Browsing by Author "Archana Pandey"

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Community engagement for healthcare delivery without incentive: sustainable or not for Universal Health Coverage?
(Indian Association of Preventive and Social Medicine, 2025) Archana Pandey; Alok Kumar; Neeraj Agarwal; Anju Bharti; Neeta Kumar; Sangeeta Kansal
Apart from healthcare service delivery, the growing digitalization of health records raises a need to connect every citizen with a digital health ecosystem under the Ayushman Bharat Digital Mission. Considering this fact, an ICMR-funded project, the human resource in the form of Home Health Guides (HHGs) is envisaged to bridge the gap between the community and the health system as complementary to the existing health workforce. These are active volunteers in the community who are educated till matriculation and are willing to work in the field for at least two or three hours without any incentives/remunerations. Their assigned roles are to record and update the health-related information of the assigned families. They are also supposed to assess health emergencies, guide the community regarding their healthcare needs, and link them with the existing healthcare system. As part of the project, we have provided hand-holding support, training, and a few other non-monetary incentives in the form of first aid and medical tool kit, stationary, etc. It was observed that along with the health system, the community also needs the assistance of such a cadre for updating their health records. Also, despite so much effort, these volunteers are not motivated therefore, such initiatives need to be revised and should include monetary incentives to keep them motivated. ©The Author(s). 2025 Open Access.
Design, Synthesis, DFT, docking Studies, and antimicrobial evaluation of novel benzimidazole containing sulphonamide derivatives
(Academic Press Inc., 2024) Kajal Singh; Vishal K. Singh; Richa Mishra; Ashwani Sharma; Archana Pandey; Santosh K. Srivastava; Himani Chaurasia
In silico approaches have been employed to design a new series of benzimidazole-containing sulphonamide derivatives and qualified compounds have been synthesized to analyze their potential as antimicrobial agents. Antibacterial screening of all synthesized compounds was done using the broth microdilution method against several human pathogenic bacteria, viz. Gram-positive bacteria [B. cerus (NCIN-2156), B. subtilis (ATCC-6051), S. aureus (NCIM-2079)] and Gram-negative bacteria [P. aeruginosa (NCIM-2036), E. coli (NCIM-2065), and a drug-resistant strain of E. coli (U-621)], and the compounds presented admirable MIC values, ranging between 100–1.56 µg/mL. The combinatorial analysis showed the magnificent inhibitory efficiency of the tested compounds, acquired equipotent to ten-fold more potency compared to original MIC values. An immense synergistic effect was exhibited by the compounds during combination studies with reference drugs chloramphenicol and sulfamethoxazole was presented as fractional inhibitory concentration (∑FIC). Enzyme inhibition studies of all synthesized compounds were done by using peptidyl transferase and dihydropteroate synthase enzymes isolated from E. coli and S. aureus and each of the compound presented the admirable IC50 values, where the lead compound 3 bound to peptidyl transferase (of S. aureus with IC50 363.51 ± 2.54 µM and E. coli IC50 1.04 ± 0.08 µM) & dihydropteroate synthase (of S. aureus IC50 3.51 ± 0.82 µM and E. coli IC50 2.77 ± 0.65 µM), might account for the antimicrobial effect, exhibited excellent inhibition potential. Antifungal screening was also performed employing food poisoning methods against several pathogenic fungal species, viz A. flavus, F. oxysporum, A. niger, and A. brassicae. The obtained result indicated that few compounds can prove to be a potent drug regimen against dreaded MDR strains of microbes. Structural activity relationship (SAR) analysis and docking studies reveal that the presence of electron-withdrawing, polar, and more lipophilic substituents positively favor the antibacterial activity, whereas, electron-withdrawing, more polar, and hydrophilic substituents favor the antifungal activities. A robust coherence has been found in in-silico and in-vitro biological screening results of the compounds. © 2024 Elsevier Inc.
