Browsing by Author "Ankit Kumar Dubey"

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Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey
(Elsevier B.V., 2025) Rajeev K. Singla; Himel Mondal; Shailja Singla; Ronita De; Sahar Behzad; Mihnea Alexandru Gǎman; Siva Sai Chandragiri; Merisa Ćenanović; Jayanta Kumar Patra; Jennifer R. Depew; Boyina Hemanth Kumar; Abdulkadir Yusif Maigoro; Soojin Lee; Omar Mohammad Atrooz; Gitishree Das; Fabien Schultz; Emad M. Abdallah; Hitesh Chopra; Jamil Ahmad; Rupesh Kumar Gautam; Sourav Sanchit Patnaik; Goh Bey Hing; Smith Borakaeyabe Babiaka; Sharad Vats; Michael P. Okoh; Atallah F. Ahmed; Ankit Kumar Dubey; Ronan Lordan; Parasuraman Aiya Subramani; Amit Kumar Singh; José M. Alvarez-Suarez; Dinesh Kumar Chellappan; Shravan Kumar Paswan; Prabhakar Semwal; Johra Khan; Sadeeq Muhammad Sheshe; Neeraj Kumar Sethiya; Tomasz M. Karpiński; Muhammad Ijaz Riaz; Zahra Emam-Diomeh; Girish Kumar Gupta; Reecha Madaan; Suresh Kumar; Neeraj Choudhary; Salvatore Parisi; Harald Willschke; Vasil Radoslavov Pirgozliev; Rehab A. Rayan; Valentin Ritschl; Shaikat Mondal; Gokhan Zengin; Pritt Verma; Bhupinder Kapoor; Monica Gulati; Gareeballah Osman Adam Balla; Dan Khoa Le; Valeria Pittalà; Amr El-Demerdash; Garba Mohammed Khalid; Jesus Simal-Gandara; Qushmua E. Alzahrani; G. L. RUSSO; Kiran R. Kharat; Anupam Bishayee; Dongdong Wang; I. E. Orhan; Hammad Ullah; Michael M. Heinrich; Bikash Baral; Nikolay T. Tzvetkov; Andy Wai Kan Yeung; João Dias-Ferreira; Scarlett Perez Olea; Yugal Kishore Mohanta; Azazahemad A. Kureshi; Claudiu T. Supuran; Neeraj Rani; Rohit Gundamaraju; Eoghan Joseph Mulholland; Sara Di Lonardo; Albena T. Dinkova-Kostova; Elena Ma González-Burgos; Lucian Hriţcu; Pravin Badhe; Abhilasha Singh; Fuad Al-Rimawi; Antoni Sureda Gomila; Rambod Abiri; Nady Braidy; Lorenz Kapral; A. N. Abdullahi; Christhian Delfino Villanueva Medina; Helen Sheridan; Massimo Lucarini; A. Durazzo; Francesca Giampieri; Davide Barreca; Witkowska Anna Maria; J. C. Andrade; Carmela Fimognari
Background: Respiratory tract infections are a common health issue, driving interest in preventive strategies like nutritional supplements, while evidence on their usage and effectiveness remains limited. In this context, social media platforms, particularly X (formerly Twitter), provide a unique opportunity to gather large-scale public health-related data. Objectives: In this study, we aimed to survey participants’ uses and opinions on nutritional supplements in prevention or treatment of respiratory tract infections, by using X. Methods: A survey was conducted between 1st and 15th December 2022. A single open-ended question “Which are the best dietary supplements to counteract respiratory infections?“ was asked. One week after the start of the survey, a poll was posted to get more relevant information and boost the survey's reach. Total endorsements were calculated for each tweet posted as the total sum of replies, retweets, and likes. Results: The open-ended question received a total of 118 retweets, 39 quotes, and 371 likes, while the poll received 56 retweets, 13 quotes, and 67 likes. A total of 495 replies, 2,251 retweets, 5,118 likes, and 148 quotes were received for the question and its related tweets. Vitamin D (1,607 endorsements), zinc (1,347 endorsements), vitamin C (803 endorsements), magnesium (694 endorsements), and honey (661 endorsements) were the nutritional supplements that received most endorsements. Conclusion: Various foods, drinks, and natural ingredients have been suggested as potentially helpful for counteracting respiratory infections. Approximately half of respondents indicated using such supplements for themselves. The result of this study supports the idea that the X platform can be used as an effective survey tool to study global health-related behaviours and trends. © 2025 The Authors
