Browsing by Author "Anamika Das"

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Application of mushrooms in the degradation of xenobiotic components and the reduction of pesticides
(CRC Press, 2022) Karishma Joshi; Anamika Das; Gaurav Joshi; Bibekananda Sarkar
Mushroom enzymatic substrates possess a high structural homology with various xenobiotic chemicals with pharmacophoric features of polycyclic aromatic hydrocarbons, nitrotoluenes pentachlorophenol, pesticides, dioxins, dyes, lignin, and cellulose derivatives. The chapter therefore is kept forth to elaborate the importance of mushroom in mycoremediation. To highlight the importance, the chapter is enriched with broader discussion on essential chemicals and enzymes from mushroom involved in mycoremediation. The need for degradation, mechanism involved along with the numerous factors influencing the bioremediation by mushroom along with its limitations are kept forth. The chapter will provide enough scope for the ecologist, chemists, and environmentalist to explore the mushroom as a game-changer in reducing waste accumulation and, at the same time, explore the possibilities of nutritious food source for an ever-expanding population. © 2022 Sanju Bala Dhull, Aarti Bains, Prince Chawla, and Pardeep Kumar Sadh. All rights reserved.
Comparison of expression of chemokine receptor 4 in maternal decidua and chorionic villi in women with spontaneous miscarriages and women opting for termination of viable pregnancies
(Wolters Kluwer Medknow Publications, 2021) Anamika Das; Nisha Agrawal; Rinchen Zangmo; Kallol Roy; Kiran Singh; Renu Bala
Background: Early pregnancy losses can be a distressing experience both for the parents and the treating clinician. We aim to explore the role of chemokine receptor 4 (CXCR4) in early pregnancy losses by comparing its expression among patients with spontaneous miscarriages and patients undergoing termination of viable pregnancies for unwanted pregnancies. Aim: The aim of the study was to investigate the expression of CXCR4 in early pregnancy losses and correlate the various clinical parameters with differential expression of the above receptor in the chorionic villi and maternal decidua. Study and Setting: The present study is a case-'control study done in a tertiary care center. Methodology: Fifty patients attending outdoor and antenatal clinic of the hospital aged 18-'40 years with spontaneous miscarriage under 20 weeks of gestational age were included as cases and compared with fifty females of comparable age group (18-'40 years) seeking medical termination of pregnancy as controls. Chorionic villi and decidua obtained from the cases and controls were analyzed for CXCR4 expression. Statistical Analysis: The results were analyzed using mean ± standard deviation, percentiles values, Chi-square test, and P value to determine the association of CXCR4 expression in decidua and chorionic villi of cases versus controls. Results: CXCR4 expression was significantly downregulated in cases as compared to the controls with P < 0.001. The mean normalized ratio of CXCR4 expression to housekeeping gene (β Actin) expression in the case group was 1.607 ± 1.108 and in the control group, it was 2.506 ± 1.457. There was a strong correlation between the expression of CXCR4 and maternal age. With increasing age, the expression of CXCR4 was more downregulated in both the cases and control groups (P < 0.001). The expression of CXCR4 was elevated in controls as compared to cases in <30 years age group (P = 0.009). CXCR4 expression was higher in primigravida than in multigravida (P = 0.001), and as the number of previous miscarriages increased, the expression of CXCR4 was found to be decreased (P = 0.021). Conclusion: CXCR4 expression is significantly reduced in women with spontaneous miscarriages in comparison with viable pregnancies. and possibly, therapies targeted at increasing the expression of CXCR4 can be used as a treatment modality for management of spontaneous miscarriages. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.