Browsing by Author "Anand Pandey"

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A pilot study on the role of T-tube in typhoid ileal perforation in children
(2008) Anand Pandey; V. Kumar; Ajay N. Gangopadhyay; Vijai D. Upadhyaya; A. Srivastava; Ram B. Singh
Background: Ileostomy is usually performed for patients of typhoid intestinal perforation with poor general condition, but it is associated with significant morbidity. We have used the T-tube in such patients as an alternative to ileostomy. Methods: This is a prospective evaluation of a cohort of children with proven typhoid intestinal perforation. Patients with multiple perforations and poor general condition were managed with a T-tube inserted into the bowel lumen after closing all distal perforations (group 3). They were compared with patients who had primary closure of perforation (group 1) or bowel resection (group 2) to determine the efficacy of the use of T-tube. Results: The total number of patients for groups 1, 2, and 3 was 51, 4, and 12 (n = 67). The mean number of perforations for the three groups was 1, 3.5 ± 0.58, and 4.25 ± 0.97. The operation time for the three groups was 37.29 ± 3.24, 59.25 ± 3.09, and 59.17 ± 4.17 minutes, respectively. The T-tube was removed after 13.17 days. The mean duration of fistula at T-tube site to heal was 8.58 ± 2.11 days. The overall follow-up period was 10.94 ± 1.15 months and none of the patients with T-tube placement had features of intestinal obstruction. Conclusions: In children with multiple typhoid intestinal perforations and poor general condition, the use of T-tube may be an effective management option. © 2008 Société Internationale de Chirurgie.
Association of oxidative stress and endothelial dysfunction in hypertension
(Academic Press Inc., 2020) Pritee Chaudhary; Anand Pandey; Chandra Shekhar Azad; Neelam Tia; Manish Singh; Indrajeet Singh Gambhir
Background: Biomarkers of oxidative stress (OS) are involved in the pathophysiology of hypertension (HTN) and endothelial dysfunction is also related to HTN. Still, a significant association of OS, as well as endothelial function, remains unclear in HTN. Methods: Totalling 222 North Indian peoples aged 18–80 participated in the study. Of these participants, 74 were elderly hypertensive subjects (age ≥60 years), and 128 were normotensive subjects (age ≥60 years-control I; n = 74, and <60 years-control II; n = 74). OS was assessed by measurement of total oxidant status (TOS) and total antioxidant status (TAS) using a colorimetric and automated method developed by Erel O. Endothelial dysfunction was assessed by measurement of flow-mediated dilation (FMD) using doppler ultrasound system. Results: TOS and OSI were significantly increased and TAS and FMD significantly decreased in patients with HTN as compared to control I and control II. The increase in the level of TOS and a decrease in the level of TAS and FMD were also evident with advancing age. FMD was negatively correlated with TOS and positively correlated with TAS. Conclusion: Decreased TAS level, increased TOS level reflect OS that may be the reason for reduced FMD in elderly hypertensive patients. © 2019 Elsevier Inc.
Chronic bilious vomiting in children in developing countries due to high bowel obstruction: Not always malrotation or tuberculosis
(2010) Anand Pandey; V. Kumar; A.N. Gangopadhyay; S.P. Sharma; S.C. Gopal; D.K. Gupta; S.C.U. Patne
Background: Bilious vomiting, in conjunction with abdominal pain is considered to be a surgical problem, unless proved otherwise. In children, besides tuberculosis (TB), we have found jejunal stricture (JS) due to non-specific jejunoileitis (NSJI) to be an important cause of chronic high small bowel obstruction and bilious vomiting. Materials and methods: In this retrospective study, the records of all children with complaint of intermittent bilious vomiting and failure to thrive were evaluated. Investigations included oral contrast study, ultrasound abdomen, chest X-ray and Mantoux test. Final confirmation was made at laparotomy. Treatment included jejuno-jejunal resection and anastomosis. Histopathology of the specimen was done to look for caseation, granuloma formation and other details. Results: Out of total 100 patients with the complaint of bilious vomiting, 25 were having JS. Radiologic confirmation was possible in 19 (76%) patients of JS. No patient had evidence of TB as per our protocol. Histopathology revealed non-specific ischemic changes in all specimens. Conclusion: Jejunal stricture due to NSJI is a common entity in our setup leading to bilious vomiting. Contrast study can provide high index of suspicion in most of the patients. The diagnosis must be confirmed after proper histopathological examination. The results of the surgery are excellent. © 2009 Springer-Verlag.
