Browsing by Author "Atul Kabra"

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Fruit and Vegetable Peel-Enriched Functional Foods: Potential Avenues and Health Perspectives
(Hindawi Limited, 2022) Kanchan Bhardwaj; Agnieszka Najda; Ruchi Sharma; Renata Nurzyńska-Wierdak; Daljeet Singh Dhanjal; Rohit Sharma; Sivakumar Manickam; Atul Kabra; Kamil Kuča; Prerna Bhardwaj
Fresh fruit and vegetables are highly utilized commodities by health-conscious consumers and represent a prominent segment in the functional and nutritional food sector. However, food processing is causing significant loss of nutritional components, and the generation of waste is creating serious economic and environmental problems. Fruit and vegetables encompass husk, peels, pods, pomace, seeds, and stems, which are usually discarded, despite being known to contain potentially beneficial compounds, such as carotenoids, dietary fibers, enzymes, and polyphenols. The emerging interest in the food industry in the nutritional and biofunctional constituents of polyphenols has prompted the utilization of fruit and vegetable waste for developing enriched and functional foods, with applications in the pharmaceutical industry. Moreover, the utilization of waste for developing diverse and crucial bioactive commodities is a fundamental step in sustainable development. Furthermore, it provides evidence regarding the applicability of fruit and vegetable waste in different food formulations especially bakery, jam, and meat based products. © 2022 Kanchan Bhardwaj et al.
Naturally-occurring Bioactive Molecules with Anti-Parkinson Disease Potential
(Bentham Science Publishers, 2022) Atul Kabra; Kamal Uddin; Rohit Sharma; Ruchika Kabra; Raffaele Capasso; Caridad Ivette Fernandez Verdecia; Christophe Hano; Natália Cruz-Martins; Uttam Singh Baghel
Parkinson's disease (PD) is a complex limiting neurodegenerative disorder, with a rising incidence. Current therapeutic options for PD have multiple limitations, and naturally occurring biomolecules, often known as phytochemicals, with potent neuroprotective activities, have been searched to meet the need. Thus, this chapter encompasses in-depth information on reported anti-PD activities of medicinal plants in light of available pre-clinical and clinical studies and shares the mechanisms of action proposed in fighting PD. Published information from PubMed, Scopus, Science Direct, Springer, Google Scholar, and other allied databases was analyzed. There is rising interest among researchers in investigating medicinal plants and their isolated compounds for their anti-PD efficacy. Scattered information about the anti-PD potential of plants and bioactive compounds is reported in the scientific domain. A total of 92 medicinal plants belonging to 63 families, exhibiting anti-PD activity were discussed. Botanical species have revealed an extreme potential, encouraging future examination. Data discussed here can be used for further research and clinical purposes. © 2022, Bentham Books imprint. All Rights Reserved.
Neuroprotective potential of Myrica esulenta in Haloperidol induced Parkinson's disease
(Elsevier B.V., 2020) Atul Kabra; Uttam Singh Baghel; Christophe Hano; Natalia Martins; Mohammad Khalid; Rohit Sharma
Background: Myrica esculenta is a notable therapeutic plant widely utilized in Indian system of medicine. Ayurvedic literature reported fruit and bark of this plant is used in gulma, jvara, arsa, grahani, pandu roga, hrillasa, mukha roga, kasa, svasa, agnimandhya, aruchi, meha, and kantharoga. Objective: The present study aimed to investigate the neuroprotective potential of “Himalayan Bayberry” (Myrica esculenta Buch.-Ham. ex D. Don) leaves methanol extract in Parkinson's disease induced by haloperidol. Materials and methods: The present investigation was completed in wistar rats, in which Parkinson's disease (PD) was induced with haloperidol 1 mg/kg, intraperitoneally. The rats were randomly divided into six gatherings and the test animals received the methanolic extract of M. esculenta (MEME) at a dose of 50, 100 and 200 mg/kg, orally for one week. Various behavioural, biochemical and histopathological parameters were estimated in haloperidol exposed rats. Results: MEME demonstrated significant and dose-dependent increment in behavioural activity and improved muscle coordination. The significant diminution in malonaldehyde level while improved the level of antioxidant enzymes like catalase, superoxide dismutase and reduced glutathione in extract treated group were observed as compared to the control group. Histopathological changes revealed MEME significantly reduced haloperidol-induced damage in the substantia nigra and there was very little neuronal atrophy. Conclusion: The outcomes showed the defensive role of M. esculenta against PD. The mechanism of protection may be due to an escalation of cellular antioxidants. © 2020 The Authors
Phytochemical profiling and biological activities of Diplazium esculentum (Retz.) Sw.: An edible vegetable fern
(Walter de Gruyter GmbH, 2023) Kirti Raina; Alisha Chaudhary; Purnima Sharma; Rohit Sharma; Kanchan Bhardwaj; Pardeep Kumar; Atul Kabra; Sunil Thakur; Ashun Chaudhary; Mamta Prajapati; Pradeep Kumar Prajapati; Rajeev K. Singla
Objectives: Diplazium esculentum (Retz.) Sw. is an edible vegetable fern of the Himalayan region with high nutritional and therapeutic value owing to its richness in various secondary metabolites and both macro and micronutrients. Content: This updated review discusses the general traditional use, ethnopharmacology, phytochemistry, nutritional value, pharmacology, and toxicity concerns of D. esculentum. Summary: The plant parts, viz. rhizomes, shoots, fronds and leaves, have immense ethnomedicinal importance, being traditionally used to cure several health disorders. Among other pharmacological effects, this botanical reveals excellent anti-inflammatory, analgesic, antifungal, antibacterial, antioxidant, anti-leishmanial, antioxidant, anaphylactic, antipyretic, anthelmintic and hepatoprotective activities, directly attributed to the presence of many secondary metabolites. From a pharmacological point of view, the excellent antioxidant potential of D. esculentum suggests its promising use for nutraceutical or functional food formulation purposes. Outlook: Considering the evidences on popular ethnomedicinal uses of D. esculentum as an edible vegetable, its immense bio-potential, and multiple pharmacological roles, there is a huge need to evaluate its therapeutic applications in light of standard clinical trials. © 2023 Walter de Gruyter GmbH, Berlin/Boston.
Recent advancements in photodynamic therapy and cancer biosensor using natural products
(Elsevier B.V., 2023) Akshansh Sharma; Sounok Sengupta; Lokender Kumar; Tarun Upadhyay; Atul Kabra; H. Lalhlenmawia; Deepak Kumar; Jay Singh
Cancer is one of the utmost lethal diseases that disrupts metabolic pathways in a biological system where human cells acquire the transition from normal growth stages to neoplastic growth states, leading to the development of malignant tumours. It continues to be a problem for the world health, requiring constant innovation in prevention, early detection and treatment methods. Cancer biosensors have become potent diagnostic tools that allow for the quick and accurate identification of cancer biomarkers. Additionally, natural products have drawn interest owing to their potential for use in cancer therapy and cancer diagnosis. This review aims to highlight the applicability of plant-based, marine-based and microbe-based biosensors. Combining these biosensors with Photodynamic Therapy (PDT), a non-invasive therapeutic approach, offers a lot of potential for targeted cancer therapy. This review also elaborates on the value of natural materials as sources of photosensitizers for photodynamic therapy and demonstrates their advantages such as, raised selectivity, fewer adverse reactions, and better therapeutic results. Moreover, the combination of photodynamic therapy using natural products with cancer biosensors provides a cutting-edge strategy in oncology. The care of cancer may be revolutionised as research advances by addressing problems and improving these methods, opening the door for more efficient, patient-specific interventions. © 2023