Browsing by Author "Arpita Mishra"

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Higher-order cranking calculations in the interacting boson model
(1987) Arpita Mishra; A.N. Mantri
It is shown that IBM cranking calculations, carried out by including a time-odd parameter in the definition of intrinsic states of IBM in the lowest order of angular frequency, give reasonably good estimates for the ground-state moment of inertia, but when extended to higher order they produce an unphysical variation of the moment of inertia with frequency. An alternative expression for the ground-state moment of inertia within the IBM framework without using time-odd parameter is briefly discussed. © 1987 IOP Publishing Ltd.
Markers of oxidative stress in children with iron deficiency anemia
(Pediatric Hematology Oncology Chapter of Indian Academy of Pediatrics, 2024) Kusumlata Yadav; Om P. Mishra; Ketki Khandhadiya; Surendra P. Mishra; Arpita Mishra; Ashok Singh; Ritesh K. Agrawal; Nirali Sanghvi; Akash Mishra
Background: Oxidative stress can occur in iron deficiency anemia (IDA), causing cellular injury. The primary objective of the study was to assess serum malondialdehyde (MDA), protein carbonyl as oxidants and glutathione reductase catalase, superoxide dismutase (SOD), and vitamin C levels as antioxidants in patients with IDA and healthy controls; and secondary objectives were to observe the levels among the mild, moderate and severe category of IDA and their correlations with serum iron and ferritin. Material and methods: Fifty-five patients of IDA and 50 healthy controls were enrolled. Diagnosis of IDA was made based on the cut-off values of low hemoglobin as per age, serum iron <30 μg/dL, ferritin <12 ng/mL, and transferrin saturation <16 %. Serum levels of MDA, protein carbonyl, glutathione reductase, catalase, SOD, and vitamin C were estimated. Results: The median age of patients and controls was 6 years. IDA patients had significantly raised mean levels of MDA (p < 0.001) and protein carbonyl (p < 0.001) and decreased glutathione reductase (p < 0.001), catalase (p < 0.001), SOD (p = 0.014) and vitamin C (p = 0.010) than controls. Parameters were comparable among mild, moderate, and severe degrees of IDA. Significantly negative correlations of MDA (r = −0. 713, p < 0.001, −0.683 p < 0.001) and protein carbonyl (r = −0.500, p < 0.001, - 0.519, p < 0.001) and positive correlations of glutathione reductase (r = 0.607, p < 0.001, 0.629, p < 0.001), catalase (r = 0.447, p < 0.001, 0.436, p < 0.001), SOD (r = 0.209, p = 0.032, 0.175, p = 0.075) and vitamin C (r = 0.233,p = 0.017, 0.197, p = 0.044) were observed with serum iron and ferritin, respectively. Conclusion: Oxidative stress exists in patients with IDA, unaffected by the severity of anemia, and has significant correlations with serum iron and ferritin concentrations. © 2024 Pediatric Hematology Oncology Chapter of Indian Academy of Pediatrics
Spectrum of Neurodegeneration with Brain Iron Accumulation with PLA2G6 Variation: A Report of Three Cases from Two Families
(Georg Thieme Verlag, 2023) Shivangi Puri; Ritesh K. Agrawal; Ankur Singh; Ashish Verma; Arpita Mishra; Ashok Singh; Raghvendra Narayan; Om P. Mishra
Neurodegeneration with brain iron accumulation consists of disorders characterized by progressive neuronal degeneration, cognitive decline, brain iron accumulation in extrapyramidal system, dentate nucleus, and gray and white matters boundary. We present a case series of PLA2G6 -associated neurodegeneration (PLAN), with definite PLA2G6 gene mutations in two cases and suspected in one case. Diagnosis was based on clinical presentations, brain magnetic resonance imaging (MRI) findings, and detection of PLA2G6 mutations. Case 1: An 8-year-old boy presented with weakness of lower limbs, subnormal intelligence, scanning speech, spasticity, dysdiadochokinesia, pendular knee jerk, and extensor plantar reflex. MRI of the brain showed diffuse cerebellar atrophy and white matter T2 hyperintensity with iron deposition in bilateral globus pallidi. Case 2: Elder sister of Case 1, who developed ataxia at the age of 6 years and became bedridden at 14 years. She had nocturnal enuresis, seizures, cervical dystonia, dysphagia, and died at 23 years of age. MRI showed cerebral and cerebellar atrophies and iron deposition in basal ganglia and substantia nigra. Case 3 had infantile onset with quadriparesis, optic atrophy, developmental delay, cerebral and cerebellar atrophies, and brain iron accumulation in basal ganglia. Case 1 revealed two heterozygous mutations of PLA2G6 gene in exons 16 (c.2264G > A, p. Arg755Gln) and 12 (c.1637G > A, p. Arg546Gln), classified as likely pathogenic. Elder sister (Case 2) could not be tested for this mutation. Case 3 showed homozygous silent splice site point variation in exon 7 (c.1077 G > A; p. Ser 359 Ser) of PLA2G6 gene. Thus, in patients presenting with neurodegeneration and imaging findings of brain iron accumulation, diagnosis can be established by PLA2G6 gene mutation analysis. © 2023 Georg Thieme Verlag. All rights reserved.
Variable moment of inertia in the interacting boson model
(1988) Arpita Mishra; A.N. Mantri
We present a simple prescription for the determination of the nuclear softness parameter, a measure of low-spin variation of the moment of inertia, in the interacting boson model. The formulation makes use of explicit dependence of the moment of inertia on the d-boson mixing parameter. The systematics of the softness parameter are carried out using an effective interacting boson model Hamiltonian approach and results are found to be in excellent agreement. © 1988 The American Physical Society.