Browsing by Author "Arvind Kumar Sharma"

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Educational and Socioeconomic Correlates of Stroke Risk Behaviors: Findings from the SPRINT INDIA Trial
(Wolters Kluwer Medknow Publications, 2025) Shweta Jain Verma; Gurnoor Kaur; Arya Devi; Deepti Arora; Aneesh Dhasan; Padmavathyamma Narayanapillai Sylaja; Dheeraj Khurana; Vijaya Pamidimukkala; Biman Kanti Ray; Vivek Keshavan Nambiar; Sanjith Aaron; Gaurav Kumar Mittal; Sundarachary Nagarjunakonda; Aparna Ramakrishna Pai; Sankar Prasad Gorthi; Somasundaram Kumaravelu; Yerasu Muralidhar Reddy; Sunil K. Narayan; Nomal Chandra Borah; Rupjyoti Das; Girish Baburao Kulkarni; Vikram Huded; Thomas Mathew; Mv Padma Srivastava; Rohit Bhatia; Pawan Kumar Ojha; Jayanta Roy; Sherly Mary Abraham; Anand Girish Vaishnav; Arvind Kumar Sharma; Sheikh Jabeen; Abhishek Pathak; Sanjeev Kumar Bhoi; Sudhir Sharma; Sulena Sulena; Aralikatte Onkarappa Saroja; Neetu Ramrakhiani; Madhusudhan Byadarahalli Kempegowda; Mahesh Pundlik Kate; Tina K. George; Ivy Anne Sebastian; Meenakshi Sharma; Rupinder Singh Dhaliwal; Rahul Huilgol; Jeyaraj Durai Pandian
Background and Objectives: Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India (SPRINT INDIA) trial was a randomized control trial that enrolled 4298 stroke patients and administered educational interventions at 31 centers across India, with the aim to reduce recurrent stroke through increased stroke knowledge. This SPRINT INDIA trial post hoc study aims to investigate the incidence of recurrent stroke, high-risk transient ischemic attack (TIA), acute coronary syndrome (ACS), death, and lifestyle behavioral factors at 1 year. In addition, it examines the relationship between patients' baseline characteristics and education levels, risk factors, and outcomes and performs subgroup analysis within the intervention and control groups. Methods: Participants were randomly assigned (1:1) to either intervention or control group through computer-based randomization on web. Intervention included stroke prevention Short Message Service messages, short-duration videos, and printed workbooks. Baseline assessments captured demographic and educational data, classifying patients into three categories: no schooling, less than high school, and high school or above. Primary outcome was a composite of recurrent stroke, high-risk TIA, ACS, and mortality at 1 year. Chi-square tests and analysis of variance were used to evaluate educational disparities across various variables. Results: The intervention did not reduce primary outcomes at 1 year among patients with different educational levels. Higher educational group was associated with enhanced medication adherence (94.3% vs 85.4%; P < 0.001), increased physical activity (5497.91 ± 4117.7 vs 6169.91±4828.8; P < 0.001), lower triglyceride levels, and decreased engagement in behavioral risk factors like alcohol intake (5.1% vs 6.8%; P = 0.013) and tobacco use (smoked and chewed) (4% vs 7.9%; P < 0.001 and 5.8% vs 11.6%; P = 0.020). Conclusions: Personalized secondary stroke prevention, tailored to educational levels, is crucial for effective stroke management. © 2025 Annals of Indian Academy of Neurology.
