Browsing by Author "A. Pal"

Now showing 1 - 8 of 8

Expanding neutrino oscillation parameter measurements in NOvA using a Bayesian approach
(American Physical Society, 2024) M.A. Acero; B. Acharya; P. Adamson; N. Anfimov; A. Antoshkin; E. Arrieta-Diaz; L. Asquith; A. Aurisano; A. Back; N. Balashov; P. Baldi; B.A. Bambah; A. Bat; K. Bays; R. Bernstein; T.J.C. Bezerra; V. Bhatnagar; D. Bhattarai; B. Bhuyan; J. Bian; A.C. Booth; R. Bowles; B. Brahma; C. Bromberg; N. Buchanan; A. Butkevich; S. Calvez; T.J. Carroll; E. Catano-Mur; J.P. Cesar; A. Chatla; S. Chaudhary; R. Chirco; B.C. Choudhary; A. Christensen; T.E. Coan; A. Cooleybeck; L. Cremonesi; G.S. Davies; P.F. Derwent; P. Ding; Z. Djurcic; M. Dolce; D. Doyle; D. Dueñas Tonguino; E.C. Dukes; A. Dye; R. Ehrlich; M. Elkins; E. Ewart; P. Filip; J. Franc; M.J. Frank; H.R. Gallagher; F. Gao; A. Giri; R.A. Gomes; M.C. Goodman; M. Groh; R. Group; A. Habig; F. Hakl; J. Hartnell; R. Hatcher; M. He; K. Heller; V. Hewes; A. Himmel; B. Jargowsky; J. Jarosz; F. Jediny; C. Johnson; M. Judah; I. Kakorin; D.M. Kaplan; A. Kalitkina; J. Kleykamp; O. Klimov; L.W. Koerner; L. Kolupaeva; R. Kralik; A. Kumar; C.D. Kuruppu; V. Kus; T. Lackey; K. Lang; P. Lasorak; J. Lesmeister; A. Lister; J. Liu; J.A. Lock; M. Lokajicek; M. Macmahon; S. Magill; W.A. Mann; M.T. Manoharan; M. Manrique Plata; M.L. Marshak; M. Martinez-Casales; V. Matveev; B. Mehta; M.D. Messier; H. Meyer; T. Miao; V. Mikola; W.H. Miller; S. Mishra; S.R. Mishra; R. Mohanta; A. Moren; A. Morozova; W. Mu; L. Mualem; M. Muether; K. Mulder; D. Myers; D. Naples; A. Nath; S. Nelleri; J.K. Nelson; R. Nichol; E. Niner; A. Norman; A. Norrick; T. Nosek; H. Oh; A. Olshevskiy; T. Olson; A. Pal; J. Paley; L. Panda; R.B. Patterson; G. Pawloski; O. Petrova; R. Petti; R.K. Plunkett; L.R. Prais; A. Rafique; V. Raj; M. Rajaoalisoa; B. Ramson; B. Rebel; P. Roy; O. Samoylov; M.C. Sanchez; S. Sánchez Falero; P. Shanahan; P. Sharma; A. Sheshukov; S. Shukla; D.K. Singha; W. Shorrock; I. Singh; P. Singh; V. Singh; E. Smith; J. Smolik; P. Snopok; N. Solomey; A. Sousa; K. Soustruznik; M. Strait; L. Suter; A. Sutton; K. Sutton; S. Swain; C. Sweeney; A. Sztuc; B. Tapia Oregui; P. Tas; T. Thakore; J. Thomas; E. Tiras; Y. Torun; J. Trokan-Tenorio; J. Urheim; P. Vahle; Z. Vallari; K.J. Vockerodt; T. Vrba; M. Wallbank; T.K. Warburton; M. Wetstein; D. Whittington; D.A. Wickremasinghe; T. Wieber; J. Wolcott; M. Wrobel; S. Wu; W. Wu; Y. Xiao; B. Yaeggy; A. Yankelevich; K. Yonehara; Y. Yu; S. Zadorozhnyy; J. Zalesak; R. Zwaska
NOvA is a long-baseline neutrino oscillation experiment that measures oscillations in charged-current νμ→νμ (disappearance) and νμ→νe (appearance) channels, and their antineutrino counterparts, using neutrinos of energies around 2 GeV over a distance of 810 km. In this work we reanalyze the dataset first examined in our previous paper [Phys. Rev. D 106, 032004 (2022)PRVDAQ2470-001010.1103/PhysRevD.106.032004] using an alternative statistical approach based on Bayesian Markov chain Monte Carlo. We measure oscillation parameters consistent with the previous results. We also extend our inferences to include the first NOvA measurements of the reactor mixing angle θ13, where