Browsing by Author "Amirthalingam Shanthy"

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Effect of lycoriside, an acylglucosyloxy alkaloid, on mast cells
(1986) Shibnath Ghosal; Amirthalingam Shanthy; Mita Mukhopadhyay; Mihir K. Sarkar; Prasun K. Das
The effect of lycoriside, an acylglucosyloxy alkaloid from Crinum asiaticum Linn, (family Amaryllidaceae), with or without sitosterol-3- O-β-D-glucoside, was studied on the rate of degranulation of peritoneal mast cells of albino rats. Lycoriside, at lower concentrations (1–20 µg/ml), in vitro, produced statistically significant protection against Tween 80-induced degranulation, as also to sensitized mast cells challenged with an antigen (horse serum). It also provided protection against compound 48/80-induced degranulation of mast cells when administered in vivo (1–5 mg/kg, po). At higher concentrations (100 µg/ml and above), in vitro, however, it had a mast-cell degranulation effect per se. The addition of sitosterol-3- O-β-D-glucoside to lycoriside did not modify the effect of the latter compound. The mechanism of the dual response elicited by lycoriside is appraised in view of a concentration-dependent anti- or prerelease effect on mast-cell mediators. © 1986, Plenum Publishing Corporation. All rights reserved.
Isocraugsodine, an n-arylidenephenethylamine from Crinum asiaticum and its e-z isomerism
(1988) Shibnath Ghosal; Amirthalingam Shanthy; Sushil K. Singh
A new Schiff's base, named isocraugsodine, was isolated from the fruits of Crinum asiaticum. Its N-(3- methoxy-4-hydroxybenzylidene)- 4′-hydroxyphenethylamine structure was assigned on the basis of chemical trans- formation and comprehensive spectroscopic evidence. The temperature-gradient distribution of the three isomeric forms (1a⇌1b⇌1c) of the Schiff's base was determined by high resolution 1H NMR analysis. Isocraugsodine is considered as a direct precursor to Amaryllidaceae alkaloids. © 1988.
Mast cell stabilizing effect of glucan A and phosphatidyllycorine isolated from Crinum latifolium
(1988) Shibnath Ghosal; Amirthalingam Shanthy; Prasun K. Das; Mita Mukhopadhyay; Mihir K. Sarkar
The effect of glucan A and phosphatidyllycorine, isolated from Crinum latifolium L. (family Amaryllidaceae) was studied on the rate of degranulation of mast cells of albino rats. Different combinations of glucan A and phosphatidyllycorine (5–20 and 5–10 μg/mL, respectively) in vitro, produced statistically significant protection against Tween 80‐induced degranulation, as well as to sensitized mast cells challenged with an antigen (horse serum). The combination (10–20 mg/kg), when administered in vivo, also provided protection against compound 48/80‐induced degranulation of mast cells. The findings are appraised in view of the use of the total extract of C. latifolium, for the treatment of allergic disorders in Ayurvedic medicine. Copyright © 1988 John Wiley & Sons, Ltd.
Palmilycorine and lycoriside: acyloxy and acylglucosyloxy alkaloids from crinum asiaticum
(1985) Shibnath Ghosal; Amirthalingam Shanthy; Anand Kumar; Yatendra Kumar
Two new types of alkaloidal conjugates, a C16-acyloxy derivative, named palmilycorine, and an acylglucosyloxy derivative, named lycoriside, were isolated from the fruits of Crinum asiaticum. The presence of these compounds was also detected in the fleshy scale leaves and in roots of this species. The structures of the two compounds were established as 1-O-palmitoyllycorine (1) and lycorine-1-O-(6′-O-palmitoyl-β-D-glucopyranoside)(2), respectively, on the basis of chemical transformation and comprehensive spectral evidence. The biological effects of the alkaloids were evaluated. © 1985.