Formulation and assessment of penetration potential of Risedronate chitosan nanoparticles loaded transdermal gel in the management of osteoporosis: In vitro and ex vivo screening
(Elsevier Ltd, 2024) Sandhya Pathak; Prashant Sahu; J.P. Shabaaz Begum; Sushil K Kashaw; Archana Pandey; Prabhakar Semwal; Rohit Sharma
Osteoporosis targeting by transdermal distribution has drawn a lot of attention as a cutting-edge, environmentally friendly platform for sustainable pain management. We investigate a novel biocompatible transdermal gel (RCNGL) containing biodegradable chitosan nanoparticles and Risedronate (RS) to treat osteoporosis. The RCNGL was formulated using the Pluronic F 127 co-polymer system and the ionic gelation process. The formulation showed a robust architecture of nanoparticle dispersion with a nano-size range of 201.8 nm when it was thoroughly analysed for Scanning Electron Microscopy, Dynamic electron Microscopy and transmission electron microscopy. At various temperatures, the entrapment efficiency was 67.53±1.05% with steady rheology and respectable porosity, validating FT-IR spectra that showed structural compatibility of RS with other excipients. The drug release test resulted in an 88% RS gel release, supporting sustained release kinetics. The ex vivo Franz diffusion study and in vitro cell uptake and distribution experiments revealed clear cell uptake and distribution with notable skin permeation displaying >70% RS release in mouse epidermal tissue. Overall, our research shows that biodegradable RCNGL may offer a potential osteoporosis and pain control strategy in clinical platforms using passive targeting. © 2024
Synthesis, characterization and corrosion inhibition potential of two novel Schiff bases on mild steel in acidic medium
(Royal Society of Chemistry, 2017) Archana Pandey; B. Singh; Chandrabhan Verma; Eno E. Ebenso
The present study deals with the synthesis of two novel Schiff bases (SBs) namely; 5-((4-chloro-3-nitrophenylimino)methyl)-2-methoxyphenol (SB-1) and 2-(4-hydroxy-3-methoxybenzylidineamino)-4-nitrophenol (SB-2) using a solid-liquid phase equilibrium diagram and their characterization via1H and 13C NMR, FT-IR and UV-vis spectral analyses. Differential scanning calorimetric (DSC) thermographs were also obtained to further support the synthesis and identify the melting temperatures of SB-1 and SB-2. The XRD technique was employed to study the atomic packing, crystal structure and space group of the grown crystals of SB-1. Results showed that powder X-ray diffraction patterns of both SBs are entirely different than those of their corresponding starting compounds. The inhibition properties of the investigated SBs were evaluated for mild steel corrosion in 1 M HCl using electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (PDP) and computational (DFT) methods. Electrochemical and DFT studies revealed that the tested SBs act as good inhibitors for acidic corrosion of mild steel and their efficiency increases (η%) on increasing their concentrations. Electrochemical results revealed that SB-1 and SB-2 showed maximum inhibition efficiencies of 95.58% and 96.80%, respectively, at a concentration as low as 0.327 mM. Results from a polarization study suggest that the studied SBs act as mixed type corrosion inhibitors with some cathodic predominance. The DFT based parameters such as EHOMO, ELUMO, ΔE, electronegativity (χ), hardness (η), softness (σ) and the fraction of electron transfer (ΔN) were calculated to corroborate the experimentally obtained results. Both experimental and DFT results were in good agreement. This journal is © The Royal Society of Chemistry.
Synthesis, characterization and corrosion inhibition properties of benzamide–2-chloro-4-nitrobenzoic acid and anthranilic acid–2-chloro-4-nitrobenzoic acid for mild steel corrosion in acidic medium
(Elsevier B.V., 2018) Archana Pandey; Chandrabhan Verma; B. Singh; Eno E. Ebenso
The present study deals with the synthesis of two new compounds namely, benzamide – 2-chloro-4-nitrobenzoic acid (BENCNBA) and anthranilic acid–2-chloro-4-nitrobenzoic acid (AACNBA) using solid phase reactions. The phase diagram studies revealed that formation of the investigated compounds occurs in 1:1 molar ratio. The synthesized compounds were characterized using several spectral techniques such as FT-IR, 1H and 13C NMR, UV–Vis, powder X-ray diffraction (PXRD). Single crystal XRD (SCXRD) study showed that both BENCNBA and AACNBA compounds crystallize in triclinic crystal system with P-1 space group. Further, the presence of intermolecular hydrogen bonding between the constituent components was also supported by single crystal X-ray diffraction (SCXRD) method. Heat of mixing, entropy of fusion, roughness parameter, interfacial energy and excess thermodynamic functions have also been computed using the enthalpy of fusion values derived from differential scanning calorimeter (DSC) study. The inhibition effect of BENCNBA and AACNBA on the mild steel corrosion in hydrochloric acid solution was tested using electrochemical methods. Electrochemical impedance spectroscopy (EIS) study revealed that both BENCNBA and AACNBA behaved as interface corrosion inhibitors and showed maximum inhibition efficiencies of 95.71% and 96.42%, respectively at 400 ppm (1.23 × 10−3 M) concentration. Potentiodynamic polarization (PDP) measurements suggested that BENCNBA and AACNBA acted as mixed type corrosion inhibitors. EIS and PDP results showed that BENCNBA and AACNBA act as efficient corrosion inhibitors for mild steel and their inhibition efficiencies enhances on increasing their concentrations. © 2017 Elsevier B.V.