Browsing by Author "Ashish Badiye"

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A study of genomic diversity in populations of Maharashtra, India, inferred from 20 autosomal STR markers
(BioMed Central Ltd, 2021) Ashish Badiye; Neeti Kapoor; R.K. Kumawat; Shivani Dixit; Aditi Mishra; Akansha Dixit; Prachi Kathane; Sudeshna Bag; Vaishnavi Thakre; Kamlesh Kaitholia; Ankit Srivastava; Gyaneshwer Chaubey; Pankaj Shrivastava
Objective: This study was planned to evaluate the genetic diversity in the admixed and Teli (a Hindu caste) populations of Maharashtra, India using 20 autosomal Short Tandem Repeat (STR) genetic markers. We further investigated the genetic relatedness of the studied populations with other Indian populations. Results: The studied populations showed a wide range of observed heterozygosity viz. 0.690 to 0.918 for the admixed population and 0.696 to 0.942 for the Teli population. This might be due to the multi-directional gene flow. The admixed and Teli populations also showed a high degree polymorphism which ranged from 0.652 to 0.903 and 0.644 to 0.902, respectively. Their combined value of matching probability for all the studied loci was 4.29 × 10–25 and 5.01 × 10–24, respectively. The results of Neighbor-Joining tree and Principal Component Analysis showed that the studied populations clustered with the general populations of Jharkhand, UttarPradesh, Rajasthan and Central Indian States, as well as with the specific populations of Maharashtra (Konkanastha Brahmins) and Tamil Nadu (Kurmans). Overall, the obtained data showed a high degree of forensic efficacy and would be useful for forensic applications as well as genealogical studies. © 2021, The Author(s).
Genetic diversity and forensic characterization of 15 autosomal microsatellite markers in the North-east Indian Tripuri population
(Springer Science and Business Media Deutschland GmbH, 2021) Subhankar Nath; R.K. Kumawat; Ashish Badiye; Ankit Srivastava; Hirak Ranjan Dash; Shivani Dixit; Kamlesh Kaitholia; Gyaneshwer Chaubey; Pankaj Shrivastava
This study was conducted to explore the genomic diversity and forensic characterization of 15 autosomal microsatellite markers in the East Indian Tripuri population. In the studied population, we observed 158 different alleles with the average 10.53 alleles per locus. The locus D2S1338 (PIC= 0.862) was found to be the most polymorphic wheres locus TPOX (PIC= 0.647) as the least polymorphic, among all the studied loci. The locus FGA was found with the highest number of effective alleles (Nall=19) whereas locus TH01 showed least number of effective alleles (Nall=6). The cumulative values for matching probability (CPm), power of discrimination (CPD), power of exclusion CPE), and paternity index (CPI) were found as 1.94×10−18, 1, 0.999998, and 4.8×105 respectively. The studied population showed genetic closeness with the Gorkha population. In neighbor-joining tree, Tripura population pooled with the population of Nepal and Tibet. The genetic data obtained from the present study will not only enrich the existing autosomal STR database but will also be useful for forensic DNA application and genealogical studies. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.