Browsing by Author "Akher Ali"

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Mechanical and biological response of (CeO2+La2O3)-substituted 45S5 bioactive glasses for biomedical application
(Springer, 2020) Md Ershad; Akher Ali; Niraj Singh Mehta; Rajesh Kumar Singh; Santosh Kumar Singh; Ram Pyare
In the present study, bioactive glasses of specific compositional formula (45-X) SiO2, 24.5 Na2O, 24.5 CaO, and 6 P2O5 (wt%) were made by substitute of X = (0.0, 0.5, 1.0, 1.5, and 2.0) equal wt% of CeO2 and La2O3. The mixed homogeneous glass powder melted in a platinum crucible at the furnace temperature of 1400 ± 5 °C with air as a furnace environment. Synthesized novel Bioglass® was further characterized for in vitro bioactivity and physicomechanical properties. Microstructures of developed glass samples were evaluated by SEM. Bioactivity of glass samples was assessed in simulated body fluid (SBF) for different time intervals and it was evaluated using XRD, FTIR, and SEM. Furthermore, the substitution of CeO2 and La2O3 in the base glass enhances its cytocompatibility and cell supportive properties. Also, microhardness and flexural strength of base Bioglass® was enhanced with the incorporation of CeO2 and La2O3 and resulted in increasing density of doped glass. Thus, the developed CeO2 and La2O3-incorporated bioactive glasses with superior mechanical properties have higher density and superior mechanical properties which make these bioactive glasses a suitable candidate for bone implant application. © 2020, Australian Ceramic Society.
Studies on effect of CuO addition on mechanical properties and in vitro cytocompatibility in 1393 bioactive glass scaffold
(Elsevier Ltd, 2018) Akher Ali; Md Ershad; Vikash Kumar Vyas; Sumit Kumar Hira; Partha Pratim Manna; B.N. Singh; Shushma Yadav; P. Srivastava; S.P. Singh; Ram Pyare
Copper doped bioactive glasses have been reported as the potential biomaterial for diseased or damaged bone repair and act as stimulants to new bones formation. In the present manuscript, we have synthesized 1393 derived glass based scaffold with the general formula of (54.6 − X)SiO2·6Na2O·7.9 K2O·7.7 MgO·22 CaO·1.74 P2O5·XCuO (all are in mole%; where X = 0,1,2,3) through traditional melt-quench route and the samples were designated as 1393, 1393-1Cu, 1393-2Cu and 1393-3Cu respectively. Polymer foam with interconnected pores has been used on later stage to prepare porous (porosity > 50%) bioactive scaffolds. The addition of CuO in glass scaffolds was to ensure its cytocompatibility, ability to enhance cell proliferation and improvements in mechanical properties. Increasing trend of CuO in the 1393 glass scaffold has resulted in increasing compressive and flexural strength and elastic modulus of the scaffolds. In-vitro cellular growth inhibition and cell viability assay of CuO incorporated 1393 glass scaffolds demonstrated that it did not inhibit proliferation and viability of human squamous carcinoma cell (SCC-25) at low materials concentration. The materials caused moderate level of apoptosis at higher concentrations and were also tolerated by human RBC as studied by hemolytic assay. The results indicated that CuO incorporated 1393 scaffolds could be a potential biomaterial for neobone tissue engineering application. © 2018 Elsevier B.V.