Chronic cervical lymphadenopathy in children: Role of ultrasonography
(2012) Anand Pandey; Shiv N. Kureel; Jigyasa Pandey; Ashish Wakhlu; Jiledar Rawat; Tej Bali Singh
Aim: To assess the usefulness of ultrasonography in the differentiation of causes of chronic cervical lymphadenopathy in children. Materials and Methods: Children with palpable cervical lymph nodes were included. An ultrasonographic examination was performed to delineate multiple lymph nodes, irregular margins, tendency towards fusion, internal echos, the presence of strong echoes and echogenic thin layer. Results: The total number of patients was 120. Echogenic thin layer and strong internal echoes were specific for tuberculosis. Long axis to short axis (L/S) ratio was more than 2 in most of the tubercular nodes (85.71%). Hilus was present in 50 (73.53%) tubercular lymphadenitis, 12 (40%) lymphoma and 10 (62.5%) cases with metastatic lymph nodes. Hypoechoic center was present in 60 (88.24%) tubercular lymphadenitis cases followed by 62.5% metastatic and 60% malignant lymphoma cases. Conclusions: Ultrasonography is a non-invasive tool for lymph nodal evaluation in children. It may be used to differentiate cervical lymphadenopathy with different etiologies in children. When correlated clinically, it may avoid biopsy in a patient.
Clinico-immunological response to intratumoral versus intravenous neoadjuvant chemotherapy in advanced pediatric solid malignancies
(Georg Thieme Verlag, 2013) Vijayendra Kumar; Nandini Ramaswami; Anand Pandey; Ram Chandra Shukla; Maloy Ranjan Sen; Shiv Prasad Sharma; Dinesh Kumar Gupta; Ajay Narayan Gangopadhyay
Background: There is minimal literature on the use of intralesional chemotherapy in the pediatric age group. We undertook this present study to evaluate the two modalities (intratumoral and intravenous) of giving chemotherapy in terms of toxicity of chemotherapy, hematological parameters, efficacy of chemotherapy in reduction in volume of the tumor as well as resectability of tumor with special emphasis on immunological parameters. Materials and Methods: Advanced cases of Wilms′ tumor and Neuroblastoma were included in the study. Intratumoral chemotherapy was given through 25 G spinal needle under aseptic precautions and ultrasound guidance in the same dose as in systemic chemotherapy. Intravenous group was given chemotherapy in the usual way. Reassessment was carried out after every course of chemotherapy. Results: Group A included 16 cases of Wilms′ tumor and 6 cases of neuroblastoma. In group B, there were 14 cases of Wilms′ tumor and 8 of neuroblastoma. Vomiting, diarrhea, mucositis, and thrombophlebitis were more common in the intravenous group (P<0.05). The fall in Immunoglobulin A, Immunogloblulin G, Immunoglobulin M, and T-cell rosetting was more common in the intravenous group (P<0.05). Seventy percent of patients had completely resectable tumor at the end of 6 doses of intratumoral chemotherapy as compared to 50% resectability in the intravenous group (P<0.05). Conclusion: Intratumoral chemotherapy, besides causing less of the adverse effects and increasing the resecability rate, also causes less suppression of the immune system. This may be offered as an alternative safe and effective modality of treatment for advanced solid tumors.
