Browsing by Author "Ashutosh Dwivedi"

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Green synthesis, characterization and in vitro biological studies of quercetin complexes with Zn (II) acetate and N^N Moiety
(Research Journal of Pharmacy and Technology, 2021) Tanu Srivastava; S.K. Mishra; O.P. Tiwari; Kavindra Nath Tiwari; Pradeep Kumar; Jitendra Kumar; Amit Kumar Singh; Angaraj Singh; Ashutosh Dwivedi
Green synthesis of two coordination complexes of zinc acetate with N^N moiety on quercetin, which is a flavonoid is carried out. The complexes were obtained in high yields (> 97%) by grinding methods without the involvement of any solvent. Neither catalyst nor any additives were needed to perform the reactions. It was characterized by FT-IR, UV-Vis, NMR, HRMS, and elemental analysis. Antioxidant activity was done through the DPPH method which was compared with ascorbic acid and ligand (Quercetin). The study reveals that Complex 1 (IC50 163.093µg/ml) has significant free radical scavenging activity as compared to complex 2 (IC50 258.683µg/ml). Biological activity was performed against microbes (E. coli and S. aureus). MIC value of complex 1 (15.50µg/ml E. coli, 7.18µg/ml S. aureus) was found more significant as compared to complex 2 (22.51µg/ml E. coli, 18.62µg/ml S. aureus) and quercetin. © RJPT All right reserved.