we find 0.071≤sin22θ13≤0.107, and the Jarlskog invariant, where we observe no significant preference for the CP-conserving value J=0 over values favoring CP violation. We use these results to examine the effects of constraints from short-baseline measurements of θ13 using antineutrinos from nuclear reactors when making NOvA measurements of θ23. Our long-baseline measurement of θ13 is shown to be consistent with the reactor measurements, supporting the general applicability and robustness of the Pontecorvo-Maki-Nakagawa-Sakata framework for neutrino oscillations. © 2024 authors.
Joint neutrino oscillation analysis from the T2K and NOvA experiments
(Nature Research, 2025) Robert Miles Zwaska; Jaroslav Zalesak; S. Zadorozhnyy; Katsuya Yonehara; Alejandro Yankelevich; A. Yahaya; Barbara Yaeggy; Yiwen Xiao; Wanwei Wu; Shuai Wu; Jeremy A. Wolcott; Don Athula A. Wickremasinghe; D. W. Whittington; Matthew J. Wetstein; C. Weber; Thomas K. Warburton; Michael Wallbank; Abigail Victoria Waldron; K. J. Vockerodt; Z. Vallari; P. L. Vahle; Jon Urheim; J. Trokan-Tenorio; D. Tran; Yagmur Torun; M. Titus; Emrah Tiras; Jennifer A. Thomas; Tarak Thakore; P. Tas; N. Talukdar; Artur A. Sztuc; C. Sweeney; S. Swain; Andrew Sutton; Louise Suter; Matthew Strait; Karel Soustružník; Alexandre B. Sousa; Nickolas Solomey; Pavel V. Snopok; Jan Smolík; A. Smith; Dinesh Kumar Singha; Simranjit Singh Chhibra; Venktesh Singh; Prabhjot Singh; Ishwar Singh; Saurabh Shukla; W. Shorrock; Alexander K. Shmakov; Shivam; Andrey S. Sheshukov; P. Sharma; Peter Shanahan; S. Sánchez Falero; Mayly Calderón De La Barca Sánchez; O. B. Samoylov; P. K. Roy; Edgar E. Robles; Brian J. Rebel; Bryan J. Ramson; Miriama Rajaoalisoa; V. Raj; Aleena Rafique; L. R. Prais; J. C.C. Porter; Robert K. Plunkett; Roberto Petti; G. Pawloski; Ryan B. Patterson; Lipsarani Panda; Jonathan M. Paley; A. Pal; Mustafa Ozkaynak; T. Olson; Alexander G. Olshevskiy; H. Oh; A. Norrick; Andrew J. Norman; Evan Niner; Ryan J. Nichol; Jeffery K. Nelson; S. Nelleri; Donna L. Naples; D. Myers; Kevin Mulder; Mathew Muether; Leon Mualem; Wei Mu; A. D. Morozova; Adam Moren; Mohanta K. Rukmani; Sanjib Ratan Mishra; W. H. Miller; Ting Miao; Holger Meyer; M. D. Messier; Bhumika Mehta; Viktor A. Matveev
The landmark discovery that neutrinos have mass and can change type (or flavour) as they propagate—a process called neutrino oscillation1, 2, 3, 4, 5–6—has opened up a rich array of theoretical and experimental questions being actively pursued today. Neutrino oscillation remains the most powerful experimental tool for addressing many of these questions, including whether neutrinos violate charge-parity (CP) symmetry, which has possible connections to the unexplained preponderance of matter over antimatter in the Universe7, 8, 9, 10–11. Oscillation measurements also probe the mass-squared differences between the different neutrino mass states (Δm2), whether there are two light states and a heavier one (normal ordering) or vice versa (inverted ordering), and the structure of neutrino mass and flavour mixing12. Here we carry out the first joint analysis of datasets from NOvA13 and T2K14, the two currently operating long-baseline neutrino