Browsing by Author "B. Dube"

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Acquired pure red cell aplasia: is chloroquine a culprit?
(1993) V.P. Singh; S. Sunder; K. Kumar; B. Dube; R.K. Dube
[No abstract available]
Acute megaloblastic reaction in hereditary spherocytosis.
(1993) J. Shukla; O.P. Mishra; G.P. Katiyar; B. Dube
[No abstract available]
Alterations in blood fibrinolysis in occlusive stroke
(1978) R.K. Dube; P.K. Saha; B. Dube; B.C. Katiyar; P.V. Rao
Plasminogen activator content of plasma in 35 patients of occlusive stroke, as tested by fibrin plate lysis technique, was noted to be mildly depressed during the first week stroke (T1 stage) and elevated during the next few weeks (T2 stage), but the changes did not attain statistical significance, in comparison with controls. However, T1 lysis was significantly reduced as compared to T2 lysis. Plasma fibrinogen levels were significantly elevated during T1 as well as T2 stages. The alteration in fibrinolysis appears to be mild in nature and of limited importance per se, in the pathogenesis of stroke. In conjunction with other coagulation changes, it may be regarded as a contributory factor towards the 'hypercoagulable state'.
Anaemia of pregnancy in Northern India. Nature and therapeutic follow-up
(1977) S. Khanna; B. Dube; S. Kumar
Investigations on 114 anemic pregnant women revealed that megaloblastosis occurred in more than half. A therapeutic follow up approach clearly indicated that vitamin B12 deficiency was fairly common in such patients; the need of iron supplementation in many of them to achieve complete remission emphasized the poor status of iron stores. All patients with normoblastic marrow achieved full remission with iron therapy alone. The deficiency of hematinic factors appears to be largely due to poor nutrition.
Antithrombin III activity in cerebrovascular accidents
(2003) V.P. Singh; M.K. Singh; V. Kumar; M.K. Sinha; R.C. Dwivedi; M. Rai; B. Dube
Cerebrovascular accidents are commonly due to occlusive or haemorrhagic lesions. The present prospective study was planned to find out role of antithrombin in possible etiopathological process, which might predispose an individual for stroke. Method: Biological activity of antithrombin III was done by the method as described by Innerfield et al (1976). Immunological estimation of an antithrombin III was done by single radial immunodiffusion by the technique of Mancini et al modified by Fahey and Mckelvey. Results: The biological and immunological activity of antithrombin III was measured in 98 patient of occlusive and 56 patients of haemorrhagic strokes. Significant depression in biological as well as immunological activity (p<0.001) was observed in occlusive stroke. In haemorrhagic stroke both, biological and immunological activity was increased. In follow up study, there was progressive normalization of both, biological as well as of immunological activity in both group. Conclusion: Decrease of antithrombin III in occlusive and increase in haemorrhagic stroke indicates that these changes have at least an additive role in the pathogenesis of stroke.
Antithrombin III in liver disorders.
(1991) S. Sundar; R.K. Mall; B. Dube; V.P. Singh
Biological and immunological antithrombin III was studied in 26 patients of viral hepatitis including 6 with encephalopathy, and in 11 patients with cirrhosis of liver. There was a significant reduction in both biological and immunological activity of antithrombin III in all the groups of liver disorders studied. There was a good correlation between biological and immunological activity of antithrombin III (P less than 0.05). Further, there was a significant inverse correlation between immunological activity of antithrombin III and SGOT/SGPT (P less than 0.01) as well as serum bilirubin (P less than 0.001), signifying the prognostic value of antithrombin III in hepatitis. Biological activity on the other hand did not show any relation with the hepatic enzymes or bilirubin elevation. The antithrombin III levels appeared to decline in direct proportion to the degree of hepatic necrosis, probably due to reduced synthesis.
Blood coagulation profile in patients with acute diffuse peritonitis
(1978) B. Dube; B.N.S. Bhatnagar; K.S. Rao
Coagulation studies conducted on 42 patients with acute peritonitis of varying etiology revealed statistically significant prolongation of kaolin cephalin clotting time, decrease of platelets and elevation of plasma fibrinogen and serum fibrinogen degradation products. The relationship of the coagulopathy to bacterial invasion of peritoneal cavity was indicated by the absence of significant change in KCCT, prothrombin time, and bleeding time in patients with sterile peritoneal fluid. The results suggest a process of insidious defibrination intricately superimposed on the hypercoagulable state in these patients.