Effect of zinc additive on thermal transport properties of novel multicomponent chalcogenide Se–Te–Sn system: transient plane source technique
(Springer Science and Business Media B.V., 2025) Deepak Kumar; Krishna Pal; Arvind Kumar Sharma; Horesh Kumar; Kedar A.P. Singh; Sunil Prashanth Kumar
This research delves into the thermal transport characteristics of the novel quaternary chalcogenide Se90-xTe5Sn5Znx (0 ≤ x ≤ 9) (STSZ) network, which was prepared using the melt-quenching method. Measurements of effective thermal conductivity (λe), effective thermal diffusivity (χe), and specific heat per unit volume (ρCp) for twin pellets of STSZ chalcogenide glasses (ChGs) were conducted at ambient temperature by employing the transient plane source (TPS) technique. The observed a non-monotonous trend in the values of λe, χe and ρCp related to 3 at. mass% and 6 at mass% of Zn concentration in the quaternary compositions accredited to the formation of higher-order cross-linking. The two structural units at 3 at mass% and 6 at mass% of Zn are considered as critical (threshold) compositions at which the quaternary STSZ network turns into a chemically ordered alloy. Also, the observed discrepancies in thermal transport characteristics reliant upon composition can be connected to the structural relaxation phenomena of the multicomponent network of STSZ. In addition, a topological framework knowledgeable in constraint theory can provide inclusive clarification for the variations in the thermal transport properties of the STSZ network. © Akadémiai Kiadó Zrt 2025.
Exploring 32 % efficiency of eco-friendly kusachiite-based solar cells: A numerical study
(Elsevier Ltd, 2025) Sumit Choudhary; Rahutosh Ranjan; Manish Nath Tripathi; Neelabh Srivastava; Arvind Kumar Sharma; Mashamichi Yoshimura; Li Chang; Rajanish Nath Tiwari
Recently, solar cells have appeared as a promising solution to meet the increasing energy demand. However, their large-scale commercial use is limited by issues such as toxicity (Cd, Pb, etc), high manufacturing costs, lower stability, and low efficiency. In this perspective, kusachiite solar cells (KSCs) are environmentally friendly, long-term stable, and easy to manufacture. Thus, in this work, kusachiite (CuBi2O4) is used as an absorber layer, with NiO and SrTiO3 serving as the hole transport material (HTM) and an electron transport layer (ETL), respectively. The KSCs, with a structure of FTO/SrTiO3/CuBi2O4/NiO/Au, are numerically simulated. Maximum power conversion efficiency is achieved by optimizing several photovoltaic parameters, such as the thickness and doping density of the ETL, absorber, and HTM. The optimized thicknesses for the HTL, absorber layer, and ETL are 1.5 μm, 2.28 μm, and 0.02 μm, respectively. The designed KSCs exhibit an efficiency eta (η) of 31.89 %, an open-circuit voltage (Voc) of 1.31 V, a short-circuit current (Jsc) of 28.58 mA/cm2, and a fill factor (FF) of 84.99 %. © 2024
SCAPS study on the effect of various hole transport layer on highly efficient 31.86% eco-friendly CZTS based solar cell
(Nature Research, 2023) Rahutosh Ranjan; Nikhil Anand; Manish Nath Tripathi; Neelabh Srivastava; Arvind Kumar Sharma; Masamichi Yoshimura; Li Chang; Rajanish N. Tiwari
Copper Zinc Tin Sulphide (CZTS) is a propitious semiconductor for active absorber material in thin-film solar cells (SCs). Here, SC architecture comprising FTO/ZnS/CZTS/variable HTLs/Au is discussed. Fluorine-doped tin oxide (FTO) and gold (Au) are used as front and back contacts, respectively. Zinc sulphide (ZnS) is used as an active electron transport layer (ETL), while different Cu-based materials (Cu2O, CuO, CuI, and CuSCN) are used as hole transport layers (HTL). A one-dimensional solar cell capacitance simulator (SCAPS-1D) is utilized to simulate the SC structure. Among different Cu-based HTLs, Cu2O is preferred as a potential candidate for high cell performance of CZTS-based SC. The effects of various layer parameters such as thickness, doping density, and carrier concentrations, electron affinity of HTL and absorber, respectively, are also discussed. After optimization of the device, variation of operating temperature and the effect of series and shunt resistance are also taken into consideration. The optimized results of thickness and acceptor concentration (NA) of absorber material are 1.5 µm and approx. 1.0 × 1019 cm−3, respectively. In addition, the function of HTL (with and without) in the designed SC structure is also studied. Capacitance–voltage (C–V) characteristics are also discussed to get an insight of built-in potential. We have achieved cell performances viz. efficiency = 31.86%, short circuit current density = 32.05 mA/cm2, open circuit voltage = 1.19 V, and fill factor = 83.37%. © 2023, The Author(s).
