Browsing by Author "Ambrish Kumar Singh"

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A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer
(Springer, 2024) Naiyer Shahzad; Ibrahim Abdel Aziz Ibrahim; Abdullah R. Alzahrani; Saeed S. Al-Ghamdi; Ibrahim Mufadhi M. Alanazi; Md. Parwez Ahmad; Ambrish Kumar Singh; Mohammed Ayad Alruqi; Imran Shahid; Asif Equbal; Mohd Fahami Nur Azlina
Gastric ulcers are the most common chronic gastrointestinal tract disorders, marked by an inflamed break of the mucus membrane covering the alimentary tract. According to recent research, stress-induced ulcers are widespread in our society. A stress ulcer is a mucosal defect that may become complicated due to upper gastrointestinal tract bleeding. The underlying cause of this condition is pH. Physiological stress leads to severe sickness by triggering the excessive secretion of peptic juices or gastric acid. There is a never-ending quest for safe and affordable medication for this disorder. Nature offers many medicinal plants that can be used to treat a wide range of human ailments. Due to their relatively harmless and comparatively free of harmful effects, health-promoting features, pharmacological practices, and affordability to common people to regulate various diseases, medicinal plants, and herbal preparations are gaining a lot of interest in scientific communities these days. Many studies have recently been performed to classify extracts and their constituents that may have a therapeutic effect on peptic ulcers. Therefore, this review aims to address the molecular mechanisms and pharmacological effects of various phytochemicals related to stress-induced gastric ulcers. Combining phytochemical constituents with modern drugs and treatment methods can lead to the development of therapeutic drugs for gastric ulcers. Gastric ulcers and other related diseases may be treated permanently with this approach. © The Author(s) 2024.
Ayurvedic strategy to achieve sustainable development goal 3: Management of cancer (Arbuda)
(Nova Science Publishers, Inc., 2022) Anupriya Singh; Anjali Upadhyay; Jyoti Singh; Ambrish Kumar Singh; Dev Nath Singh Gautam; Narendra Kumar Singh
Cancer is the second leading cause of morbidity and mortality as well as growing health problems worldwide. Effective drugs and therapies are available for different kinds of cancer also having side effects; hence people seek relatively safer as well as cost-effective alternative and complementary medicines for the treatment of cancer. The objective of the present chapter is to provide Ayurvedic concept-based evidence for the treatment and management of cancer to the academician and researcher who garners interest in cancer. The present study provides comprehensive information about Arbuda (cancer) and its probable remedy through Ayurveda and fulfilling the Sustainable Development Goals (SDGs) that is SDG 3. Arbuda develops due to Mithya Ahar (unhealthy diet) and Mithya Vihar (unhealthy lifestyle) leading to imbalance in Vatadi Doshas (regulatory functional factors of the body) which leads to vitiation of Dhatus (major structural components of the body). Vitiated Dhatus results in the formation of muscular swelling anywhere in the body with the appearance of large, circular, immobile, less painful, slowly growing and deep-seated swelling such a clinical entity termed as Arbuda. Symptomatically, Arbuda may have a resemblance with clinical entities such as cancer. However, the exact pathogenesis of cancer does not match these two conditions, but still, it may be possibly correlated up to a certain extent. The involvement of one or two Doshas (Vata, Pitta and Kapha), produce benign neoplasm which is harmless but the association of all three Doshas (Sannipataja/Tridoshaja) produces malignant neoplasm, which is harmful. The term Dviarbuda (metastasis) and Adhyarbuda (recurrence) are considered Asadhya (incurable) and these two terminologies may be correlated to the metastatic growth of cancer cells. Management of Arbuda includes all those plants having Laghu, Ruksha and Tikshna Guna may possess Lekhana and Kaphashamak action. © 2022 Nova Science Publishers, Inc..
Toxicity (acute and subacute) assessment and in-vivo antiurolithiatic activity of ethanolic extract of Caesalpinia bonducella seed in albino Wistar rat
(Open Science Publishers LLP Inc., 2022) Ajay Kumar; Manmath Kumar Nandi; Brijesh Kumar; Ashutosh Kumar; Rajesh Kumar; Vikas Kailashiya; Ambrish Kumar Singh
The objective of the present work is to find supportive evidence for the use of Caesalpinia bonducella in nephrolithiasis. For safety assessment of ethanolic extract of seed of C. bonducella (ECB), acute and subacute oral toxicity studies was performed. In the acute oral toxicity study at a dose of 2,000 mg/kg and subacute oral toxicity study at dose of 250, 500, and 1,000 mg/kg, no changes were seen in the behavior, haematological parameters, biochemical parameters, histopathology of major organ, and body weight of rats. The efficacy of ECB at dose of 200 and 400 mg/kg was studied in ethylene glycol, glycolic acid, and sodium oxalate induced urolithiasis in rats and marketed cystone tablet at a dose of 750 mg/kg was used as the standard drug. The mean body weight difference, urinary parameters (urine pH, urine volume, levels of calcium, magnesium, and phosphorus), and serum biochemical parameters [urea, Blood urea nitrogen (BUN), creatinine, uric acid, and alkaline phosphatase] were measured. Urolithiasis caused a significant decrease in mean body weight, pH, and volume of urine and increased in both serum biochemical parameters and urinary electrolyte concentration as compared with the normal control group. Histopathology of kidneys were showed increased glomerular hypercellularity, hydropic tubular degeneration, and cast in the induced control group. Ethanolic Extract of Caesalpinia bonducella (ECB) was found to be effective to normalise the above all changes. It was concluded that the ECB was effective in the prevention and elimination of calcium oxalate crystal deposition into kidneys. © 2022. Ajay Kumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).