Browsing by Author "Anirban Roy"

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Effect of Stress-WIN, a novel polyherbal formulation, on DOCA-salt-induced hypertensive Wistar rats
(Springer Nature, 2025) Amit Ranjan; Anirban Roy; Poonam Pal; Somesh Agarwal; Amaresh Kumar Singh; Vinod N. Tiwari; Shreyans Kumar Jain; Hitesh Harsukhbhai Chandpa; Ankita Yadav; Sanjeev Kumar
Hypertension is a multifactorial disorder and one of the most important risk factors and a leading cause of stroke, heart disease, and end-organ damage. Hypertension leads to the production of high levels of pro-inflammatory cytokines and cholesterol, which increase thrombogenesis and fibrosis, ultimately resulting in chronic inflammation. Chronic inflammation causes endothelial dysfunction by producing excess reactive oxygen species (ROS) through pro-inflammatory cytokines such as interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α). Further, the high level of nitric oxide (NO) and malonaldehyde (MDA) increases the oxidative stress, which worsens the liver's production of SGOT and SGPT and glomerular filtration of the kidney. In this study, an Ayurvedic polyherbal formulation (StressWIN) was shown to be a potent therapeutic drug for the treatment of deoxycorticosterone (DOCA)-salt-induced hypertension in Wistar rats. This study showed that administration of Stress-WIN significantly reduced the expression of pro-inflammatory cytokines (IL-1β and TNF-α) and also reduced the level of ROS, NO, MDA, SGOT, and SGPT in the serum of DOCA-salt-induced hypertension in Wistar rats. Furthermore, Stress-WIN treatment exhibited reduced cholesterol levels and glutathione concentration. Histological analysis showed that infiltration of immune cells was reversed by Stress-WIN A treatment (500 mg/kg and 1000 mg/kg). Furthermore, Stress-WIN A (2000 mg/kg) administration attenuated DOCA-salt-mediated morphological changes in the kidney and the heart of the Wistar rat. These promising outcomes underscore the potential of Stress-WIN as a viable alternative or adjunct therapy for hypertension, warranting further clinical investigations. © The Author(s) 2025.
In vivo safety assessment of a polyherbal formulation (Stress WIN) proposed for clinical hypertension management
(Springer Nature, 2024) Somesh Agarwal; Anirban Roy; Vinod Tiwari; Poonam Pal; A. Kartika; Rajesh Sharma; Amaresh Kumar Singh; Sanjeev Kumar
Herbal treatments are nowadays considered dietary supplements and nutraceuticals for health maintenance and alternative/complementary therapy. A large range of herbal medications worldwide can easily be accessible in the local market. The polyherbal formulation (Stress WIN) containing Ashwagandha (Withania somnifera L. Dunal), Pushkarmoola (Inula racemosa Hook. F.), and Jatamansi (Nardostachys jatamansi (D. Don) DC.) root has been used empirically in the management of hypertension. However, toxicity data for the StressWIN is not available yet. The present study aims to evaluate the StressWIN’s safety profile by 28 days of repeated dose oral toxicity in Wistar rats. Rats received different doses (500 mg/kg/day, 1000 mg/kg/day, and 2000 mg/kg/day) of StressWIN, for 28 days. The study was conducted in compliance with the OECD guideline 423. No significant differences were observed in hematological and biochemical parameters as compared to the control group (p > 0.05). Histopathological studies revealed no significant alterations in the macroscopic and microscopic architecture of the liver, kidney, heart, and spleen of the StressWIN treated groups in comparison to the control group (p > 0.05). Findings from the present study suggest that StressWIN supplementation has not shown any side effects in terms of sub-acute toxicity in both male and female rats. These findings indicated no observed adverse effect level (NOAEL) of StressWIN was higher than 2000 mg/kg/day. © The Author(s) 2024.
Selenium – An environmentally friendly micronutrient in agroecosystem in the modern era: An overview of 50-year findings
(Academic Press, 2024) Debojyoti Moulick; Arkabanee Mukherjee; Anupam Das; Anirban Roy; Arnab Majumdar; Anannya Dhar; Binaya Kumar Pattanaik; Bhaben Chowardhara; Dibakar Ghosh; Munish Kumar Upadhyay; Poonam Yadav; Swati Hazra; Sukamal Sarkar; Subrata Mahanta; S.C. Santra; Shuvasish Choudhury; Sagar Maitra; Udit Nandan Mishra; Karma L. Bhutia; Milan Skalicky; Oliver Obročník; Viliam Bárek; Marian Brestic; Akbar Hossain
Agricultural productivity is constantly being forced to maintain yield stability to feed the enormously growing world population. However, shrinking arable and nutrient-deprived soil and abiotic and biotic stressor (s) in different magnitudes put additional challenges to achieving global food security. Though well-defined, the concept of macro, micronutrients, and beneficial elements is from a plant nutritional perspective. Among various micronutrients, selenium (Se) is essential in small amounts for the life cycle of organisms, including crops. Selenium has the potential to improve soil health, leading to the improvement of productivity and crop quality. However, Se possesses an immense encouraging phenomenon when supplied within the threshold limit, also having wide variations. The supplementation of Se has exhibited promising outcomes in lessening biotic and abiotic stress in various crops. Besides, bulk form, nano-Se, and biogenic-Se also revealed some merits and limitations. Literature suggests that the possibilities of biogenic-Se in stress alleviation and fortifying foods are encouraging. In this article, apart from adopting a combination of a conventional extensive review of the literature and bibliometric analysis, the authors have assessed the journey of Se in the “soil to spoon” perspective in a diverse agroecosystem to highlight the research gap area. There is no doubt that the time has come to seriously consider the tag of beneficial elements associated with Se, especially in the drastic global climate change era. © 2023 The Authors