BLOOD COAGULATION PROFlLE IN INDIAN PATIENTS WITH PRE‐ECLAMPSIA AND ECLAMPSIA
(1975) B. Dube; Sulekha Bhattacharya; Rama Kanta Dube
Twelve Indian patients with pre‐eclampsia, 15 with eclampsia and 15 with normal pregnancy in the third trimester were investigated. A systemic bleeding diathesis was encountered in two patients with eclampsia and in none with pre‐eclampsia; two patients with pre‐eclampsia, however, had excessive uterine haemorrhage. Coagulation studies showed statistically significant prolongation of thrombin time, elevation of serum fibrinogen degradation products (FDP) and hypofibrino‐ genaemia in patients with pre‐eclampsia as well as eclampsia. In patients with eclampsia, significant thrombocytopenia also occurred. Euglobulin lysis time showed no significant change in patients with pre‐eclampsia and eclampsia. There was no significant difference in the coagulation profile between patients with eclampsia and pre‐eclampsia, except for more hypofibrinogenaemia in the former. The laboratory findings suggest the occurrence of intravascular coagulation Copyright © 1975, Wiley Blackwell. All rights reserved
Blood coagulation studies in children with surface hemangiomas
(1975) B. Dube; P.N. Pillai; G.D. Singhal; N.N. Khanna
Thirty children with surface hemangiomas were investigated for any latent coagulopathy. Whole blood clotting time, kaolin cephalin clotting time, prothrombin time, thrombin time and platelet counts did not differ significantly from the control group values. The values of plasma fibrinogen, euglobulin lysis time and serum levels of fibrinogen degradation products remained within the normal ranges but their mean values were significantly different from those of healthy children. The findings may be attributed to a chronic incipient type of 'consumption coagulopathy' occurring locally in the hemangiomas.
BLOOD COAGULATION STUDIES IN PREGNANT PATIENTS WITH INFECTIVE HEPATITIS
(1977) B. Dube; Sulekha Bhattacharya; V.N. Sinha; L.K. Pandey; R.K. Dube
Coagulation studies were made on 22 pregnant women with acute infective hepatitis and on 15 normal control pregnant women in third trimester. Fourteen hapatitis patients had clinical evidence of liver failure and all of them had a haemorrhagic diathesis; none of the patients without liver failure showed clinical evidence of haemostatic defects. Coagulopathy was present in most patients, its severity being greater in those with hepatic failure. Significant alterations were observed in bleeding time, whole blood clotting time, prothrombin time, thrombin time, plasma fibrinogen and serum levels of fibrinogen degradation products. The last three disturbances were most frequent in patients with liver failure. Increased fibrinolysis and disseminated intravascular coagulation also appeared to play a contributory role, particularly in patients with hepatic failure. Copyright © 1977, Wiley Blackwell. All rights reserved
Blood coagulation studies in some wild Indian birds: Effect of different tissue thromboplastins
(1977) Nasreen Tahira; B. Dube; G.P. Agrawal
Brain and lung thromboplastins of various vertebrates were tested for their clotting activity with plasma samples from pigeons, kites, vultures and man. There was a class specificity in the action of thromboplastins and it was confirmed that this largely depended on factors VII and X. © 1977.
Blood fibrinolytic activity in cancer patients
(1976) B. Dube; M.S. Khanna; B.J. Kulkarni
Fibrinolytic activity was tested in 36 patients with malignancy, 10 patients with non malignant surgical conditions and 20 normal controls. Euglobulin lysis time was significantly shortened in cancer as well as in other surgical conditions. Thrombin time was prolonged in one third of the cancer but in none of the noncancer patients. Plasma fibrinogen was significantly elevated in both of these groups. It is suggested that increased fibrinolytic activity is a homeostatic response to the non specific 'hypercoagulable state' seen in malignant as well as in other surgical illnesses.
Blood fibrinolytic system in Rana tigrina
(1981) V.M. Srivastava; B. Dube; R.K. Dube; G.P. Agarwal; N. Ahmad
Fibrinolytic activity is well demonstrable in the blood of Rana tigrina. There occurs prompt lysis of diluted plasma; and the plasma euglobulin fraction shows lysis on both unheated and heated fibrin (human or bovine) plates, implying the presence of plasmin-like enzyme in this fraction. The fibrinolytic activity is remarkably inhibited by the erythrocyte-lysate and is moderately enhanced by leucocytes-thrombocytes. EACA suppresses the lysis of dilute cell-free plasma clots at concentration of 10-4M or more, possibly indicating the presence of plasminogen activator in the plasma. Activation of fibrinolysis by human urokinase and not by streptokinase, shows the probable presence of plasminogen and absence of proactivator.
