Browsing by Author "Ajit Kumar Gupta"

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Lighting the Path: A Sustainable Catalyst Free Approach Toward Trifluoromethylation of Indoles
(John Wiley and Sons Inc, 2025) Nikita Gupta; Imtiaz Ahmed; Ajit Kumar Gupta; Kalpajyoti Dihingia; Biswajit Maiti; Vijay Kumar Das
In this study, we report an innovative development of a visible light-induced synthesis of trifluoromethyl indoles. This novel methodology not only obviates the need for traditional catalysts but also harnesses the energy of photons to selectively introduce trifluoromethyl groups into indole substrates. Leveraging the inexpensive, easily handled, and non-toxic Langlois reagent (CF3SO2Na) as the CF3 source, in conjunction with visible light and tert-butyl hydrogen peroxide (TBHP), facilitates the direct C─H trifluoromethylation of indoles. The mechanistic pathway of the reaction is predicted with the help of density functional theory (DFT) calculations at the (U)B3LYP/6–31++G(d,p)/SMD/acetonitrile level of theory. © 2025 Wiley-VCH GmbH.
Photochemically Induced Approaches to the Syntheses of β-Lactams
(John Wiley and Sons Inc, 2024) Imtiaz Ahmed; Nikita Gupta; Ajit Kumar Gupta; Vijay Kumar Das
The synthesis of β-lactam scaffolds is of paramount importance due to their extensive applications in pharmaceuticals, particularly as antibiotics. Visible light photocatalysis has emerged as a revolutionary approach in this domain, providing a sustainable and efficient pathway for β-lactam construction. In this review, we meticulously discuss the recent developments in the synthesis of photocatalysed β-lactam frameworks. A key focus is the Staudinger reaction, traditionally a cornerstone in β-lactam synthesis, and its adaptation to visible light photocatalysis. We explore the mechanistic intricacies of the Staudinger reaction under photochemical conditions, along with other pivotal cyclization strategies enabled by visible light. By illuminating the novel photocatalytic routes to β-lactams, this review provides a thorough understanding of the state-of-the-art techniques and sets the stage for future innovations in the green synthesis of these critical compounds. © 2024 Wiley-VCH GmbH.