Browsing by Author "Asya Ozkizilcik"

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Retraction Note to: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease (Molecular Neurobiology, (2018), 55, 1, (300-311), 10.1007/s12035-017-0742-9)
(Springer, 2025) Hari Shanker Sharma; Dafin Fior Mureşanu; José Vicente Lafuente; Ranjana Saksena Patnaik; Zhengrong Ryan Tian; Asya Ozkizilcik; Rudy J. Castellani; Herbert Mössler; Aruna Sharma
The Editor-in-Chief has retracted this article because of concerns regarding the figures presented in this work. These concerns call into question the article's overall scientific soundness. An investigation conducted after its publication discovered the following issues: The bottom left corner of Panel c of Fig. 1 appears to overlap with a portion of the top right corner of Panel d of the same figure; The top half of Panel a of Fig. 2 appears to overlap with the bottom half of Panel b of the same figure; The top half of Panel b of Fig. 2 appears to overlap with the bottom half of Panel c of the same Figure; The top half of Panel c of Fig. 2 appears to overlap with the bottom half of Panel f of the same figure. The bottom left corner of Panel c of Fig. 1 appears to overlap with a portion of the top right corner of Panel d of the same figure; The top half of Panel a of Fig. 2 appears to overlap with the bottom half of Panel b of the same figure; The top half of Panel b of Fig. 2 appears to overlap with the bottom half of Panel c of the same Figure; The top half of Panel c of Fig. 2 appears to overlap with the bottom half of Panel f of the same figure. These panels represent different types of tissue or tissues taken from animals which underwent different treatments. The Editor-in-Chief therefore no longer has confidence in the integrity of the research presented in this article. Hari Shanker Sharma and Aruna Sharma disagree with this retraction. Dafin Fior Muresanu, José Vicente Lafuente, Ranjana Patnaik, Z. Ryan Tian, Asya Ozkizilcik, and Herbert Mössler have not replied to correspondence from the Publisher. Rudy J. Castellani, who is listed as a co-author of this article, has stated that he did not participate in the research reported therein and that his name and affiliation were added to the author list without his consent. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Retraction to: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease (Molecular Neurobiology, (2018), 55, 1, (300-311), 10.1007/s12035-017-0742-9)
(Springer, 2024) Hari Shanker Sharma; Dafin Fior Muresanu; José Vicente Lafuente; Ranjana Patnaik; Z. Ryan Tian; Asya Ozkizilcik; Rudy J. Castellani; Herbert Mössler; Aruna Sharma
The Editor-in-Chief has retracted this article because of concerns regarding the figures presented in this work. These concerns call into question the article's overall scientific soundness. An investigation conducted after its publication discovered the following issues: The bottom left corner of Panel c of Fig. 1 appears to overlap with a portion of the top right corner of Panel d of the same figure; The top half of Panel a of Fig. 2 appears to overlap with the bottom half of Panel b of the same figure; The top half of Panel b of Fig. 2 appears to overlap with the bottom half of Panel c of the same Figure; The top half of Panel c of Fig. 2 appears to overlap with the bottom half of Panel f of the same figure. The bottom left corner of Panel c of Fig. 1 appears to overlap with a portion of the top right corner of Panel d of the same figure; The top half of Panel a of Fig. 2 appears to overlap with the bottom half of Panel b of the same figure; The top half of Panel b of Fig. 2 appears to overlap with the bottom half of Panel c of the same Figure; The top half of Panel c of Fig. 2 appears to overlap with the bottom half of Panel f of the same figure. These panels represent different types of tissue or tissues taken from animals which underwent different treatments. The Editor-in-Chief therefore no longer has confidence in the integrity of the research presented in this article. Hari Shanker Sharma and Aruna Sharma disagree with this retraction. Dafin Fior Muresanu, José Vicente Lafuente, Ranjana Patnaik, Z. Ryan Tian, Asya Ozkizilcik, and Herbert Mössler have not replied to correspondence from the Publisher. Rudy J. Castellani, who is listed as a co-author of this article, has stated that he did not participate in the research reported therein and that his name and affiliation were added to the author list without his consent. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies
(Elsevier B.V., 2021) Hari Shanker Sharma; Dafin F. Muresanu; Asya Ozkizilcik; Seaab Sahib; Z. Ryan Tian; José Vicente Lafuente; Rudy J. Castellani; Ala Nozari; Lianyuan Feng; Anca D. Buzoianu; Preeti K. Menon; Ranjana Patnaik; Lars Wiklund; Aruna Sharma
Military personnel are often exposed to high environmental heat associated with industrial or ambient abundance of nanoparticles (NPs) affecting brain function. We have shown that engineered metal NPs Ag and Cu exacerbate hyperthermia induced brain pathology. Thus, exploration of novel drug therapy is needed for effective neuroprotection in heat stroke intoxicated with NPs. In this investigation neuroprotective effects of cerebrolysin, a balanced composition of several neurotrophic factors and active peptides fragments exhibiting powerful antioxidant and anti-ischemic effects was examined in heat stroke after NPs intoxication. In addition, its efficacy is compared to currently used drugs in post-stroke therapies in clinics. Thus, levertiracetam, pregabalin, topiramat and valproate were compared in standard doses with cerebrolysin in heat stroke intoxicated with Cu or Ag NPs (50–60 nm, 50 mg/kg, i.p./day for 7 days). Rats were subjected to 4 h heat stress (HS) in a biological oxygen demand incubator at 38 °C (Relative Humidity 45–47%; Wind velocity 22.4–25.6 cm/s) that resulted in profound increase in oxidants Luminol, Lucigenin, Malondialdehyde and Myeloperoxidase, and a marked decrease in antioxidant Glutathione. At this time severe reductions in the cerebral blood flow (CBF) was seen together with increased blood-brain barrier (BBB) breakdown and brain edema formation. These pathophysiological responses were exacerbated in NPs treated heat-stressed animals. Pretreatment with cerebrolysin (2.5 mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group. The other drugs were least effective on brain pathology following heat stroke. However, in NPs treated heat stressed animals 5 mL/kg conventional cerebrolysin and 2.5 mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF. Interestingly, the other drugs even in higher doses used are unable to alter brain pathologies in NPs and heat stress. These observations are the first to demonstrate that cerebrolysin is the most superior antioxidant and anti-ischemic drug in NPs exposed heat stroke, not reported earlier. © 2021 Elsevier B.V.