Browsing by Author "Amit Bhatia"

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An survey on obesity stigma and its assessment with update: A review
(Plant Archives, 2019) Sagar; Amit Mittal; Dileep Singh Baghel; Saurabh Singh; Amrik Singh; Anand Kumar Chaudhary; Shruti Chopra; Amit Bhatia
Obesity word comes from Latin language "Obesitas" indicates stout, fat or plump nature. The fatness in person more than their usually body requirement or having BMI more than 30 is known as obese person. An obese person is in severe condition that it can lead to further more diseases like hypertension, diabetes, myocardial infarction, peripheral vascular disease, stroke, heart attack, etc. The number of obese persons is increasing day by day in the world. In most of time obesity is caused due to consumption of excessive amount of food and moving deficient. It is due to intake of high energy diet, particularly fat and sugars, however we do not burn off the energy through determine and physical action, abundant of the surplus energy will be accumulated by the human body as fat. It has been detailed that in the event that we adjust the good nourishment and diminishing terrible nourishment such as fast food or junk food and adjusting good life style like waking up and running, gym workout makes a difference to decrease in the obesity. Other strategies are moreover accessible for treating obesity like Acupuncture, Hot spa, Medication but the lifestyle and diet are find to be key role player in treating obesity. In present study a survey questionnaire was planned and reaction was reported online in google form. The study was conducted with 212 people's responses gotten through web against 17 questions/query asked. The questions are related to their life style, diet and medication which is particularly related with their diet propensities. © 2019 Plant Archives. All rights reserved.
Formulation and evaluation of in vitro potential of punarnava ghan tablet against urolithiasis (Mutrakrichra)
(Research Journal of Pharmacy and Technology, 2021) Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Rajesh Kumar; Anand Kumar Chaudhary; Amit Bhatia
Background: Punarnava (B. diffusa Linn.) is usually prescribed in India as traditional medicine in the management of renal miseries including CaOx (calcium oxalate) urolithiasis (Mutrakrichra). It occurs commonly as a weed throughout India. Out of the forty species of this genus B. diffusa, B. chinensis, B. erecta, B. rependa, and B. rubicunda have Indian originates. Objective: To prepare Punarnava ghan tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Punarnava kwath churna were prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kwath. Prepared ghan was compressed into tablet, and for evaluating the quality of tablets standard parameters were determined. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 50 % of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Punarnava ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to so remarkable in vitro activity against Urolithiasis (Mutrakrichra). © RJPT All right reserved.
Formulation, evaluation and assessment of in vitro potential of Gokshur Ghan tablet against urolithiasis (Mutrakrichra)
(Research Journal of Pharmacy and Technology, 2021) Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Anand Kumar Chaudhary; Amit Bhatia; Shruti Chopra
Background: Tribulus species spread in the warm, temperate regions and prevalent in zone where hot summers and dry soil present. Tribulus species comprises of more than 25 species. Tribulus terrestris L. (Zygophyllaceae) consists of ripe, dried, whole fruit and an annual herb, rarely perennial that grows worldwide, particularly in the temperate regions. It is used as traditional medicines in India, China, South Africa, Bulgaria and many other countries. It is used for strengthening (balya), nutritive (brimhan), rejuvenator (rasayan), diuretic (mutral), anti-inflammatory (shothahara), renal calculi (ashmari) and urolithiasis (Mutrakrichra). Objective: To prepare Gokshur tablet and evaluate its potential against Urolithiasis (Mutrakrichra) by in vitro technique. Materials and Methods: Gokshur kvatha churna was prepared as per the methodology mentioned in Sharandhar samhita and ghan was prepared by evaporating the watery portion from prepared kvatha. Prepared ghan was compressed into tablet, and quality of tablets were evaluated. Results: Physicochemical and stability studies have not shown any remarkable variations with prepared tablet dosage form. In vitro studies showed 58.24% of crystal inhibition at 650µg/ml. Conclusion: The prepared tablets of Gokshur ghan did not have remarkable variation during physicochemical and stability studies. The prepared tablets were able to show remarkable in vitro activity against Urolithiasis (Mutrakrichra). © RJPT All right reserved.
In vitro anti-inflammatory and antioxidant activities of Hinguleswara rasa-based herbomineral formulations
(Innovare Academics Sciences Pvt. Ltd, 2018) Abhishek Chatterjee; Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Bimlesh Kumar; Narendra Kumar Pandey; Sachin Kumar Singh; S. Tamilvanan; Shruti Chopra; Amit Bhatia; Anand Kumar Chaudhary
Objective: The aims of the present investigation were to develop the herbal and/or herbomineral formulations of Hinguleswara rasa and to compare their anti-inflammatory and antioxidant activities, in vitro, with that of standard drug samples. Methods: This study was an interventional investigation in three samples: In the first sample, Hinguleswara rasa (HR1) was prepared as per methodology described in Rasatarangini using Shuddha Hingula (10 g), Shuddha Vatsanabha (10 g), and Pippali (10 g). In the second and third sample, respectively, Hinguleswara rasa was prepared by replacing Shuddha Hingula with Kajjali where Kajjali made from Hingulotha parada and Sodhita parada constitutes two varieties of Hinguleswara rasa, i.e. HR2 and HR3. In vitro antioxidant activity was studied using 2,2-diphenyl-1-picrylhydrazyl, and the absorbance was recorded at 517 nm. For evaluating the in vitro anti-inflammatory studies, the inhibition of albumin denaturation technique was performed. Results: The results showed that the formulation of Hinguleswara rasa has shown dose-dependent activity which was observed in 100 µg concentration. HR1, HR2, and HR3 showed 36.11, 17.22, and 16.11% radical scavenging activity. Conclusion: It could be concluded that the changes made in the formulations did not affect the in vitro anti-inflammatory and antioxidant effects of the herbomineral formulations. © 2018, Innovare Academics Sciences Pvt. Ltd. All rights reserved.
In-vitro potential of sphatika tablet in the management of urolithiasis (mutrakrichra)
(Plant Archives, 2020) Dileep Singh Baghel; Amit Mittal; Saurabh Singh; Anand Kumar Chaudhary; Amit Bhatia; Shruti Chopra
The urinary system is mainly embedded of kidneys, ureters, urinary bladder, and urethra. Less water intake, electrolyte imbalance, some bacterial i.e. Escherichia coli & streptococci, viral and parasitic (Dirofilaria immitis) infections, autoimmune diseases might be act as causative factor which finally lead to the development of renal calculi. Sphatika (potash alum) is consider as mutrakrichraghan dravya which helps to break down the calculi and remove them through the urine. In the present work tablets of Sphatika were prepared by using direct compression technique. Crystal growth inhibition started at a concentration of 50 μg/ml but 650 μg/ml of drug showed maximum inhibition of 53.89%. The microbial load and presence of heavy metal in prepared Sphatika tablets was under the limits prescribed by TheAyurvedic Pharmacopoeia of India. © 2020 Plant Archives. All rights reserved.