Browsing by Author "Anitha Mathews"

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Choroidal melanoma metastasizing to maxillofacial bones
(2007) Manoj Pandey; Om Prakash; Anitha Mathews; Nileena Nayak; Krishnankutty Ramachandran
Background: Melanomas are malignant neoplasm of melanocytic origin, commonly seen on skin and various mucous membranes. Melanomas are the commonest intraocular malignant tumour in the adults. Case presentation: A 50-year-old female presented with complains of painless progressive swelling in right cheek region of two months duration. Examination revealed a 6 × 4 cm bony hard swelling in right zygomatic region near and below lateral canthus of right eye with loss of vision. Investigations revealed it to be a choroidal melanoma metastatising to the zygomatic bone. Patient was successfully treated by surgery. Conclusion: Choroidal melanoma, which commonly metastasizes toliver and lungs, never involves the lymph nodes and metastasis to facial bones is rare. Here we report a case of choroidal melanoma metastasizing to maxillofacial bones. © 2007 Pandey et al; licensee BioMed Central Ltd.
Patterns of mandibular invasion in oral squamous cell carcinoma of the mandibular region
(2007) Manoj Pandey; Latha P. Rao; Shaima R. Das; Anitha Mathews; Elizabeth M. Chacko; B.R. Naik
Background: Mandibular resections are routinely carried out for achieving a R0 resection for oral cancers. However, the need of mandibular resection to achieve this has always been questioned. The present study was carried out to define the pattern of mandibular involvement in carcinoma of the mandibular region. Patients and methods: A total of 25 consecutive patients who had undergone mandibular resection and were found to have mandibular invasion were studied in a prospective open fashion. After decalcification the specimens were serially sectioned at 1 cm interval to identify invasion of mandibular bone. Type of invasion, route of spread and host cell reactions were also recorded. Results: The mandibular involvement was infiltrative in 14(56%) and erosive in 11(44%). It was cortical in 5(20%), marrow involvement was seen in 15(60%) while 5(20%) had spread through the inferior alveolar canal. Of the 25, 24(96%) lesions were located with in 1 cm of the mandible. Conclusion: The possibility of mandibular involvement is higher in patients where tumours are located with in 1 cm of the mandible. Involvement of mandible through the canal of inferior alveolar nerve in the present study was relatively high (20%). Therefore it is recommended that before a decision is taken to preserve the mandible it should be thoroughly screened for possible involvement. © 2007 Pandey et al; licensee BioMed Central Ltd.
Phaeohyphomycosis masquerading as a palatal neoplasm in a patient who is immunocompetent
(BMJ Publishing Group, 2009) Mridula Shukla; Vidyarani; Anitha Mathews; Manoj Pandey
A female patient presented with facial pain, discharge and headache. She had undergone excision of a palatal swelling 2 weeks previously, following which she had developed an oroantral fistula with necrosis of the palate. Imaging studies were suggestive of chronic sinusitis. A biopsy from the maxillary antrum revealed phaeohy phomycosis, a group of fungal infections caused by saprophytic fungi. The patient was treated with antifungal treatment and had a complete response. Phaeohy phomycosis is of rare occurrence in the paranasal sinus and in patients who are immunocompetant. There are only eight previous reports of this occurrence in the literature worldwide.