Browsing by Author "B. Kumar"

Now showing 1 - 19 of 19

A microculture technique for isolating live Leishmania parasites from peripheral blood of visceral leishmaniasis patients
(2007) M. Hide; R. Singh; B. Kumar; A.L. Bañuls; S. Sundar
Current procedures for diagnosing Leishmania parasites from patients involve invasive and dangerous tissue aspiration. We have developed a non-invasive and highly sensitive microculture method that can isolate parasites from the buffy coat of the patient's peripheral blood. The parasites were cultured in 96-well culture plates. Nineteen parasitologically proven visceral leishmaniasis (VL) patients were included in the study. Using this technique, we were able to isolate parasites from 16 (84%) samples. However, all 19 (100%) samples were positive on culture of splenic aspirates. We conclude that this technique is useful for the isolation and cryoconservation of parasites from patients' blood. This simple method could be tried as a first-instance alternative before other more sensitive procedures such as splenic aspirate; however, negative results should be confirmed by tests with higher sensitivity. © 2007 Elsevier B.V. All rights reserved.
A Pilot Study on Knowledge and Experience on use of Generic Medicines among Healthcare Professionals
(Research Journal of Pharmacy and Technology, 2022) Vinay Kumar Gupta; Amit Singh; Ajay K. Gupta; A. Trigunayat; B. Kumar
Those medicines which are having same efficacy as that of their branded and expensive counterparts are known as Generic medicines. Compare to branded medicines, generic medicines have similar route of administration, indication, side effects, strength. Contrary to lower price and affordability the generic medicines are not so popular among healthcare professionals. The objective of this study is to analyse, knowledge and experience on use of generic medicines among healthcare professionals. A pilot study was conducted at Institute of Medical Sciences (IMS) Banaras Hindu University Varanasi India. This was a questionnaire-based cross-sectional study. The participants were doctors, nurses, pharmacists and others (research scholars and PG students). Chi square test used to find out p value. The overall response rate was 84.61 percent (55/65). Among all participants 12.7 percent did not “heard about Pradhan Mantri Jan Aushadhi Pariyojana Kendra”. Among all participants only 40 percent were not aware about Pradhan Mantri Jan Aushadhi Pariyojana Kendra situated in their area. Among all participants 72.73% aware about safe generic medicines, while among participant groups 60% of participating doctors, all nursing and pharmacy professionals and 72% of others accepted that generic medicines are safe as like branded medicines. A variation observed in respect of knowledge, and experience on generic medicines among participants. 40% (percent) of participating doctors did not believe in generic medicines and opted that the generic medicines are not safe as like branded medicines. Therefore, need for more training/awareness programmes on generic medicine arises. Need for building trust among healthcare professionals on generic medicines required. © RJPT All right reserved.
A study of knowledge and traditional wisdom of makhana cultivation in bihar
(National Institute of Science Communication and Information Resources, 2021) A. Kumar; A.K. Singh; B. Kumar; S. Kumari
Makhana (Euryale ferox) is an aquatic crop from the family Nymphaeace and is commonly grown in stagnant water bodies like ponds, swamps and ditches with shallow water. Euryale is a self-pollinated plant, in which pollination takes place at the early stage of flower development. Bihar is the largest producer of makhana throughout the country with an area of approx 15,000 ha. In spite of several uses and immense market potential in India and abroad, makhana is still cultivated through traditional system, area of which is declining in recent years. Therefore, an attempt was made to understand traditional wisdom of makhana production practices with special reference to its post harvest management. For this purpose, 100 makhana growers were identified from Madhubani district of Bihar which occupies more than 30% of the total area and production. They were personally interviewed with the help of a structured schedule consisting of different components such as, suitable soils in terms of type, quality and its strength, the type, slope and depth of ponds of makhana, the preparation and management of pond for makhana cultivation, seeds with respect to source and quality, fertilizer and disease management, harvesting process of makhana with respect to its the time and process of maturity along with the grading and marketing of makhana. The results indicated that makhana production practices are primarily governed with the traditional knowledge system which the growers obtained through their forefathers. © 2021, National Institute of Science Communication and Information Resources. All rights reserved.
Carbon, oxygen and strontium isotope geochemistry of Proterozoic carbonate rocks of the Vindhyan Basin, central India
(2002) B. Kumar; S. Das Sharma; B. Sreenivas; A.M. Dayal; M.N. Rao; N. Dubey; B.R. Chawla
Carbon, oxygen and strontium isotope compositions of carbonate rocks of the Proterozoic Vindhyan Supergroup, central India suggest that they can be correlated with the isotope evolution curves of marine carbonates during the latter Proterozoic. The carbonate rocks of the Lower Vindhyan Supergroup from eastern Son Valley and central Vindhyan sections show δ13C values of ∼ 0% (V-PDB) and those from Rajasthan section are enriched up to + 2.8‰. In contrast, the carbonate rocks of the Upper Vindhyan succession record both positive and negative shifts in δ13C compositions. In the central Vindhyan section, the carbonates exhibit positive δ13C values up to + 5.7‰ and those from Rajasthan show negative values down to -5.2‰. The δ18O values of most of the carbonate rocks from the Vindhyan Supergroup show a narrow range between -10 and -5‰ (V-PDB) and are similar to the 'best preserved' 18O compositions of the Proterozoic carbonate rocks. In the central Vindhyan and eastern Son Valley sections, carbonates from the Lower Vindhyan exhibit best-preserved 87Sr/86Sr compositions of 0.7059 ± 6, which are lower compared to those from Rajasthan (0.7068 ± 4). The carbonates with positive δ13C values from Upper Vindhyan are characterized by lower 87Sr/86Sr values (0.7068 ± 2) than those with negative δ13C values (0.7082 ± 6). A comparison of C and Sr isotope data of carbonate rocks of the Vindhyan Supergroup with isotope evolution curves of the latter Proterozoic along with available geochronological data suggest that the Lower Vindhyan sediments were deposited during the Mesoproterozoic Eon and those from the Upper Vindhyan represent a Neoproterozoic interval of deposition. © 2002 Elsevier Science B.V. All rights reserved.