SPRINT INDIA: Regional Variations in Primary and Secondary Stroke Outcomes Based on Baseline Characteristics in North and South Indian Sites
(Wolters Kluwer Medknow Publications, 2025) Somasundaram Kumaravelu; Shweta Jain Verma; Rimpi Arora; Deepti Arora; K. S. Arya Devi; Aneesh Dhasan; Padmavathyamma Narayanapillai Sylaja; Dheeraj Khurana; Pamidimukkala Vijaya; Biman Kanti Ray; Vivek Keshavan Nambiar; Sanjith Aaron; Gaurav Kumar Mittal; Sundarachary Nagarjunakonda; Aparna Ramakrishna Pai; Yerasu Muralidhar Reddy; Sunil K. Narayan; Nomal Chandra Borah; Rupjyoti Das; Girish Baburao Kulkarni; Vikram Huded; Thomas Mathew; Madakasira Vasantha Padma Srivastava; Rohit Bhatia; Pawan T. Ojha; Jayanta Roy; Sherly Mary Abraham; Anand Girish Vaishnav; Arvind Kumar Sharma; Shaikh Afshan Jabeen; Abhishek Pathak; Sanjeev Kumar Bhoi; Sudhir Sharma; Sulena Sulena; Aralikatte Onkarappa Saroja; Neetu Ramrakhiani; Madhusudhan Byadarahalli Kempegowda; Sankar Prasad Gorthi; Mahesh Pundlik Kate; Tina K. George; Ivy Anne Sebastian; Meenakshi Sharma; Rupinder Singh Dhaliwal; Rahul Huilgol; Jeyaraj Durai Pandian
Background and Objectives: Regional differences in stroke prevalence and outcomes in India, driven by demographic and risk factors, are crucial for guiding effective prevention and management strategies. This subanalysis of Secondary prevention with a structured semi-interactive stroke prevention package in INDIA (SPRINT INDIA) randomized controlled trial compared the demographics, risk factors, and clinical outcomes of stroke patients from North and South India to identify regional differences and inform targeted interventions for stroke prevention. Methods: The study analyzed data of 4298 participants from 31 stroke centers across India, focusing on demographics, stroke types, and risk factors. In this study, Mumbai, located at 19.07°N in western India, serves as the dividing line between North and South India. One-year follow-up data from 3038 patients were utilized to examine regional disparities between North and South India. Results: South Indian stroke patients were predominantly rural (60.1%) and less educated (58.2%), while North Indian patients were mostly urban (64.2%). South Indian patients had higher incidence of ischemic stroke (91.1% vs. 73.5%, P = 0.001) and higher rates of large artery atherosclerosis (33.6% vs. 19.7%, P = 0.001), hypertension, type 2 diabetes, smoking, and alcohol consumption, but better medication adherence. In contrast, North Indian patients had higher high-density lipoprotein, drug use, and tobacco use. At 1-year follow-up, North Indian patients had more high-risk transient ischemic attacks and poorer lifestyle-related outcomes, despite South Indians having higher systolic blood pressure and fasting glucose levels. Conclusion: Region-specific strategies are crucial. Block randomization may help. South India needs better lifestyle modification programs, while North India requires improved health education and medication adherence strategies. © 2025 Annals of Indian Academy of Neurology.
