Browsing by Author "Anirban Pal"

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From 1T to 2H: Engineering MoS2 phases through tunable hydrothermal routes
(Elsevier B.V., 2025) Sanjay Kumar Mahla; Swechchha Kesarwani; Anirban Pal
Molybdenum disulfide (MoS2) has attracted a lot of attention in recent years due to its unique structural polymorphism, primarily the semiconducting 2H phase (2H-MoS2) and the metallic 1T phase. The 2H phase is widely employed in optoelectronics, catalysis, and energy storage devices due to its inherent bandgap, while the metallic 1T phase (1T-MoS2) exhibits excellent electrical conductivity and catalytic activity, indicating its potential for use in supercapacitors and hydrogen evolution processes (HER). The ability to tune the phase composition of MoS2 is critical for optimizing its performance in such diverse applications. In this study, we report the controlled synthesis of MoS2 phases using a single hydrothermal process by systematically varying synthesis parameters — such as precursor concentration, reaction time, temperature, and pH — we effectively tuned the energy kinetics governing phase formation. The optimized parameters used for selective synthesis of 2H-MoS2, 1T-MoS2, and mixed-phase compositions. Detailed characterization of the flower like MoS2 Microspheres using X-ray diffraction (XRD), Raman spectroscopy, and transmission electron microscopy (TEM) confirmed the phase purity and morphological features of the synthesized materials. Our work provides a scalable and reproducible approach for phase-engineering of MoS2, enabling its tailored design for targeted applications in energy storage, catalysis, and nanoelectronics. © 2025 Elsevier B.V.
In vivo efficacy and synergistic interaction of 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide, a clerodane diterpene from Polyalthia longifolia against methicillin-resistant Staphylococcus aureus
(2013) Vivek Kumar Gupta; Surjeet Verma; Anirban Pal; Santosh Kumar Srivastava; Pramod Kumar Srivastava; Mahendra P. Darokar
The Staphylococcus aureus bacterium, a nosocomial pathogen often causing untreatable and lethal infection in patients, mutated to become resistant to all the first-line drugs. The present study details the potential of clerodane diterpene 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (CD) isolated from Polyalthia longifolia against methicillin-resistant S. aureus (MRSA) through in vitro and in vivo assays. Minimum inhibitory concentration (MIC) of CD exhibited significant anti-MRSA activity (15.625-31.25 mg/l) against reference strain and seven clinical isolates, while time kill assays at graded MICs indicated 2.78-9.59- and 2.9-6.18-fold reduction in growth of reference strain and clinical isolates of S. aureus, respectively. The combined effect of the CD and 7.5 % NaCl resulted in significant reduction in microbial count within 24 h, indicating the loss of the salt tolerance ability of S. aureus. Further, release of 260-nm absorbing material and flow cytometric analysis revealed an increased uptake of propidium iodide. These assays may indicate the membrane-damaging potential of CD. The molecule CD was found to interact synergistically with clinically used antibiotics (FICI ≤ 0.5) against all clinical isolates. In infected mice, CD significantly (P < 0.001) lowered the systemic microbial load in blood, liver, kidney, lung and spleen tissues and did not exhibit any significant toxicity at 100 mg/kg body weight. © 2013 Springer-Verlag Berlin Heidelberg.