Collective and non-collective states in
(Institute of Physics, 2025) A. K. Gupta; Hariprakash P. Sharma; A. K. Rana; Md Anser; Ishika Sharma; S. S. Tiwary; Saikat Chakraborty; C. Majumder; Anupriya Sharma; Anand Pandey; Anuj; S. K. Chamoli; Sanjeev Suresh Kumar; Kaushik T. Katre; Sivaramakrishnan Muralithar; R. P. Singh; Yashraj; Indu Bala; Arunita Mukherjee; Sutanu Bhattacharya; Tarkeshwar Trivedi; Nikhil Mozumdar; Pratyay Banerjee; Subodh; Anil Kumar
The high spin states of 136Ce (Z = 58) were investigated via 124Sn(16O, 4n)136Ce fusion evaporation reaction at MeV. The γ-γ coincidence technique is used for placing the γ-transitions in the level scheme. The spin and parity of the levels have been assigned on the basis of results of the angular correlation and linear polarisation measurements, respectively. The bands based on the yrast 10+ isomeric state and the non-yrast 10+ state have been established. The structures of these bands are also compared with the band structures of the neighbouring nuclei. © © 2025 EPLA. All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Congenital pouch colon associated with anorectal malformation-histopathologic evaluation
(2009) Ajay Narayan Gangopadhyay; Shashikant Chandrakant Urmila Patne; Anand Pandey; Nakul Chandra Aryya; Vijai Dutt Upadhyaya
Background: Although enough literature is available on the descriptive and the management aspects of congenital pouch colon (CPC) associated with anorectal malformation (ARM), there is paucity of its detailed histopathologic studies. The present article details the histopathologic observations in the excised specimens of CPC in the neonates operated on for ARM. Material and Methods: Formalin-fixed specimens of CPC were evaluated both grossly and microscopically. They were stained by H&E stain and Masson trichrome stain. Results: Haustrations and tenia coli were uniformly absent in all the CPC specimens. Mucosa showed focal erosion, hemorrhage, and disruption in the muscularis mucosae. Submucosa showed congested blood vessels, hemorrhage, and thrombosis. Both the circular and the longitudinal muscle layers showed hypertrophic and atrophic appearance. Both the muscle layers also showed disruption. There was presence of fibrosis in all the muscular layers on Masson trichrome stain. There was presence of unique constriction bands in the muscularis propria. These were seen as focal dipping and narrowing of the muscular layers at intermittent intervals. They were more prominent in the circular muscle layers. Conclusion: Congenital pouch colon seen in association with ARM is an abnormally developed tissue and needs to be resected for better functional outcome of the remaining gut. However, further physiologic and immunohistochemical studies are warranted to observe the contractile and innervation pattern of CPC. © 2009 Elsevier Inc. All rights reserved.
Consensus Statement from India on the Renal Benefits of ARNi, SGLT-2i, and Bisoprolol in Chronic Kidney Disease
(Journal of Association of Physicians of India, 2024) H.K. Chopra; Dinesh Khullar; Tiny Nair; G.S. Wander; C.K. Ponde; Saumitra Ray; Navin C. Nanda; Ravi R. Kasliwal; D.S. Rana; Ashok Kirpalani; J.P.S. Sawhney; Praveen Chandra; Yatin Mehta; Viveka Kumar; S. Tewari; A.K. Pancholia; Vijay Kher; Sandeep Bansal; Sanjay Mittal; Praful Kerkar; P.K. Sahoo; Ramesh Hotchandani; Sunil Prakash; Nagendra Chauhan; Vishal Rastogi; A. Jabir; S. Shanmugasundaram; Mangesh Tiwaskar; Ajay Sinha; Vittul Gupta; S.S. Mishra; S.N. Routray; A.K. Omar; Onkar C. Swami; Aparna Jaswal; Shamsad Alam; Rajeev Passey; Rajeeve Rajput; Justin Paul; Aditya Kapoor; D. Prabhakar; Subhash Chandra; Poonam Malhotra; Vivudh Pratap Singh; Manish Bansal; Priyank Shah; Sanjay Jain; Mohan Bhargava; I.B. Vijayalakshmi; Kiron Varghaese; Dharmender Jain; Anupam Goel; Namrata Gaur; Rohit Tandon; Asha Moorthy; Sheeba George; V.K. Katyal; R.R. Mantri; Rahul Mehrotra; Dilip Bhalla; Vinod Mittal; Sarita Rao; Manish Jagia; Harmeet Singh; Surabhi Awasthi; Ameet Sattur; Rekha Mishra; Anand Pandey; Rajeev Chawla; Shalini Jaggi; Blessy Sehgal; Alok Sehgal; Naresh Goel; Ripen Gupta; Samir Kubba; Abhinav Chhabra; Saurabh Bagga; N.R. Shastry
Chronic kidney disease (CKD) is a major contributor to morbidity and mortality in India. CKD often coexists with heart failure (HF), diabetes, and hypertension. All these comorbidities are risk factors for renal impairment. HF and CKD are pathophysiologically intertwined, and the deterioration of one can worsen the prognosis of the other. There is a need for safe renal pharmacological therapies that target both CKD and HF and are also useful in hypertension and diabetes. Neurohormonal activation achieved through the activation of the sympathetic nervous system (SNS), the renin–angiotensin–aldosterone system (RAAS), and the natriuretic peptide system (NPS) is fundamental in the pathogenesis and progression of CKD and HF. Angiotensin receptor neprilysin inhibitor (ARNi), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), and selective β1-blocker (B1B) bisoprolol suppress this neurohormonal activation. They also have many other cardiorenal benefits across a wide range of CKD patients with or without concomitant HF, diabetes, or hypertension. This consensus statement from India explores the place of ARNi, SGLT-2i, and bisoprolol in the management of CKD patients with or without HF and other comorbidities. ©The Author(s). 2024.