The role of nanomaterials in enhancing natural product translational potential and modulating endoplasmic reticulum stress in the treatment of ovarian cancer
(Frontiers Media S.A., 2022) Rajeev K. Singla; Pooja Sharma; Dinesh Kumar; Rupesh K. Gautam; Rajat Goyal; Christos Tsagkaris; Ankit Kumar Dubey; Himangini Bansal; Rohit Sharma; Bairong Shen
Ovarian cancer, and particularly its most frequent type, epithelial ovarian carcinoma, constitutes one of the most dangerous malignant tumors among females. Substantial evidence has described the potential of phytochemicals against ovarian cancer. The effect of natural compounds on endoplasmic reticulum (ER) stress is of great relevance in this regard. In ovarian cancer, the accumulation of misfolded proteins in the ER lumen results in decompensated ER stress. This leads to deregulation in the physiological processes for the posttranslational modification of proteins, jeopardizes cellular homeostasis, and increases apoptotic signaling. Several metabolites and metabolite extracts of phytochemical origin have been studied in the context of ER stress in ovarian cancer. Resveratrol, quercetin, curcumin, fucosterol, cleistopholine, fucoidan, and epicatechin gallate, among others, have shown inhibitory potential against ER stress. The chemical structure of each compound plays an important role concerning its pharmacodynamics, pharmacokinetics, and overall effectiveness. Studying and cross-comparing the chemical features that render different phytochemicals effective in eliciting particular anti-ER stress actions can help improve drug design or develop multipotent combination regimens. Many studies have also investigated the properties of formulations such as nanoparticles, niosomes, liposomes, and intravenous hydrogel based on curcumin and quercetin along with some other phytomolecules in ovarian cancer. Overall, the potential of phytochemicals in targeting genetic mechanisms of ovarian cancer warrants further translational and clinical investigation. Copyright © 2022 Singla, Sharma, Kumar, Gautam, Goyal, Tsagkaris, Dubey, Bansal, Sharma and Shen.
Unlocking the potential of oncology biomarkers: advancements in clinical theranostics
(Walter de Gruyter GmbH, 2024) Ankit Kumar Dubey; Ishnoor Kaur; Reecha Madaan; Shikha Raheja; Rajni Bala; Manoj Garg; Suresh Kumar; Viney Lather; Vineet Mittal; Deepti Pandita; Rohit Gundamaraju; Rajeev K. Singla; Rohit Sharma
Introduction: Cancer biomarkers have revolutionized the field of oncology by providing valuable insights into tumor changes and aiding in screening, diagnosis, prognosis, treatment prediction, and risk assessment. The emergence of “omic” technologies has enabled biomarkers to become reliable and accurate predictors of outcomes during cancer treatment. Content: In this review, we highlight the clinical utility of biomarkers in cancer identification and motivate researchers to establish a personalized/precision approach in oncology. By extending a multidisciplinary technology-based approach, biomarkers offer an alternative to traditional techniques, fulfilling the goal of cancer therapeutics to find a needle in a haystack. Summary and Outlook: We target different forms of cancer to establish a dynamic role of biomarkers in understanding the spectrum of malignancies and their biochemical and molecular characterization, emphasizing their prospective contribution to cancer screening. Biomarkers offer a promising avenue for the early detection of human cancers and the exploration of novel technologies to predict disease severity, facilitating maximum survival and minimum mortality rates. This review provides a comprehensive overview of the potential of biomarkers in oncology and highlights their prospects in advancing cancer diagnosis and treatment. © 2024 Walter de Gruyter GmbH. All rights reserved.