Browsing by Author "A. Trigunayat"

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A Pilot Study on Knowledge and Experience on use of Generic Medicines among Healthcare Professionals
(Research Journal of Pharmacy and Technology, 2022) Vinay Kumar Gupta; Amit Singh; Ajay K. Gupta; A. Trigunayat; B. Kumar
Those medicines which are having same efficacy as that of their branded and expensive counterparts are known as Generic medicines. Compare to branded medicines, generic medicines have similar route of administration, indication, side effects, strength. Contrary to lower price and affordability the generic medicines are not so popular among healthcare professionals. The objective of this study is to analyse, knowledge and experience on use of generic medicines among healthcare professionals. A pilot study was conducted at Institute of Medical Sciences (IMS) Banaras Hindu University Varanasi India. This was a questionnaire-based cross-sectional study. The participants were doctors, nurses, pharmacists and others (research scholars and PG students). Chi square test used to find out p value. The overall response rate was 84.61 percent (55/65). Among all participants 12.7 percent did not “heard about Pradhan Mantri Jan Aushadhi Pariyojana Kendra”. Among all participants only 40 percent were not aware about Pradhan Mantri Jan Aushadhi Pariyojana Kendra situated in their area. Among all participants 72.73% aware about safe generic medicines, while among participant groups 60% of participating doctors, all nursing and pharmacy professionals and 72% of others accepted that generic medicines are safe as like branded medicines. A variation observed in respect of knowledge, and experience on generic medicines among participants. 40% (percent) of participating doctors did not believe in generic medicines and opted that the generic medicines are not safe as like branded medicines. Therefore, need for more training/awareness programmes on generic medicine arises. Need for building trust among healthcare professionals on generic medicines required. © RJPT All right reserved.
Physico-chemical characterization and in-vivo evaluation of Jasad Bhasma: An Indian traditional biomedicine
(2012) S.K. Singh; A.K. Singh; D.N.S. Gautam; A. Trigunayat; M. Kumar; S.B. Rai
Indian traditional system of medicine Ayurveda makes use of herb and metal based preparations called Bhasma (literal meaning ash) which are prepared by several processing steps including repeated calcinations of the metal in the presence of herbal constituents (juices, decoctions, powders, etc). These medicines are very effective; however, standardization of such medicines as to their preparation, composition, structure, toxicity, and mechanism of action, etc is a challenging but necessary task. Present work on Zinc based Jasad Bhasma is an attempt to unravel the science behind such preparations and also to establish a general parameter to standardize them. Jasad Bhasma has been prepared using strict protocol listed in Ayurveda texts. Further, the final prepared medicine and the material in intermediate steps of the processing of the medicine both have been characterized. In-vivo evaluation of the drug has also been carried out. Our analysis suggests that different stages of the processing of the medicine convert the metallic Zn into ZnO with reduction in particle size in sub-micrometer range. A small fraction of the particles also lies in nano regime (<100 nm). In addition, presence of biocompatible material (like silica and carbon compound) and nutrient elements is also observed in the medicine due to natural precursors used during the preparation of the medicine. The medicine has been found safe under the recommended dosages.