Browsing by Author "Akshat Pandey"

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Case Report: Rhino-orbital Mucormycosis Related to COVID-19: A Case Series Exploring Risk Factors
(American Society of Tropical Medicine and Hygiene, 2022) Sushil Kumar Aggarwal; Upinder Kaur; Dolly Talda; Akshat Pandey; Sumit Jaiswal; Ahalya Kanakan; Anshuman Singh; Sankha Shubhra Chakrabarti
There has been a surge of rhino-orbital mucormycosis cases in India in the wake of the second wave of the COVID-19 pandemic. It has been widely suggested that dysglycemia resulting from diabetes which is a common comorbidity in COVID-19 patients, and indiscriminate steroid use has resulted in this surge. We report a series of 13 cases of rhino-orbital mucormycosis in COVID-19 patients admitted to our center between mid-April and early June 2021. The cases showed a male preponderance, two patients had loss of vision, and four of them showed intracranial extension of disease. Twelve patients had received steroids and 12 had preexisting or newly diagnosed diabetes, both steroid use and diabetes being the most common identified risk factors. Considering other possible risk factors, immunosuppressed state, antiviral or ayurvedic (Indian traditional) medications, and oxygen therapy were not associated with a definite risk of mucormycosis, because they were not present uniformly in the patients. We propose that COVID-19 itself, through molecular mechanisms, predisposes to mucormycosis, with other factors such as dysglycemia or steroid use increasing the risk. © 2022 American Society of Tropical Medicine and Hygiene. All rights reserved.
To Study the Incidence of Biofilm Formation, its Microbiology and its Effect on the Development of Acute and Chronic Rhinosinusitis- A Prospective Study
(Springer, 2025) Akshat Pandey; Ramraj Yadav; Vivek Mishra; Akanksha Sharma; Sanjay Kumar Saroj; Rahul Yadav; Jeffrey Oswin Rynjah; Srishti Bhansali; Anjalika Sharma; Gundra Chandra Shekar; Sishupal Yadav; Arpit Goyal; Ragini Tilak; Sushil Kumar Aggarwal
Bacterial biofilms are organised complex structures having polymicrobial nature in a single community, which provide protection to bacteria from antibiotics by various means. The aim of our study was to determine the prevalence of biofilm-forming bacteria in clinical isolates of acute and chronic rhinosinusitis (ARS and CRS) patients with sinonasal mucopurulence. To know the incidence of bacterial biofilms in patient with ARS and CRS, to study the microbiology of bacterial biofilms in ARS and CRS, to assess the role and effects of biofilm in ARS and CRS and to correlate the association between the formation of the biofilm and development of rhinosinusitis. This prospective study was carried out at a tertiary care centre in Eastern part of India, in which 60 patients were taken as sample size. All patients of rhinosinusitis between age-group of 10 to70 years, who came to our out-patient department, were taken for our study. Biofilm formation was observed in 50% cases and were absent in 50% cases of chronic rhinosinusitis in our study. 83.3% (50) of patients out of 60 patients got improved after treatment and recurrence was observed in only 16.6% (10) of patients. Recurrence was more at 3 months follow-up as compared to follow-up at 1 month, though it was not statistically significant. Though our study highlighted the incidence and role of biofilms in the development of chronic rhinosinusitis, but few more randomized controlled studies involving larger sample sizes should be done to exactly determine the pathophysiological role of biofilms in the development and recurrence of acute and chronic rhinosinusuitis. © Association of Otolaryngologists of India 2024.