oscillation experiments (hundreds of kilometres of neutrino travel distance), taking advantage of our complementary experimental designs and setting new constraints on several neutrino sector parameters. This analysis provides new precision on the Δm322 mass difference, finding 2.43−0.03+0.04×10−3eV2 in the normal ordering and −2.48−0.04+0.03×10−3eV2 in the inverted ordering, as well as a 3σ interval on δCP of [−1.38π, 0.30π] in the normal ordering and [−0.92π, −0.04π] in the inverted ordering. The data show no strong preference for either mass ordering, but notably, if inverted ordering were assumed true within the three-flavour mixing model, then our results would provide evidence of CP symmetry violation in the lepton sector. © The Author(s) 2025.
Measurement of the νe -Nucleus Charged-Current Double-Differential Cross Section at «eν »=2.4 GeV Using NOvA
(American Physical Society, 2023) M.A. Acero; P. Adamson; L. Aliaga; N. Anfimov; A. Antoshkin; E. Arrieta-Diaz; L. Asquith; A. Aurisano; A. Back; M. Baird; N. Balashov; P. Baldi; B.A. Bambah; S. Bashar; K. Bays; R. Bernstein; V. Bhatnagar; D. Bhattarai; B. Bhuyan; J. Bian; A.C. Booth; R. Bowles; B. Brahma; C. Bromberg; N. Buchanan; A. Butkevich; S. Calvez; T.J. Carroll; E. Catano-Mur; S. Childress; A. Chatla; R. Chirco; B.C. Choudhary; A. Christensen; T.E. Coan; M. Colo; L. Cremonesi; G.S. Davies; P.F. Derwent; P. Ding; Z. Djurcic; M. Dolce; D. Doyle; D. Dueñas Tonguino; E.C. Dukes; R. Ehrlich; M. Elkins; E. Ewart; G.J. Feldman; P. Filip; J. Franc; M.J. Frank; H.R. Gallagher; R. Gandrajula; F. Gao; A. Giri; R.A. Gomes; M.C. Goodman; V. Grichine; M. Groh; R. Group; B. Guo; A. Habig; F. Hakl; A. Hall; J. Hartnell; R. Hatcher; H. Hausner; M. He; K. Heller; V. Hewes; A. Himmel; B. Jargowsky; J. Jarosz; F. Jediny; C. Johnson; M. Judah; I. Kakorin; D.M. Kaplan; A. Kalitkina; R. Keloth; O. Klimov; L.W. Koerner; L. Kolupaeva; S. Kotelnikov; R. Kralik; Ch. Kullenberg; M. Kubu; A. Kumar; C.D. Kuruppu; V. Kus; T. Lackey; K. Lang; P. Lasorak; J. Lesmeister; S. Lin; A. Lister; J. Liu; M. Lokajicek; J.M.C. Lopez; R. Mahji; S. Magill; M. Manrique Plata; W.A. Mann; M.T. Manoharan; M.L. Marshak; M. Martinez-Casales; V. Matveev; B. Mayes; M.D. Messier; H. Meyer; T. Miao; V. Mikola; W.H. Miller; S. Mishra; S.R. Mishra; A. Mislivec; R. Mohanta; A. Moren; A. Morozova; W. Mu; L. Mualem; M. Muether; K. Mulder; D. Naples; A. Nath; N. Nayak; S. Nelleri; J.K. Nelson; R. Nichol; E. Niner; A. Norman; A. Norrick; T. Nosek; H. Oh; A. Olshevskiy; T. Olson; J. Ott; A. Pal; J. Paley; L. Panda; R.B. Patterson; G. Pawloski; O. Petrova; R. Petti; D.D. Phan; R.K. Plunkett; A. Pobedimov; J.C.C. Porter; A. Rafique; L.R. Prais; V. Raj; M. Rajaoalisoa; B. Ramson; B. Rebel; P. Rojas; P. Roy; V. Ryabov; O. Samoylov; M.C. Sanchez; S. Sánchez Falero; P. Shanahan; S. Shukla; A. Sheshukov; I. Singh; P. Singh; V. Singh; E. Smith; J. Smolik; P. Snopok; N. Solomey; A. Sousa; K. Soustruznik; M. Strait; L. Suter; A. Sutton; S. Swain; C. Sweeney; A. Sztuc; R.L. Talaga; B. Tapia Oregui; P. Tas; B.N. Temizel; T. Thakore; R.B. Thayyullathil; J. Thomas; E. Tiras; J. Tripathi; J. Trokan-Tenorio; Y. Torun; J. Urheim; P. Vahle; Z. Vallari; J. Vasel; T. Vrba; M. Wallbank; T.K. Warburton; M. Wetstein; D. Whittington; D.A. Wickremasinghe; T. Wieber; J. Wolcott; W. Wu; Y. Xiao; B. Yaeggy; A. Yallappa Dombara; A. Yankelevich; K. Yonehara; S. Yu; Y. Yu; S. Zadorozhnyy; J. Zalesak; Y. Zhang; R. Zwaska
