Browsing by Author "Anil B. Ray"

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Additional withanolides of datura metel
(1991) Mohini Gupta; Anjana Bagchi; Anil B. Ray
Withametelin B [2], a new hexacyclic withanolide, has been isolated from the leaves of Datura metel collected from West Bengal, India, and its structure elucidated by chemical and spectroscopic methods. 12-Deoxywithastramonolide [3] and physalindicanol A [4] have also been isolated from this source. © 1991, American Chemical Society. All rights reserved.
Antihyperlipidemic effect of flavonoids from pterocarpus marsupium
(1993) M.A. Farboodniay Jahromi; Anil B. Ray; J.P.N. Chansouria
Serum lipid levels in rats with hyperlipidemia induced by diet as well as by Triton were determined after oral administration of EtOAc extract of Pterocarpus marsupium heartwood and its flavonoid constituents, marsupsin [1], pterosupin [2], and liquiritigenin [3]. Administration of EtOAc extract for 14 consecutive days produced a significant reduction of serum triglyceride, total cholesterol, and LDL- and VLDL-cholesterol levels without any significant effect on the level of HDL-cholesterol. Liquiritigenin and pterosupin were able to effect a significant fall in serum cholesterol, LDL-cholesterol, and atherogenic index, pterosupin being additionally effective in lowering serum triglyceride. © 1993, American Chemical Society. All rights reserved.
Chemical constituents of rhus wallichi
(1986) Subhash C. Sinha; Mahendra Sahai; Anil B. Ray
In our continuing chemical analysis (1,2) of Rhus species, we report here the isolation of three glycosides of quercetin in addition to six other known compounds from the leaves of Rhus wallichi Hook, f. (3,4). © 1986, American Chemical Society. All rights reserved.
Cleomiscosin D, a coumarino-lignan from seeds of Cleome viscosa
(1988) Sandeep Kumar; Anil B. Ray; Chohachi Konno; Yoshiteru Oshima; Hiroshi Hikino
Cleomiscosin D, a minor coumarino-lignan of the seeds of Cleome viscosa, has been proved to be regioisomer of cleomiscosin C. A method of degradation of coumarino-lignans for the identification of the coumarin moiety has been developed. © 1988.
Ethyl brevifolin carboxylate from Flueggea microcarpa
(1991) Hugo E. Gottlieb; Sandeep Kumar; Mahendra Sahai; Anil B. Ray
The leaves of Flueggea microcarpa contain the ethyl ester of brevifolin carboxylic acid. The elucidation of the structure of this isocoumarin involved extensive use of 1H and 13C NMR data, which are fully reported and analysed for the first time; especially useful were long-range CH coupling interactions. NMR parameters for some models, including norbergenin, as well as pyrogallol, gallic acid and their triacetates, are also reported. © 1991.
Flemiculosin, a novel chalcone
(Blackwell Munksgaard, 1999) Kinkini Bhattacharyya; Sunil Kumar Mazumdar; Gabriele Bocelli; Andrea Cantoni; Anil B. Ray; Partha Neogi; Gauri Mazumdar
The title compound, 6-cinnamoyl-5-hydroxy-2,2,8,8-tetramethyl-2H,8H-pyrano[2,3-f]chromene, C25H24O4, is an angular benzodipyran system. It contains a central tricyclic core and a peripheral aromatic ring. The central ring of the tricyclic core is fully substituted while the pyran rings on either side are each unsubstituted at two sites. The central fully substituted ring is planar within 0.014 Å. One pyran ring is planar to within 0.041 Å, but the second pyran ring is only planar to within 0.156 Å; this may be attributed to an intramolecular C - H⋯O contact of 2.30 Å. The structure is stabilized by intramolecular O - H⋯O hydrogen bonds.
