Browsing by Author "Akanksha Malaiya"

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An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations
(Elsevier Ireland Ltd, 2022) Shiv Kumar Prajapati; Akanksha Malaiya; Gaurav Mishra; Dolly Jain; Payal Kesharwani; Nishi Mody; Amirhossein Ahmadi; Rishi Paliwal; Ankit Jain
Ethnopharmacological relevance: The coronavirus disease (COVID-19) has relentlessly spread all over the world even after the advent of vaccines. It demands management, treatment, and prevention as well with utmost safety and effectiveness. It is well researched that herbal medicines or natural products have shown promising outcomes to strengthen immunity with antiviral potential against SARS-COV-2. Aim of the review: Our objective is to provide a comprehensive insight into the preventive and therapeutic effects of herbal medicines and products (Ayurvedic) for pre-and post-COVID manifestations. Material and method: The database used in the text is collected and compiled from Scopus, PubMed, Nature, Elsevier, Web of Science, bioRxiv, medRxiv, American Chemical Society, and clinicaltrials.gov up to January 2022. Articles from non-academic sources such as websites and news were also retrieved. Exploration of the studies was executed to recognize supplementary publications of research studies and systematic reviews. The keywords, such as “SARS-COV-2, coronavirus, COVID-19, herbal drugs, immunity, herbal immunomodulators, infection, herbal antiviral drugs, and WHO recommendation” were thoroughly searched. Chemical structures were drawn using the software Chemdraw Professional 15.0.0.160 (PerkinElmer Informatics, Inc.). Result: A plethora of literature supports that the use of herbal regimens not only strengthen immunity but can also treat SARS-COV-2 infection with minimal side effects. This review summarizes the mechanistic insights into herbal therapy engaging interferons and antibodies to boost the response against SARS-COV-2 infection, several clinical trials, and in silico studies (computational approaches) on selected natural products including, Ashwagandha, Guduchi, Yashtimadhu, Tulsi, etc. as preventive and therapeutic measures against COVID. We have also emphasized the exploitation of herbal medicine-based pharmaceutical products along with perspectives for unseen upcoming alike diseases. Conclusion: According to the current state of art and cutting-edge research on herbal medicines have showed a significant promise as modern COVID tools. Since vaccination cannot be purported as a long-term cure for viral infections, herbal/natural medicines can only be considered a viable alternative to current remedies, as conceived from our collected data to unroot recurring viral infections. © 2022 Elsevier B.V.
Antimicrobial Application Potential of Phytoconstituents from Turmeric and Garlic
(Springer Science and Business Media Deutschland GmbH, 2021) Shiv Kumar Prajapati; Gaurav Mishra; Akanksha Malaiya; Ankit Jain; Nishi Mody; Ashok M. Raichur
In recent years, natural phytochemicals are gaining much attention for their antimicrobial potential. Garlic and turmeric are most widely used from the natural source, and their constituents directly or indirectly provide various health benefits, especially due to antimicrobial potential. Though the conventional antimicrobial compounds are effective against various pathogens, up till now there is a necessity of effective agents against MDR pathogens. Phytochemicals have been used for their antimicrobial potential from ancient times. These phytochemicals can work by multiple mechanisms, such as by inhibiting target modifying and drug degrading enzymes or as efflux pump inhibitors. The use of natural phytoconstituents (e.g., curcumin from turmeric and allicin from garlic) from these two medicinal plants may be an alternative strategy and can overcome the side effects associated with antibiotics or other allopathic means of treatment. A wide range of indications has revealed the therapeutic efficacy of these compounds on bacterial, viral, and fungal infections. To improve safety and efficacy, these phytoconstituents have been delivered using nanoformulations such as liposomes, hydrogels, and nanoparticles for the treatment against different bacteria, viruses, fungi, and parasites infections. This chapter is attempted to discuss phytochemistry, antimicrobial mechanisms, and application potential of phytoconstituents from turmeric and garlic. © 2020, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Application of Coatings with Smart Functions
(Bentham Science Publishers, 2021) Shiv K. Prajapati; Gaurav Mishra; Akanksha Malaiya; Payal Kesharwani; Nishi Mody; Ankit Jain
To obtain the different types of technical utilities, the surface of various systems needs to be modified by altering surface properties using polymer coating(s) which is one of the emerging technologies to impart smart functions. The polymer coating has a wide application in various fields such as biomedicals, pharmaceuticals, packaging, corrosion control, electronics, and abrasion control. The coating can be done using both biodegradable and non-degradable polymers having eminent properties such as better mechanical strength, anti-wear characteristics, corrosion protection, electrical conductivity, biocompatibility, and high surface functionality. Several methods have been reported for the fabrication of defensive coatings. A thoughtful selection of polymers, coating methods, and critical process parameters may bring forth a better protective coating with advanced properties. This review discusses the objectives of the polymer coating, various coating technologies, and their smart applications. © 2021 Bentham Science Publishers.