The inclusive electron neutrino charged-current cross section is measured in the NOvA near detector using 8.02×1020 protons-on-target in the NuMI beam. The sample of GeV electron neutrino interactions is the largest analyzed to date and is limited by ≃17% systematic rather than the ≃7.4% statistical uncertainties. The double-differential cross section in final-state electron energy and angle is presented for the first time, together with the single-differential dependence on Q2 (squared four-momentum transfer) and energy, in the range 1 GeV≤Eν<6 GeV. Detailed comparisons are made to the predictions of the GENIE, GiBUU, NEUT, and NuWro neutrino event generators. The data do not strongly favor a model over the others consistently across all three cross sections measured, though some models have especially good or poor agreement in the single differential cross section vs Q2. © 2023 authors. Published by the American Physical Society.
Membrane-damaging potential of natural L-(-)-usnic acid in Staphylococcus aureus
(2012) V.K. Gupta; S. Verma; S. Gupta; A. Singh; A. Pal; S.K. Srivastava; P.K. Srivastava; S.C. Singh; M.P. Darokar
The purpose of this investigation was to try to understand the antibacterial mechanism of L-(-)-usnic acid isolated for the first time from fruticose lichen Usnea subfloridana using clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentration (MIC) of L-(-)-usnic acid against the clinical isolates of MRSA and reference strain S. aureus MTCC-96 (SA-96) was in the range 25-50 μg/ml. Treatment of both reference and clinical strains (MRSA-ST 2071) with fourfold MIC concentrations (100-200 μg/ml) of L-(-)-usnic acid reduced the viability of cells without damaging the cell wall. However, the loss of 260 nm absorbing material and increase in propidium iodide uptake was observed in both of the strains. Similarly, a combined effect of L-(-)-usnic acid (25-50 μg/ml) and 7.5% NaCl resulted in a reduced number of viable cells within 24 h in comparison to the control. These observations clearly indicate that L-(-)-usnic acid exerts its action by disruption of the bacterial membrane. Further, in vivo efficacy showed that L-(-)-usnic acid significantly (p<0.001) lowered the microbial load of spleen at doses ranging from 1 to 5 mg/kg. Further, toxicity studies in infected mice at doses 20 times higher than the efficacious dose indicated L-(-)usnic acid to be safe. Paradoxically, L- (-)usnic acid exhibited changes in serum triglycerides, alkaline phosphatase (ALKP) and liver organ weight in the healthy mice administered with only 25 mg/kg body weight. The results obtained in this study showed that natural L-(-)- usnic acid exerts its antibacterial activity against MRSA by disruption of the cell membrane. Further, the natural L-(-)- usnic acid was found to be safe up to 100 mg/kg body weight, thereby, making it a probable candidate for treating S. aureus infections. © 2012 Springer-Verlag.
