Browsing by Author "Ashok Kumar Pachar"

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Investigating the hypothesis role of the hidden poison microplastics in lymphoma development
(Springer Nature, 2025) Naveen Kumar; Ashok Kumar Pachar; Jayendra Kumar Singh; Mrinmoy Mandal; Mridul Lamba; Sonal Yadav; Neetu Sharda; Arbind Acharya
Microplastics, ranging from 1 micron to 5 mm in size, ubiquitous environmental pollutants, arise from diverse sources such as industrial processes, personal care products, textiles, and urban runoff, permeating air, soil, freshwater, sediment, and marine environments. Human exposure occurs through ingestion, inhalation, and dermal contact, leading to health concerns including oxidative stress, metabolic disruption, and immune modulation, with potential direct links to lung, skin, and digestive cancers. While direct evidence linking microplastics to lymphoma remains elusive, therefore we hypothesized that bloodstream's immediate exposure post-entry suggests a plausible indirect link. This review explores mechanisms around our hypothesis by which microplastics might contribute to lymphoma, encompassing inflammation, oxidative stress, immune dysregulation, endocrine disruption, and genotoxicity. Understanding these pathways is crucial given lymphoma's global impact. Future research warrants comprehensive epidemiological studies and interdisciplinary approaches, integrating epidemiology, experimental research, and computational modeling to elucidate the association between microplastics and lymphoma. © The Author(s) 2025.
Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms
(Springer, 2024) Naveen Kumar; Mridul Lamba; Ashok Kumar Pachar; Sonal Yadav; Arbind Acharya
In today’s world, the widespread presence of microplastics is undeniable, with concentrations found in various environments, including up to 1000 particles per liter in seawater and up to 10 particles per cubic meter in the atmosphere. Originating from diverse sources, both intentional and unintentional, these minuscule fragments, measuring less than 5 mm, pose significant threats to environmental and human health. Recent research has uncovered a concerning link between microplastics and cancer, prompting urgent investigation. Studies demonstrate microplastics can infiltrate cells, disrupt biological processes, and potentially foster carcinogenic environments. From inducing DNA damage and oxidative stress to triggering inflammatory responses and dysregulating cellular pathways, microplastics exhibit a multifaceted capability in contributing to cancer development. Furthermore, microplastics act as carriers for a range of contaminants, compounding their impact on human health. Their accumulation within tissues and organs raises concerns for short and long-term health consequences, including chronic diseases, reproductive issues, and developmental abnormalities. This review explores the biochemical and molecular mechanisms underlying the interaction between microplastics and cellular systems, providing insights into routes of exposure and health effects, with a focus on lung, skin, and digestive system cancers. As we confront this pressing environmental and public health challenge, a deeper understanding of the microplastic-cancer relationship is crucial to safeguarding the well-being of present and future generations. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.