Conservative management of ulcerated haemangioma - Twenty years experience
(2009) Anand Pandey; Ajay Narayan Gangopadhyay; Shiv Prasad Sharma; Vijayendra Kumar; Saroj Chooramani Gopal; Dinesh Kumar Gupta
Ulceration is the most common complication of haemangioma and occurs in 5-15% of cases. The present study was carried out to evaluate the clinical features of ulcerated haemangioma and efficacy of the management protocol adopted by us over a period of 20 years. All patients with ulcerated haemangioma were evaluated on the basis of age at presentation, sex, rural or urban distribution and site of haemangioma. Treatment included application of topical antibiotic and systemic antibiotic and analgesic for pain. The total number of patients was 608. The male to female ratio was 1: 2·28. The rural:urban distribution was 2·43:1. The most common site of involvement was head and neck. Mean age of patients was 5·60 ± 2·44 months. Mean size of haemangioma and ulceration was 47·30 ± 20·67 cm2 and 7·49 ± 4·52 cm2, respectively. The mean time for ulcer healing was 40·06 ± 19·41 days. Ulcer size of more than 10 cm2 took more time to heal. Response to treatment was satisfactory. Ulcerated haemangioma usually occurs before completion of 1 year of age; hence, every patient with haemangioma needs careful attention. Adequate treatment and regular follow up brings satisfactory response in the patients. © 2009 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India
(Journal of Association of Physicians of India, 2024) H.K. Chopra; Tiny Nair; G.S. Wander; C.K. Ponde; Saumitra Ray; Dinesh Khullar; Navin C. Nanda; Jagat Narula; Ravi R. Kasliwal; D.S. Rana; Ashok Kirpalani; J.P.S. Sawhney; Praveen Chandra; Yatin Mehta; Viveka Kumar; S. Tewari; A.K. Pancholia; Vijay Kher; Sandeep Bansal; Sanjay Mittal; Praful Kerkar; P.K. Sahoo; Ramesh Hotchandani; Sunil Prakash; Nagendra Chauhan; Vishal Rastogi; A. Jabir; S. Shanmugasundaram; Mangesh Tiwaskar; Ajay Sinha; Vittul Gupta; S.S. Mishra; S.N. Routray; A.K. Omar; Onkar C. Swami; Aparna Jaswal; Shamsad Alam; Rajeev Passey; Rajeeve Rajput; Justin Paul; Aditya Kapoor; D. Prabhakar; Subhash Chandra; Poonam Malhotra; Vivudh Pratap Singh; Manish Bansal; Priyank Shah; Sanjay Jain; Mohan Bhargava; I.B. Vijayalakshmi; Kiron Varghaese; Dharmender Jain; Anupam Goel; Kiran Mehmood; Namrata Gaur; Rohit Tandon; Asha Moorthy; Sheeba George; V.K. Katyal; R.R. Mantri; Rahul Mehrotra; Dilip Bhalla; Vinod Mittal; Sarita Rao; Manish Jagia; Harmeet Singh; Surabhi Awasthi; Ameet Sattur; Rekha Mishra; Anand Pandey; Rajeev Chawla; Shalini Jaggi; Blessy Sehgal; Alok Sehgal; Naresh Goel; Ripen Gupta; Samir Kubba; Abhinav Chhabra; Saurabh Bagga; N.R. Shastry
Heart failure (HF) is a global health concern that is prevalent in India as well. HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). This consensus builds on the updated evidence of the efficacy and safety of SGLT2i in HF and recommends its place in therapy with a focus on Indian patients with HF. ©The Author(s). 2024.
