Browsing by Author "Ajay Kumar Meena"

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Biopolymers in batteries: concepts and applications
(Elsevier, 2025) Rudramani Tiwari; Km Parwati; Rajshree N. Rai; Pushpesh Ranjan; Krishna Karthik Kumar; Ajay Kumar Meena; S. Krishnamoorthi; Archana K. Singh
Energy storage devices play a pivotal role in managing energy consumption across various sectors such as automotive and electronics. These devices, such as supercapacitors and batteries, largely depend on the materials used in their construction to determine their efficiency and lifespan. Although synthetic materials have traditionally been used, they possess inherent drawbacks due to their synthetic nature and environmental impact throughout their lifecycle, from production to disposal. Biopolymer materials offer a promising alternative, leveraging their natural abundance to address environmental concerns associated with synthetic counterparts. These materials have inherent biodegradability, renewability, and low environmental impact. One of the significant advantages of biopolymers is their biodegradability. These materials offer a wide range of properties and can be tailored to specific applications through chemical modification and processing techniques. This chapter explores concepts and applications of biopolymer-based devices as a solution to mitigate future environmental challenges posed by energy storage technologies. © 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
In Silico Rho Kinase Inhibition and FP-Agonist Potential Study of Rotenoids Present in Boerhavia diffusa Root for Curing Uveitic Glaucoma
(John Wiley and Sons Inc, 2025) Ajay Kumar Meena; Rudramani Tiwari; Gnanabhaskar Danaboina; Kundan Kumar Ojha; Arundhati Mehta; Jagriti Kamra; Ashwini Kumar Dixit; Arjun Singh
The acute pathogenesis with rapid inflammation enhances the intertrabecular spaces which refers to an increase in intraocular pressure (IOP) in uveitic glaucoma. Boerhaavia diffusa (B. diffusa) plant root contains boeravinone A–J, a class of rotenoids exhibiting hepatoprotective, immunomodulatory, and anti-inflammatory actions. This article reports a comparative in silico Rho-kinase inhibition and FP-agonists study of these rotenoids. ADMET study reflects the suitability of rotenoids in terms of drug-likeness, human intestinal absorption, mitochondrial subcellular localization, and class-III toxicological compounds for real application as drug molecules. Docking study for Rho-kinase inhibition potential with 3tku-protein shows binding energies between −6.101 and −4.129 kcal/mol with an inhibition constant of 0.05–2.54 mM for boeravinone A–J against standard fasudil (−4.285 kcal/mol) molecule which has inhibition constant of 0.015 mM. Docking study for FP-agonist potential with 2f38-protein shows binding energies between −9.647 and −5.602 kcal/mol for boeravinone A–J with inhibition constants of 0.01–0.09 mM, against standard bimatoprost (−9.603 kcal/mol) and latanoprost (−10.096 kcal/mol) molecule. This MD simulation results an equilibrized dynamic behavior and stability of 3tku-boeravinone-E and 2f38-boeravinone-E complexes, under reference standards conditions. This study suggests that these rotenoids can be useful as a curative agent in uveitic glaucoma as an anti-inflammatory agent and IOP reducer. © 2025 Wiley-VCH GmbH.