Flemiculosin, a novel chalcone. Erratum
(Blackwell Munksgaard, 1999) Kinkini Bhattacharyya; Sunil Kumar Mazumdar; Gabriele Bocelli; Andrea Cantoni; Anil B. Ray; Partha Khattri; Gauri Mazumdar
[No abstract available]
Hypolipidaemic Activity in Rats of Bergenin, the Major Constituent of Flueggea microcarpa
(1992) M. A. Farboodniay Jahromi; J.P.N. Chansouria; Anil B. Ray
Oral administration of bergenin, isolated from the leaves of Flueggea microcarpa, to hyperlipidaemic rats for 14 days significantly decreased serum total lipid without much change in serum cholesterol and triglycerides. However, after 21 days of administration, the serum cholesterol, triglycerides, low‐density lipoprotein (LDL)—and very low‐density lipoprotein (VLDL)—cholesterol levels were significantly reduced while the serum high‐density lipoprotein (HDL)‐cholesterol level was elevated. Bergenin‐treated animals also showed a significant decrease in atherogenic index. Copyright © 1992 John Wiley & Sons, Ltd.
Perulactone, a new ergostane-type steroid from Physalis peruviana (Solanaceae)
(1980) Hugo E. Gottlieb; Isaac Kirson; Erwin Glotter; Anil B. Ray; Mahendra Sahai; Abid Ali
Perulactone, C30H46O7, is the naturally occurring 1-acetate of (20R,22R,24S,25R)-1α,3β,20,22- tetrahydroxyergost-5-en-26,28-olide. It was isolated from a variety of Physalis peruviana growing in India (Varanasi). The carbocyclic moiety was identified by cleavage of the 20,22-bond to give 1α-acetoxy-3β-hydroxypregn-5-en- 20-one. The structure assigned to the side-chain is based on chemical and spectroscopic evidence. This is the first instance when a steroid oxidised at C-28 has been isolated from a Solanaceae plant. Treatment of perulactone with base afford, after acetylation, the corresponding equilibration product (7) (γ-lactone), but no trace of the isomeric 26,22-olide (δ-lactone).
Pharmacological Investigation on Sodium Salt and Acetyl Derivative of Anacardic Acid
(1987) Salil K. Bhattacharya; Meeta Mukhopadhyay; Patchala J. R. Mohan Rao; Anjana Bagchi; Anil B. Ray
Sodium salts of anacardic acid (SA) and O‐acetyl anacardic acid (AA) were subjected to pharmacological screening primarily on paradigms known to be affected by prostaglandin (PG) synthesis inhibitors. Results were compared with those elicited by known cyclo‐oxygenase inhibitors. SA and AA had little discernible effect on general behaviour and showed overt signs of central stimulation in unusually large doses. SA augmented spontaneous motor activity in mice and attenuated hexobarbitone hypnosis in rats. It augmented the convulsant action of pentylene‐tetrazol and inhibited the anticonvulsant effect of phenobarbitone against maximal electroshock‐induced seizures in rats. SA inhibited catalepsy induced by morphine and haloperidol in rats, and antagonized bradykinin‐induced catalepsy when administered intracerebroventricularly (i.c.v.) in rats. Both exhibited significant anti‐inflammatory activity against carrageenin‐induced acute inflammation in rats. This anti‐inflammatory effect was also in evidence when SA was administered i.c.v. SA and AA had no per se effect on rectal temperature in rats but significantly attenuated the hyperthermia induced by i.c.v. bradykinin or i.p. carrageenin. In all these parameters the effects of SA or AA were comparable to those elicited by diclofenac, aspirin or acetaminophen. However, unlike aspirin and diclofenac, which showed significant antinociceptive activity against phenylquinone‐induced writhing technique, SA was additionally effective against radiant heat and thermic stimulation‐induced nocisponsive technique. Both SA and AA appeared to be fairly safe drugs as assessed by acute toxicity studies. Like the cyclo‐oxygenase inhibitor, diclofenac, SA significantly reduced rat brain PGE2 and PGF2α concentrations, as assessed by a radioimmunoassay technique. Pharmacological and biochemical studies indicate that anacardic acid functions as a PG synthesis inhibitor, with the added advantage of having a central analgesic property. Copyright © 1987 John Wiley & Sons, Ltd.
Physalolactone C, A New Withanolide from Physalis Peruviana
(1984) Abid Ali; Mahendra Sahai; Anil B. Ray; David J. Slatkin
A new withanolide, physalolactone C (17S, 20S, 22R-6α-chloro-4β, 5β, 17β, 20αF-tetrahydroxy-1-oxo-ergosta-2,14,24-trienolide) (1), has been isolated and characterized by a study of its physicochemical data and its semisynthesis from physalolactone (2). © 1984, American Chemical Society. All rights reserved.