Evaluation and management of infantile hemangioma: An overview
(Ediciones Doyma, S.L., 2008) Anand Pandey; Ajay N. Gangopadhyay; Vijai D. Upadhyay
Infantile hemangiomas are the most common tumors of infancy and commonly last 7 to 9 years. Although their pathophysiology is not completely understood, recent studies have provided useful information regarding differential diagnosis, assessment approaches, and management options. To enhance understanding of infantile hemangiomas and highlight recent advances in knowledge of pathophysiology and newer diagnostic and therapeutic modalities, a literature search of pertinent articles published between 1985 and 2006 in PubMed was conducted using the term hemangioma with the words types, pathophysiology, treatment, and complications. Despite the generally benign nature of the condition, treatment is required for cosmetic and psychological reasons and requires differential diagnosis, particularly with regard to congenital hemangiomas and vascular and non-vascular tumors, to determine cause and address potential complications such as ulceration. Various emerging treatment modalities are available (interferon, vincristine, cyclophosphamide, bleomycin, imiquimod, becaplermin, and laser therapy) but steroids remain the treatment of choice in cases when hemangiomas require intervention. Overall prognosis in terms of healing hemangiomas using conservative measures is good. Additional research to better understand the pathophysiology and role of genetics is needed. Emerging treatment options should be evaluated through controlled studies to assess effects and side effects.
Evaluation of topical steroids in the treatment of superficial hemangioma
(Pulse Marketing and Communications LLC, 2010) Anand Pandey; Ajay N. Gangopadhyay; Shiv P. Sharma; Vijayendra Kumar; Dinesh K. Gupta; S. Chooramani Gopal
Infantile hemangioma is a common disease. Steroids have been used for its treatment; however, intralesional steroids cause pain and other problems. A treatment modality that can avoid these problems is desirable. The authors evaluated the role of topical steroids as an alternative to intralesional steroids in the treatment of superficial hemangioma. Inclusion criteria were <2 superficial type of hemangiomas <5 cm. The topical steroid mometasone furoate was applied twice daily. Intralesional triamcinolone acetonide was injected at monthly intervals using a 24-gauge needle at doses of 1 to 2 mg/kg. Forty-five (86.5%) patients responded to treatment with the topical steroids, of which 50% had excellent and 36.5% had good response. In the intralesional group, the response rate was 95.7%, of which 63.8% had excellent and 31.9% had good response. Complications in the topical steroid group were mild itching and irritation (19.2%) and hypopigmentation (7.6%). Complications in the intralesional group were pain (100%), bleeding (17%), infection (17%), cutaneous atrophy (8.5%), cushingoid facies (2.1%), and growth retardation (2.1%). Topical steroids are a reasonably good alternative to intralesional steroids as an initial choice for treating superficial hemangioma. © 2010 Pulse Marketing & Communications, LLC. All rights reserved.
Fabrication of thin Nb target for lifetime measurements of short lived excited nuclear states
(Elsevier B.V., 2021) Anand Pandey; Ravi Bhushan; Aman Rohilla; C. Majumder; S. Chakraborty; R.P. Singh; Ashutosh Kapil; S.K. Chamoli
The quality of target foils often plays an important role in the success of nuclear physics experiments. Specially, in an experiment intended to measure the level lifetimes of short lived excited nuclear states with Doppler shift attenuation method (DSAM), an isotopically enriched thin target on appropriately thick backing foil of high-Z material is preferentially required. In the present work, a thin (thickness ≈ 0.9 mg/cm2) mono-isotopic Nb target on thick (thickness ≈ 9.2 mg/cm2) lead backing has been prepared using rolling technique at the Inter University Accelerator Center (IUAC), New Delhi. To meet the important criteria of sufficient thickness and proper sticking of two foils without any air gap in-between, some novel methods like heating of stainless steel (SS) pack before rolling, frequent change of rolling pack, use of alcohol during rolling, unidirectional rolling under low pressure specially for rolling lead foil and the composite target, were adopted. The quality check of prepared target foil was done with the energy dispersive X-ray fluorescence (EDXRF) technique. The prepared target has been successfully used in a recent DSAM lifetime measurement experiment at IUAC, New Delhi. © 2020 Elsevier B.V.