Canine shock: Irreversibility and coagulopathy
(1979) B. Dube; M.K. Misra; D. Nayadamma
Canine shock was experimentally induced by 'superior mesenteric artery occlusion followed by release:' two hours of occlusion produced reversible shock while four hours of occlusion caused irreversible shock. In both situations, the animals showed coagulopathy but the magnitude of same was more severe in animals with irreversible shock. The nature of coagulation changes was suggestive of intravascular coagulation. Histological changes showed widespread intravascular fibrin thrombi in the liver and the kidney in animals with irreversible shock and only limited local intravascular coagulation in the subcapsular region of the liver in those with reversible shock. The importance of diffuse intravascular coagulation in the irreversibility of shock was also corroborated by the 'reversion' of shock by prior heparinization.
Changes in platelets of cancer patients
(1974) B. Dube; M.N. Khanna; B.J. Kulkarni
Out of 40 cancer patients significant thrombocytosis and thrombocytopenia was observed in 2. However, their mean platelet count did not differ significantly from that of normal controls. Platelet factor 3 (PF 3) activity was significantly poor in cancer patients as compared to normal controls and those with other surgical conditions. Bleeding time was prolonged in 7 cases and shortened in 3 instances. The platelet count and PF 3 activity did not show significant relationship with clinical bleeding diathesis, but bleeding time was significantly prolonged in 'bleeders'. It is suggested that the altered procoagulant platelet activity maintained a delicate counterbalancing force against the 'hypercoagulable state' in most of the cancer patients.
Comparative studies of blood coagulation in hibernating and non-hibernating frogs (Rana tigrina)
(1979) N. Ahmad; B. Dube; G.P. Agarwal; R.K. Dube
During hibernation in frogs (Rana tigrina) there occurs prologation of several clotting tests, viz, whole blood clotting time, plasma recalcification time, cephalin time and prothrombin time. The ambient body temperature of the frog during winter hibernation is low and the retarded blood clotting at lower temperature may play an important protective role against intravascular thrombosis. Shorter plasma recalcification time in low-spun plasma as compared to high-spun plasma indicated the presence of procoagulant activity in platelets/leucocytes of frogs.
Congenital factor XIII deficiency.
(1993) J. Shukla; B. Dube; R.K. Dube; B.K. Das; O.P. Mishra
[No abstract available]
Congenital haemorrhagic disorders in paediatric practice
(Springer India, 1974) S.M. Dubey; B. Dube; K.N. Agarwal
Clinical and diagnostic laboratory findings are described in all cases of haemophilia A and 2 cases of haemophilia B. Bleeding from the umbilical stump, an unusual feature, was noted in 2 cases of haemophilia A and one case of haemophilia B. In all the patients with haemophilia A, haemostasis was achieved by the transfusion of a single unit of fresh blood or plasma. The control of bleeding in haemophilia B was difficult and required many transfusions. © 1974 Dr. K C Chaudhuri Foundation.
Danazol in Indian haemophiliacs.
(1993) S. Sundar; G.S. Moorleedhur-Singh; B. Dube; V.P. Singh; K. Kumar
Danazol, 10 mg/kg/day (maximum 600 mg/day) was given in two divided doses for 14 days in 30 patients with haemophilia-A. Rise in factor-VIII level was observed in all the patients after one week of danazol therapy, irrespective of initial factor-VIII Levels. In haemophiliacs with less than 1% factor VIII level, rise was maximum (3-6 folds); mean factor-VIII level at 7th and 14th day of danazol therapy was 2.3 +/- 0.6% and 4.8 +/- 1.1%, respectively. Only marginal increase in factor-VIII was noted in haemophiliacs with initial factor-VII levels more than 3%. The raised level of factor-VIII persisted after stopping the therapy during the observation period of 2 more weeks, irrespective of initial levels. No adverse effect was observed during or after.
Down's syndrome with acute myeloid leukemia.
(1994) V.P. Singh; S. Sundar; K. Kumar; J. Shukla; B. Dube
[No abstract available]