The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
(Elsevier GmbH, 2023) Rajeev K. Singla; Ronita De; Thomas Efferth; Bruno Mezzetti; Md. Sahab Uddin; Sanusi; Fidele Ntie-Kang; Dongdong Wang; Fabien Schultz; Kiran R. Kharat; Hari Prasad Devkota; Maurizio Battino; Daniel Sur; Ronan Lordan; Sourav S Patnaik; Christos Tsagkaris; Chandragiri Siva Sai; Surya Kant Tripathi; Mihnea-Alexandru Găman; Mosa E.O. Ahmed; Elena González-Burgos; Smith B. Babiaka; Shravan Kumar Paswan; Joy Ifunanya Odimegwu; Faizan Akram; Jesus Simal-Gandara; Mágali S. Urquiza; Aleksei Tikhonov; Himel Mondal; Shailja Singla; Sara Di Lonardo; Eoghan J Mulholland; Merisa Cenanovic; Abdulkadir Yusif Maigoro; Francesca Giampieri; Soojin Lee; Nikolay T. Tzvetkov; Anna Maria Louka; Pritt Verma; Hitesh Chopra; Scarlett Perez Olea; Johra Khan; José M. Alvarez Suarez; Xiaonan Zheng; Michał Tomczyk; Manoj Kumar Sabnani; Christhian Delfino Villanueva Medina; Garba M. Khalid; Hemanth Kumar Boyina; Milen I. Georgiev; Claudiu T. Supuran; Eduardo Sobarzo-Sánchez; Tai-Ping Fan; Valeria Pittala; Antoni Sureda; Nady Braidy; Gian Luigi Russo; Rosa Anna Vacca; Maciej Banach; Gérard Lizard; Amira Zarrouk; Sonia Hammami; Ilkay Erdogan Orhan; Bharat B. Aggarwal; George Perry; Mark JS Miller; Michael Heinrich; Anupam Bishayee; Anake Kijjoa; Nicolas Arkells; David Bredt; Michael Wink; Bernd l. Fiebich; Gangarapu Kiran; Andy Wai Kan Yeung; Girish Kumar Gupta; Antonello Santini; Massimo Lucarini; Alessandra Durazzo; Amr El-Demerdash; Albena T. Dinkova-Kostova; Alejandro Cifuentes; Eliana B. Souto; Muhammad Asim Masoom Zubair; Pravin Badhe; Javier Echeverría; Jarosław Olav Horbańczuk; Olaf K. Horbanczuk; Helen Sheridan; Sadeeq Muhammad Sheshe; Anna Maria Witkowska; Ibrahim M. Abu-Reidah; Muhammad Riaz; Hammad Ullah; Akolade R. Oladipupo; Víctor Lopez; Neeraj Kumar Sethiya; Bhupal Govinda Shrestha; Palaniyandi Ravanan; Subash Chandra Gupta; Qushmua E. Alzahrani; Preethidan Dama Sreedhar; Jianbo Xiao; Mohammad Amin Moosavi; Parasuraman Aiya Subramani; Amit Kumar Singh; Ananda Kumar Chettupalli; Jayanta Kumar Patra; Gopal Singh; Tomasz M. Karpiński; Fuad Al-Rimawi; Rambod Abiri; Atallah F. Ahmed; Davide Barreca; Sharad Vats; Said Amrani; Carmela Fimognari; Andrei Mocan; Lucian Hritcu; Prabhakar Semwal; Md. Shiblur Rahaman; Mila Emerald; Akinleye Stephen Akinrinde; Abhilasha Singh; Ashima Joshi; Tanuj Joshi; Shafaat Yar Khan; Gareeballah Osman Adam Balla; Aiping Lu; Sandeep Ramchandra Pai; Imen Ghzaiel; Niyazi Acar; Nour Eddine Es-Safi; Gokhan Zengin; Azazahemad A. Kureshi; Arvind Kumar Sharma; Bikash Baral; Neeraj Rani; Philippe Jeandet; Monica Gulati; Bhupinder Kapoor; Yugal Kishore Mohanta; Zahra Emam-Djomeh; Raphael Onuku; Jennifer R. Depew; Omar M. Atrooz; Bey Hing Goh; Jose Carlos Andrade; Bikramjit Konwar; V.J. Shine; João Miguel Lousa Dias Ferreira; Jamil Ahmad; Vivek K. Chaturvedi; Krystyna Skalicka-Woźniak; Rohit Sharma; Rupesh K. Gautam; Sebastian Granica; Salvatore Parisi; Rishabh Kumar; Atanas G. Atanasov; Bairong Shen
Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled “International Natural Product Sciences Taskforce” (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week “2021 INPST Twitter Networking Event” (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events. © 2022 The Author(s)