Browsing by Author "Ajit Kumar Kumar Singh"

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Oxidase-Like Nanozyme Activity of Ultrathin Copper Metal–Organic Framework Nanosheets With High Specificity for Catechol Oxidation
(John Wiley and Sons Inc, 2025) Ajit Kumar Kumar Singh; D. R. Sharma; Devesh Kumar Singh; Sonu Sarraf; Aviru Kumar Basu; Vellaichamy Ganesan; Avishek Saha; Arindam Indra
In nature, catechol oxidase catalyzes the oxidation of o-diphenol to o-quinone to produce a series of highly important polyphenolic natural products. Although mimicking the functionality of natural enzyme using a nanozyme was found to be beneficial, attaining a high specificity is challenging. Herein, we have explored the thickness-dependent oxidase activity and specificity of Cu-metal-organic framework (MOF) nanosheets. The unique synthetic method offers control over the thickness of the Cu-MOF nanosheets. The ultrathin (4 nm) Cu-MOF (Cu-UMOF) nanosheets as an oxidase nanozyme exhibit high specificity for catechol oxidation without having any peroxidase activity. Interestingly, the thicker (20–30 nm) Cu-MOF nanosheets showed poor catechol oxidase and peroxidase activity. The binuclear Cu-center, coordinative, and electronic unsaturation tuned electronic structure in Cu-UMOF, resulting in higher specificity for catechol oxidation than thicker Cu-MOF. © 2024 Wiley-VCH GmbH.