N∈mm), with low hardness (9.81 ± 0.04 N) and compressibility (40.05 ± 0.48 N∈mm) and moderate cohesiveness (0.87 ± 0.01). SC30 formulation exhibited long-term release. Thus, SC30 gel was evaluated for its clinical effectiveness along with marketed metronidazole gel. At the end of the study (42 days of clinical studies), both formulations were found to significantly reduce the probing depth, plaque index, gingival index, calculus criteria, and bleeding index. However, the SC30 gel was more effective in reducing the above parameters than marketed metronidazole gel. This study confirmed the acceptability and effectiveness of satranidazole gel for treatment of periodontitis. © 2009 American Association of Pharmaceutical Scientists.
Disciplined reactions' using phenyl isothiocyanate as a cyclocondensing agent. A novel one-flask synthesis of 2-substituted-4-m-methoxy-p-hydroxy-benzylidene-1-phenyl-2-imidazolin- 5-ones
(1990) A. Jain; A.K. Mukerjee
[No abstract available]
Microbial consortium-mediated reprogramming of defence network in pea to enhance tolerance against Sclerotinia sclerotiorum
(2012) A. Jain; S. Singh; B. Kumar Sarma; H. Bahadur Singh
Aims: To evaluate the potentiality of three rhizosphere microorganisms in suppression of Sclerotinia rot in pea in consortia mode and their impact on host defence responses. Methods and Results: Pseudomonas aeruginosa PJHU15, Trichoderma harzianum TNHU27 and Bacillus subtilis BHHU100 from rhizospheric soils were selected based on compatibility, antagonistic and plant growth promotion activities. The microbes were used as consortia to assess their ability to trigger the phenylpropanoid and antioxidant activities and accumulation of proline, total phenol and pathogenesis-related (PR) proteins in pea under the challenge of the soft-rot pathogen Sclerotinia sclerotiorum. The triple-microbe consortium and single-microbe treatments showed 1·4-2·3 and 1·1-1·7-fold increment in defence parameters, respectively, when compared to untreated challenged control. Activation of the phenylpropanoid pathway and accumulation of total phenolics were highest at 48h, whereas accumulation of proline and PR proteins along with activities of the antioxidant enzymes was highest at 72h. Conclusions: The compatible microbial consortia triggered defence responses in an enhanced level in pea than the microbes alone and provided better protection against Sclerotinia rot. Significance and Impact of the Study: Rhizosphere microbes in consortium can enhance protection in pea against the soft-rot pathogen through augmented elicitation of host defence responses. © 2011 The Authors. Journal of Applied Microbiology © 2011 The Society for Applied Microbiology.
One-pot conversion of 2-methyl-3,1-benzoxazin-4-one into 3-substituted 2-styrylquinazolin-4-ones
(1987) A. Jain; A.K. Mukerjee
[No abstract available]
Rhizosphere microbes facilitate redox homeostasis in Cicer arietinum against biotic stress
(2013) A. Singh; A. Jain; B.K. Sarma; R.S. Upadhyay; H.B. Singh
The aim of this study was to evaluate the potentiality of three compatible rhizosphere microbes, viz. fluorescent Pseudomonas aeruginosa (PHU094), Trichoderma harzianum (THU0816) and Mesorhizobium sp. (RL091), in community to mobilise antioxidant mechanisms in chickpea under the challenge of Sclerotium rolfsii. The microbes were applied as seed treatment in different combinations in two sets and the pathogen was inoculated in one of the sets after 3 weeks of sowing. A comparative study was conducted on the effect of the microbial combinations on host antioxidant mechanisms between the two sets. In pathogen challenged plants host defence responses included higher accumulation of hydrogen peroxide (H2O2) at petiolar and interveinal regions of leaf and high activities of catalase (CAT), glutathione reductase (GR) and guaiacol peroxidase (GPx) compared to unchallenged plants. The antioxidant enzyme activities increased 1.8-3.3 and 1.9-3.1 folds at 48 and 72 h, respectively, in the triple microbe treated challenged plants compared to unchallenged ones. Although, ascorbate peroxidase (APX) activity was significantly low, ascorbic acid (AA) and chitinase accumulation was high in the pathogen challenged plants. Antioxidant flavonols associated with host defence namely myricetin, quercetin and kaempferol also accumulated in high amounts in pathogen challenged plants. Among the microbial treatments, the triple microbe combination induced the highest response in all parameters as compared to dual or single application of the same microbes. The triple microbe consortium modulated the chickpea antioxidant mechanisms more efficiently and modulation of oxidative stress was directly correlated with lower plant mortality, thus demonstrating the synergistic behaviour of the microbes in protecting chickpea from the pathogen. © 2013 Association of Applied Biologists.
Thoracic epidural catheterization leading to delayed transient neurological symptoms with normal imaging findings
(2008) S.K. Mathur; A. Chakraborty; S. Jain; A. Jain
Paraparesis after epidural catheterization is rare but may be multifactorial. We report a case of temporary paraparesis in a 32-year-old female patient after thoracic epidural catheterization performed analgesia. A 16 G epidural needle was introduced at the T7-T8 interspace but as frank blood came through, it was withdrawn and was reinserted at the T8-T9 interspace. An 18 G epidural catheter was introduced and 10 ml of 0.125% bupivacaine with buprenorphine 150 mcg was given. Further top-ups were given for 48 h on complain of pain. There was an episode of hypotension after giving the epidural drug but later on the patient remained haemodynamically stable. On the fourth post-operative day, the patient reported paraparesis with heaviness and tingling sensation in both lower extremities. MRI was normal with no evidence of spinal cord compression, oedema, haematoma or abscess. The patient improved gradually within a period of 3 days. The possible causes of delayed onset of neurological symptoms are discussed. © 2008 The Authors.