Functional evaluation of mid and distal penile hypospadias surgery with special reference to uroflowmetry
(S. Karger AG, 2011) Anand Pandey; Ajay N. Gangopadhyay; Vijayendra Kumar; Shiv P. Sharma; Dinesh K. Gupta; Saroj C. Gopal
Background: To assess two different operative techniques in hypospadias with special emphasis on urinary flow with the help of uroflowmetry. Material and Methods: In this prospective study, all patients underwent either Snodgrass or Mathieu urethroplasty. Preoperative uroflowmetry was done in every patient. Postoperative uroflowmetry was done 2 weeks after stitch removal only in those patients who were not having urethral fistula. Postoperative dilation was done only in those patients who had decreased urinary flow as compared to preoperative values. Results: Fifty patients were included in this 2-year study. Uroflowmetry was performed in 37 patients. Twenty-two patients underwent Snodgrass urethroplasty and the other 15 had Mathieu urethroplasty. Pre- and postoperative Qmax values were 6.57 ± 2.67 and 7.36 ± 3.90 ml/s, respectively. Qavg values were 4.16 ± 1.87 and 4.52 ± 2.50 ml/s, respectively. Although statistically insignificant, the Snodgrass technique appeared to be relatively better than Mathieu's technique. Conclusion: Uroflowmetry can predict the need for dilation in hypospadias. The Snodgrass technique appears to be functionally better than Mathieu's technique. With avoidance of unnecessary trauma due to dilation, the cooperation of pediatric patients can be achieved. © 2011 S. Karger AG, Basel.
Gall bladder perforation as a complication of typhoid fever
(Medknow Publications and Media Pvt. Ltd, 2008) Anand Pandey; Ajay N. Gangopadhyay; Vijayendra Kumar
[No abstract available]
Hydrocephalus
(Springer London, 2010) Ajay N. Gangopadhyay; Vijai D. Upadhyaya; Anand Pandey
Hydrocephalus is an excessive accumulation of cerebrospinal fluid (CSF) within brain cavities (ventricles). Acute hydrocephalus occurs over days, subacute over weeks, and chronic over months or years. It is broadly classified into two groups: Communicating - full communication exists between the ventricles and subarachnoid space. Noncommunicating - CSF flow is obstructed within the ventricular system or in its outlets to the arachnoid space. © 2010 Springer-Verlag London.
Indian Consensus on the Role and Position of Angiotensin Receptor-neprilysin Inhibitors in the Management of Heart Failure
(Journal of Association of Physicians of India, 2024) Hriday Kumar Chopra; Chandrashekhar Ponde; Gurpreet Singh Wander; Tiny Nair; Saumitra Ray; Dinesh Khullar; Navin C. Nanda; Jagat Narula; Ravi R. Kasliwal; Devinder Singh Rana; Ashok Kirpalani; Jitendrapal Singh Sawhney; Praveen Chandra; Yatin Mehta; Viveka Kumar; Satyendra Tiwari; Arvind K. Pancholia; Vijay Kher; Sandeep Bansal; Sanjay Mittal; Praful Kerkar; Prasant Kumar Sahoo; Ramesh Hotchandani; Sunil Prakash; Nagendra Chauhan; Vishal Rastogi; Jabir Abdullakutty; S. Shanmugasundaram; Mangesh Tiwaskar; Ajay Sinha; Vittul Gupta; Shishu Shankar Mishra; Satya Narayan Routray; Ashok Kumar Omar; Onkar C. Swami; Aparna Jaswal; Shamsad Alam; Rajeev Passey; Rajeeve Rajput; Justin Paul; Aditya Kapoor; Prabhakar Dorairaj; Subhash Chandra; Poonam Malhotra; Vivudh Pratap Singh; Manish Bansal; Sanjay Jain; Priyank Shah; Mohan Bhargava; Ishwarappa Balekundri Vijayalakshmi; Kiron Varghaese; Dharmender Jain; Anupam Goel; Kiran Mahmood; Namrata Gaur; Rohit Tandon; Asha Moorthy; Sheeba George; V.K. Katyal; R.R. Mantri; Rahul Mehrotra; Dilip Bhalla; Vinod Mittal; Sarita Rao; Manish Jagia; Harmeet Singh; Surabhi Awasthi; Ameet Sattur; Rekha Mishra; Anand Pandey; Rajeev Chawla; Shalini Jaggi; Blessy Sehgal; Alok Sehgal; Naresh Goel; Ripen Gupta; Samir Kubba; Abhinav Chhabra; Saurabh Bagga; Rajnikant N. Shastry
The incidence of heart failure (HF) in India is estimated to be 0.5–1.7 cases per 1,000 people per year, and approximately 4,92,000–1.8 million new cases are detected every year. Despite the high rate of mortality associated with HF, most patients do not receive maximal guideline-directed medical therapy (GDMT). Current guidelines advocate early multidrug combination therapy with four classes of drugs, namely, beta-blockers (BBs), mineralocorticoid receptor antagonists (MRAs), angiotensin receptor-neprilysin inhibitors (ARNIs), and sodium-glucose transport protein 2 inhibitors (SGLT-2is), particularly in patients with heart failure with reduced ejection fraction (HFrEF). ARNIs reduce cardiac morbidity and mortality in patients with HFrEF. However, recent data indicated that only 4.8% of patients with HFrEF receive ARNI in India. Hence, at a national consensus on HF meeting, cardiology experts from India formulated a national consensus on the use of ARNI in HF based on current evidence and guidelines. The consensus states that ARNI should be used early in HF, particularly in de novo patients with HFrEF, and those with acute decompensated heart failure (ADHF), irrespective of the presence of low systolic blood pressure (SBP) or diabetes. Moreover, those with HFrEF on renin–angiotensin–aldosterone system (RAAS) inhibitors should be switched to ARNI to reduce the risk of repeated hospitalization for HF, worsening HF, and cardiac death, and to improve the quality of life (QoL). Starting ARNI during the first hospitalization is preferable, and it is safe and effective across all doses. ARNIs can also be used for secondary benefits in patients with preserved ejection fraction [heart failure with preserved ejection fraction (HFpEF)] and HF with mildly reduced EF [heart failure with mildly reduced ejection fraction (HFmrEF)]. ©The Author(s). 2024Open Access.