Search for CP -Violating Neutrino Nonstandard Interactions with the NOvA Experiment
(American Physical Society, 2024) M.A. Acero; B. Acharya; P. Adamson; L. Aliaga; N. Anfimov; A. Antoshkin; E. Arrieta-Diaz; L. Asquith; A. Aurisano; A. Back; N. Balashov; P. Baldi; B.A. Bambah; A. Bat; K. Bays; R. Bernstein; T.J.C. Bezerra; V. Bhatnagar; D. Bhattarai; B. Bhuyan; J. Bian; A.C. Booth; R. Bowles; B. Brahma; C. Bromberg; N. Buchanan; A. Butkevich; S. Calvez; T.J. Carroll; E. Catano-Mur; J.P. Cesar; A. Chatla; S. Chaudhary; R. Chirco; B.C. Choudhary; A. Christensen; M.F. Cicala; T.E. Coan; A. Cooleybeck; C. Cortes-Parra; D. Coveyou; L. Cremonesi; G.S. Davies; P.F. Derwent; Z. Djurcic; M. Dolce; D. Doyle; D. Dueñas Tonguino; E.C. Dukes; A. Dye; R. Ehrlich; E. Ewart; P. Filip; J. Franc; M.J. Frank; H.R. Gallagher; F. Gao; A. Giri; R.A. Gomes; M.C. Goodman; M. Groh; R. Group; A. Habig; F. Hakl; J. Hartnell; R. Hatcher; M. He; K. Heller; V. Hewes; A. Himmel; Y. Ivaneev; A. Ivanova; B. Jargowsky; J. Jarosz; C. Johnson; M. Judah; I. Kakorin; D.M. Kaplan; A. Kalitkina; J. Kleykamp; O. Klimov; L.W. Koerner; L. Kolupaeva; R. Kralik; C.D. Kuruppu; V. Kus; T. Lackey; K. Lang; J. Lesmeister; A. Lister; J. Liu; J.A. Lock; M. Lokajicek; M. Macmahon; S. Magill; W.A. Mann; M.T. Manoharan; M. Manrique Plata; M.L. Marshak; M. Martinez-Casales; V. Matveev; B. Mehta; M.D. Messier; H. Meyer; T. Miao; V. Mikola; W.H. Miller; S. Mishra; S.R. Mishra; A. Mislivec; R. Mohanta; A. Moren; A. Morozova; W. Mu; L. Mualem; M. Muether; K. Mulder; D. Myers; D. Naples; A. Nath; S. Nelleri; J.K. Nelson; R. Nichol; E. Niner; A. Norman; A. Norrick; T. Nosek; H. Oh; A. Olshevskiy; T. Olson; M. Ozkaynak; A. Pal; J. Paley; L. Panda; R.B. Patterson; G. Pawloski; O. Petrova; R. Petti; L.R. Prais; A. Rafique; V. Raj; M. Rajaoalisoa; B. Ramson; M. Ravelhofer; B. Rebel; P. Roy; O. Samoylov; M.C. Sanchez; S. Sánchez Falero; P. Shanahan; P. Sharma; A. Shmakov; A. Sheshukov; S. Shukla; D.K. Singha; W. Shorrock; I. Singh; P. Singh; V. Singh; E. Smith; J. Smolik; P. Snopok; N. Solomey; A. Sousa; K. Soustruznik; M. Strait; L. Suter; A. Sutton; K. Sutton; S. Swain; C. Sweeney; A. Sztuc; B. Tapia Oregui; P. Tas; T. Thakore; J. Thomas; E. Tiras; Y. Torun; J. Tripathi; J. Trokan-Tenorio; J. Urheim; P. Vahle; Z. Vallari; J. Vasel; J.D. Villamil; K.J. Vockerodt; T. Vrba; M. Wallbank; M. Wetstein; D. Whittington; D.A. Wickremasinghe; T. Wieber; J. Wolcott; M. Wrobel; S. Wu; W. Wu; Y. Xiao; B. Yaeggy; A. Yahaya; A. Yankelevich; K. Yonehara; Y. Yu; S. Zadorozhnyy; J. Zalesak; R. Zwaska
