Browsing by Author "Anubha Jain"

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Langerhans cell histiocytosis: An enigmatic disease
(Wolters Kluwer Medknow Publications, 2019) Anubha Jain; Sushil Kumar; Priyanka Aggarwal; Mohan Kumar; Vineeta Gupta
Background: Langerhans cell histiocytosis (LCH) is a poorly understood disease with heterogeneous clinical presentation ranging from unifocal bony involvement to disseminated disease with life-threatening complications. Materials and Methods: The clinical profile, laboratory findings, treatment, and long-term outcome were retrieved from maintained medical records from January 2006 to January 2016 and were retrospectively analyzed. The extent of the disease was classified as per the LCH-III trial of 'The Histiocyte Society.' The assessment and categorization of treatment response followed LCH III trial definitions. Results: A total of 28 children with LCH were diagnosed. The age ranged between 5 months and 9 years, with a mean of 3 years. The M: F ratio was 3:1. Single system, unifocal and multifocal bone diseases were seen in nine (32.1%) and two (7.1%) cases, respectively. Disseminated disease without risk organ involvement was seen in six (21.1%), whereas disseminated disease with risk organ involvement was seen in 11 (39.3%) cases. The most common presentation was bony involvement (19 [67.8%]), out of which 16 (88.8%) had skull involvement. During follow-up, 17 (60.7%) were in complete remission though five (17.8%) of them relapsed, but achieved second remission. Two (7.1%) were lost to follow-up. Six (21.4%) had progressive disease of which four expired and two abandoned treatment. Two (10.7%) refused the initiation of treatment. Conclusion: A better understanding of the disease, early suspicion, and diagnosis can improve the outcome of patients with LCH. © 2019 Medknow Publications. All rights reserved.
Lipid profile during chemotherapy in children with acute lymphoblastic leukemia
(Wolters Kluwer Medknow Publications, 2021) Dolly Madan; Priyanka Aggarwal; Anubha Jain; Vineeta Gupta
[No abstract available]
Relation between Cardiac T2∗ Values and Electrocardiographic Parameters in Children with Transfusion-dependent Thalassemia
(Lippincott Williams and Wilkins, 2020) Priyanka Aggarwal; Ishan Kumar; Anubha Jain; Ashish Verma; Vineeta Gupta
Background/Objectives:Cardiac T2∗ magnetic resonance imaging (MRI) is the gold standard to determine myocardial iron overload. As availability of Cardiac T2∗ is not uniform across developing nations, our strategy was to identify a more accessible and cost effective tool to assess myocardial iron accumulation. As children with transfusion-dependent thalassemia also experience various electrocardiographic abnormalities, we performed electrocardiography (ECG) as well as Cardiac T2∗ MRI on all children registered in our thalassemia unit.Materials and Methods:Forty-eight transfusion-dependent thalassemia children with transfusion burden ≥12 times/y (6 to 19 y) in the Thalassemia Unit of the Division of Hematology Oncology, Department of Pediatrics were enrolled. Patients were divided into 3 groups based on severity of T2∗ value, that is group I (T2∗<10), group II (T2∗ 10 to 20), group III (T2∗>20). A T2∗ value >20 was taken as normal. ECG and serum ferritin was also performed on the day of MRI.Results:Among the various ECG parameters, QRS duration, and QTc interval were significantly increased if cardiac iron overload was high with a P-value of 0.036 and 0.000, respectively. Also, high serum ferritin predicted a decline in T2∗ value with a P-value of 0.001. QT interval and QTc interval significantly correlated inversely with T2∗ (P=0.042, r=-0.295 and P=0.002, r=-0.446, respectively) but not QRS duration (P=0.05, r=-0.282). Serum ferritin also was found to have a significant inverse correlation with T2∗ value (P=0.000, r=-0.497).Conclusions:Abnormalities on ECG, that is prolongation of QRS duration, QT interval, and QTc interval were significantly associated with cardiac iron overload, that is decrease in the value of Cardiac T2∗ in our study. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Variable Phenotypic Presentation of Two Siblings with Hemoglobin SD Disease
(Springer, 2020) Priyanka Aggarwal; Anubha Jain; O.P. Mishra; Vineeta Gupta
[No abstract available]