Indications of octupole correlation in 84Sr
(Institute of Physics, 2023) Anuj; S. Kumar; Naveen Kumar; Neelam Rajput; K. Rojeeta Devi; Neeraj Kumar; C.V. Ahmad; Akashrup Banerjee; Aman Rohilla; C.K. Gupta; Anand Pandey; Ravi Bhushan; Unnati Gupta; S.K. Mandal; S.S. Bhattacharjee; Divya Arora; R. Garg; Indu Bala; Rakesh Kumar; R.P. Singh; S. Muralithar; V.V. Jyothi; Chandrani Majumder; Hariprakash Sharma; Anupriya Sharma; S.K. Dhiman
Excited states in the 84Sr nucleus were investigated via the 76Ge(12C,4n)84Sr reaction at a beam energy of 58 MeV. The de-excited γ-rays were detected using the Indian National Gamma Array (INGA) spectrometer at Inter-University Accelerator Center, New Delhi. Directional Correlation from Oriented (DCO) states ratio and the polarization asymmetry (Δ) measurements were done to confirm the spin-parity of the low-lying states. Eight new γ-ray transitions were placed in the level scheme of 84Sr. The systematic behaviour of energy staggering S(I) of the γ-band (Band 1 and Band 2) was compared with the γ-bands in the mass A ≈ 80 region and the nuclei of other mass regions with similar behaviour (odd-I down). The E1 character is confirmed for strong γ-ray transitions connecting Band 3 to the Yrast band. Comparison of new results such as B(E1)/B(E2) ratio, frequency ratio ω −/ω + and energy displacement ΔE in 84Sr with those of 72Se, 150Sm, 152Gd, 220Ra and 224Th nuclei suggests the presence of octupole correlations in 84Sr. © 2023 IOP Publishing Ltd
Investigation of multiple anti-magnetic rotational bands in 106Cd
(Springer, 2025) Diwanshu; Ashok S.k. Kumar; Bharti Rohila; Chetan Kumar Sharma; Subodh; Ishika Sharma; P. S. Rawat; Anand Pandey; Kaushik T. Katre; Honey Arora; U. S. Ghosh; Yashraj; C. Majumder; Hariprakash P. Sharma; S. K. Chamoli; Sanjeev Suresh Kumar; Sivaramakrishnan Muralithar; R. P. Singh
Lifetimes of excited states of positive and negative parity ΔI = 2 bands of 106Cd have been measured using the Doppler Shift Attenuation Method (DSAM). The electric quadrupole reduced transition probability rates, B(E2), show a significant decreasing trend with increasing spin along with large observed ℑ(2)/B(E2) values. The experimental observations, interpreted in the framework of semiclassical particle-rotor model (SCM) calculations, suggest that these bands have the character of twin-shears type anti-magnetic rotational bands resulting from the coupling of g9/2 proton holes with h11/2, g9/2 and d5/2 neutron particles. Another negative-parity band in the same nucleus has been studied using SCM, which also interprets it to be an anti-magnetic rotational band. © The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2025.
Letters to the Editor
(2009) Anand Pandey; Ajay Narayan Gangopadhyay; Vijai Dutt Upadhyay
[No abstract available]