This Letter reports a search for charge-parity (CP) symmetry violating nonstandard interactions (NSI) of neutrinos with matter using the NOvA Experiment, and examines their effects on the determination of the standard oscillation parameters. Data from νμ(ν¯μ)→νμ(ν¯μ) and νμ(ν¯μ)→νe(ν¯e) oscillation channels are used to measure the effect of the NSI parameters Iµeμ and Iµeτ. With 90% CL the magnitudes of the NSI couplings are constrained to be |Iµeμ| 0.3 and |Iµeτ| 0.4. A degeneracy at |Iµeτ|≈1.8 is reported, and we observe that the presence of NSI limits sensitivity to the standard CP phase δCP. © 2024 authors.
Sensitivity of β4 values extracted from quasi elastic barrier distribution to the 2n transfer channel
(Springer, 2023) G. Mohanto; A. Parihari; Y.K. Gupta; A. Pal; A. Gandhi; Sukanya De; K. Ramachandran; E.T. Mirgule; B. Srinivasan; K. Kalita; A. Kumar; N.K. Deb; K. Rani; A. Tejaswi; C. Vadagama; Vishal Bharud; L.S. Danu; B.J. Roy; M. Kushwaha; B.K. Nayak; A. Saxena
In recent times, the Fusion Barrier Distributions (FBD) determined from quasi-elastic scattering measurements have been employed to determine the hexadecapole deformation parameter β4 value precisely. In reactions where transfer channels are favourable, coupling due to transfer may affect the determination of β4 . In order to study the role of transfer channels while determining β4 from barrier distribution, the quasi-elastic scattering measurements have been carried out in 16 O + 176 Yb. Quasi-elastic scattering excitation function has been measured at backward angles with respect to the beam direction and barrier distribution Dqel(E) has been derived. Experimentally obtained barrier distribution has been compared with coupled channel calculations using CCFULL code. The effect of two neutron transfer and hexadecapole deformation has been studied using coupled channel calculation. χ2 was calculated in a two dimensional space of β4 and neutron transfer strength Ptr . Without considering neutron transfer, χ2 minimization of Dqel(E) was not possible and the best-fit was found over a small range of β4 and Ptr . At Ptr= 0.37 , corresponding to minimum χ2 , the β4 of 176 Yb is determined to be 0.00 ± 0.015 . This value of β4 is in agreement with that obtained from Coulomb excitation measurement. © 2023, The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature.