Pindrolactone, a lanostane derivative from the leaves of Abies pindrow
(Elsevier Ltd, 1996) Manju Tripathi; Luna Jain; Vidya B. Pandey; Anil B. Ray; Gerhard Rücker
Pindrolactone, a new tetracyclic triterpenoid, has been isolated from the leaves of Abies pindrow and its structure advanced as 3α-hydroxylanosta- 7,9(11),22E,24-tetraen-26,23-olide.
Secotropane Alkaloids of Physalis peruviana
(1980) Mahendra Sahai; Anil B. Ray
(+)-Physoperuvine, (±)-physoperuvine, and (+)-V,Ar-dimethylphysoperuvinium salt (anion unknown) were isolated from the roots of Physalis peruviana. Their structures were advanced on the basis of spectral and chemical evidence. These alkaloids comprise the first group of biogenetically interesting secotropane alkaloids. © 1980, American Chemical Society. All rights reserved.
Secowithametelin, a withanolide of Datura metel leaves
(1989) Sujata Kundu; Subhash C. Sinha; Anjana Bagchi; Anil B. Ray
A new withanolide, secowithametelin, has been isolated from the leaves of Datura metel and its structure determined as (20R,22R)-1-oxo-21-hydroxy-27-methoxy-witha-2,5,24-trienolide on the basis of chemical and detailed spectral analysis. © 1989.
Structure of cleomiscosin A, a coumarino-lignoid of Cleome viscosa seeds
(1980) Anil B. Ray; Sunil K. Chattopadhyay; Chohachi Konno; Hiroshi Hikino
Cleomiscosin A, isolated from the seeds of Cleome viscosa, has been shown to be a coumarino-lignoid and its structure has been advanced as I on the basis of chemical and physical evidence. © 1980.
Structures of cleomiscosins, coumarinolignoids of cleome viscosa seeds1 1 Liver-protective drugs. Part 21 of Tohoku University group.
(1985) Anil B. Ray; Sunil K. Chattopadhyay; Sandeep Kumar; Chohachi Konno; Yoshinobu Kiso; Hiroshi Hikino
Structures of cleomiscosins A, B and C, three new coumarino-lignoids isolated from the seeds of Cleome viscosa Linné, have been established as 1a, 2a and 1f irrespectively, on the basis of spectral and chemical evidence. The compounds exhibited liver-protective properties. © 1985.
Withametelin, a hexacyclic withanolide of Datura metel
(1987) Yoshiteru Oshima; Anjana Bagchi; Hiroshi Hikino; Subhash C. Sinha; Mahendra Sahai; Anil B. Ray
Withametelin, a novel hexacyclic withanolide of Datura metel leaves has been characterized as 1 on the basis of spectroscopic studies. © 1987.
Withaminimin, a withanolide from Physalis minima
(1987) Hugo E. Gottlieb; Miriam Cojocaru; Subhash C. Sinha; Mahendra Saha; Anjana Bagchi; Abid Ali; Anil B. Ray
The structure of withaminimin, a new ergostane-type steroid from Physalis minima, was established by spectral analysis (1H and 13C NMR, MS) and chemical transformations, as (20S,22R)-15α-acetoxy-5α,6β,14α-trihydroxy-1-oxowitha-2,16,24-trienolide. An unusual MH2O+ quasi-molecular ion was observed in the chemical ionization mass spectrum of the natural product. © 1987.
Withanolides of Datura fastuosa leaves
(1993) M. Manickam; Anjana Sinha-Bagchi; Subhash C. Sinha; Mohini Gupta; Anil B. Ray
The leaves of Datura fastuosa yielded two new withanolides, withafastuosins A and B, in addition to withametelin, previously reported from D. metel. The structures of the withanolides were established on the basis of detailed spectral and chemical evidence. © 1993.
Withanolides of Datura metel
(1992) Mohini Gupta; M. Manickam; Subhash C. Sinha; Anjana Sinha-Bagchi; Anil B. Ray
The leaves of Datura metel yielded three new withanolides in addition to lycium substance B, previously reported from other Datura species. The structures of the withanolides, clarified by comprehensive spectral analysis, showed features of typical daturalactones as well as of the withanolides of D. metel. p-Hydroxy cinnamic acid amide of tyramine was also isolated. © 1992.