Study of the surrogate ratio method by determination of 56Fe(n,xp) cross sections
(Elsevier B.V., 2024) Aman Sharma; Punit Dubey; Utkarsha Mishra; Nitin Dubey; Jyoti Pandey; Ramandeep Gandhi; A. Pal; Abhijit Baishya; T. Santhosh; P.C. Rout; B.K. Nayak; S. Santra; A. Chakraborty; A. Kumar
In recent years (n,xp) cross sections of some long-lived radionuclei which are of importance in the upcoming fusion reactor technologies have been constrained using the surrogate ratio method. But the (n,xp) cross sections for the stable nuclei for which a great wealth of data is available from the direct measurements have not been constrained using surrogate ratio method yet, so that the consistency of the surrogate ratio method can be checked. In this study we have investigated the validity of surrogate ratio method by constraining 56Fe(n,xp) cross sections and then the results are compared with the available experimental data, evaluated data and the statistical model predictions. In this study 52Cr(n,xp) reaction has been used as the reference reaction in the surrogate ratio method. It is found in this study that (n,xp) cross sections constrained using surrogate ratio method are sensitive to the spin distribution of the compound nuclei populated in the surrogate reactions. It is also presented in this study that the proton emission probabilities for 57Fe and 53Cr are highly spin dependent. It is concluded that the surrogate ratio method is not suitable for constraining the (n,xp) cross sections. © 2023 The Authors
Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection
(Oxford University Press, 2023) A. Mukherjee; G. Kumar; A. Turuk; A. Bhalla; T.C. Bingi; P. Bhardwaj; T.D. Baruah; S. Mukherjee; A. Talukdar; Y. Ray; M. John; J.R. Khambholja; A.H. Patel; S. Bhuniya; R. Joshi; G.R. Menon; D. Sahu; V.V. Rao; B. Bhargava; S. Panda; P. Mishra; Y. Panchal; L.K. Sharma; A. Agarwal; G.D. Puri; V. Suri; K. Singla; R. Mesipogu; V.S. Aedula; M.A. Mohiuddin; D. Kumar; S. Saurabh; S. Misra; P.K. Kannauje; A. Kumar; A. Shukla; A. Pal; S. Chakraborty; M. Dutta; T. Mondal; S. Chakravorty; B. Bhattacharjee; S.R. Paul; D. Majumder; S. Chatterjee; A. Abraham; D. Varghese; M. Thomas; N. Shah; M. Patel; S. Madan; A. Desai; M.L. Kala Yadhav; R. Madhumathi; G.S. Chetna; U.K. Ojha; R.R. Jha; A. Kumar; A. Pathak; A. Sharma; M. Purohit; L. Sarangi; M. Rath; A.D. Shah; L. Kumar; P. Patel; N. Dulhani; S. Dube; J. Shrivastava; A. Mittal; L. Patnaik; J.P. Sahoo; S. Sharma; V.K. Katyal; A. Katyal; N. Yadav; R. Upadhyay; S. Srivastava; A. Srivastava; N.N. Suthar; N.M. Shah; K. Rajvansh; H. Purohit; P.R. Mohapatra; M.K. Panigrahi; S. Saigal; A. Khurana; M. Panchal; M. Anderpa; D. Patel; V. Salgar; S. Algur; R. Choudhury; M. Rao; D. Nithya; B.K. Gupta; B. Kumar; J. Gupta; S. Bhandari; A. Agrawal; M. Shameem; N. Fatima; S. Pala; V. Nongpiur; S. Chatterji; S. Mukherjee; S.K. Shivnitwar; S. Tripathy; P. Lokhande; H. Dandu; A. Gupta; V. Kumar; N. Sharma; R. Vohra; A. Paliwal; M. Pavan Kumar; A. Bikshapathi Rao; N. Kikon; R. Kikon; K. Manohar; Y. Sathyanarayana Raju; A. Madharia; J. Chakravarty; M. Chaubey; R.K. Bandaru; M. Ali Mirza; S. Kataria; P. Sharma; S. Ghosh; A. Hazra
Objectives: This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). Methods: NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined. Results: Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6–7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4–0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3–0.7)] were protected from in-hospital mortality. Conclusions: WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality. © The Author(s) 2022.