Cytomorphological effects of gamma rays on Capsicum annuum
(1997) S.B. Agrawal; B. Kumar; B.R. Chaudhary
Dry seeds of Capsicum annuum var. Saini were irradiated with gamma rays (100-400 Gy) and the radioresponse was studied on the basis of the survival of seedlings, growth performances, yield, pollen sterility and cytological abnormalities. The abnormal chromosomes displayed stickiness, clumping, altered configurations, breakages, laggards, bridges, unusual separation/orientation and abnormal microspores, and their frequencies were directly correlated with the 60Co dose of gamma rays. Pollen sterility increased linearly with increasing doses of gamma rays. The yield was measured in terms of the number of fruits per plant and it decreased with higher doses of mutagen. None of the doses was beneficial for the variety of Capsicum under investigation.
Effect of hydrolysed Trifolium repens L. extract on menopause induced obesity and depressive symptoms: an in-vitro and in-silico approach
(Taylor and Francis Ltd., 2025) Poonam Rawat; B. Kumar; Ankita N. Misra; Satyendra Pratap Singh; Surya Pratap Singh; Sharad Kumar Srivastava
This study aimed to evaluate acid-hydrolysis effects on phytoestrogen content and the efficacy of phytoestrogen-rich extract in alleviating post-menopausal symptoms (PMS). Bioactive phytoestrogens were quantified using HPTLC, and unhydrolyzed and hydrolysed extracts were assessed for oestrogenic, anti-proliferative, MAO-A inhibition, ROS quenching, and PL inhibition potential through in-vitro models. In-silico analysis of quantified phytoestrogens against PMS-related proteins was conducted. Hydrolysis increased phytoestrogen content significantly, particularly biochanin-A (56.48-fold), daidzein (22.2-fold), genistein (10.77-fold), and formononetin (5.26-fold). The hydrolysed extract demonstrated improved efficacy in in-vitro models, including reduced IC50 in oestrogenic activity, decreased cell proliferation, increased MAO-A inhibition, and decreased IC50 for lipase. High binding energies of phytoestrogens against ERβ, MAO-A, and PL supported their potential in managing post-menopausal symptoms. The study scientifically validated T. repens for women’s health at menopause, highlighting acid-hydrolysis for enhancing therapeutic activity. T. repens could be explored commercially as an alternative to T. pratense. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
Evaluation of PCR for diagnosis of Indian kala-azar and assessment of cure
(2005) R. Maurya; R.K. Singh; B. Kumar; P. Salotra; M. Rai; S. Sundar
This study was done to evaluate PCR with Ld1 primers for the diagnosis of Indian visceral leishmaniasis (VL) and to assess its role in prediction of the disease outcome. The PCR assay was performed with DNA isolated from the peripheral blood of parasitologically confirmed cases of VL before the initiation of treatment, just after the end of treatment, and at 3 and 6 months of follow-up. The pretreatment PCR result was positive for 100 of 101 patients (sensitivity, 99%; confidence interval [CI], 94 to 100%). None of the 150 negative controls tested were PCR positive (specificity, 100%; CI, 96.8 to 100%). Of 60 patients who were treated at our center, 51 (85%; CI, 73 to 93%) became negative immediately after treatment and continued to be negative at 3 and 6 months of follow-up. At the 3-month follow-up, two of the remaining nine patients were PCR positive, making 58 (96.7%; CI, 87 to 100%) patients PCR negative. At the 6-month follow-up, all patients became PCR negative. One patient who was PCR negative immediately after the end of treatment relapsed 11 months later. This limited prospective study with VL patients suggests that the PCR assay is a highly sensitive and specific (99% and 100%, respectively) tool for the diagnosis of VL. In the majority of patients, it can identify a successful disease outcome; however, its translation into the field setting remains a major challenge.
Evaluation of retinoic acid in acne vulgaris
(1976) G. Singh; B. Kumar
[No abstract available]
In-vitro cytotoxicity evaluation of surface design luminescent lanthanide core/shell nanocrystals
(Elsevier B.V., 2020) Anees A. Ansari; Shahanavaj Khan; Ali Aldalbahi; Abdul K. Parchur; B. Kumar; Ashok Kumar; Mohammad Raish; S.B. Rai
Lanthanide nanocrystals (NCs) are the most promising luminescent materials for bioapplications, but their use is hindered by difficulties in obtaining biocompatible and photoluminescence lanthanide NCs. To solve this problem, a simple and versatile strategy was developed for improving the luminescence efficiency with the hydrophilicity of the lanthanide NCs. In this study, the effects of shell formation on structural, morphological, and optical properties (optical absorption, band-gap energy, excitation, emission, and luminescent decay time) were evaluated. To improve the luminescence efficiency and aqueous dispersion, luminescent core-NCs were encapsulated with inert NaGdF4 and amorphous silica layers. These surface coating layers significantly improved the luminescence efficiency and dispersion of the core/shell NCs in which the silica surface provides a negatively charged surface to the NCs at physiological pH. Optical properties of these NCs strongly depend on the external change of NCs, demonstrating the impact of coating in improving the luminescence efficiency. The outcomes can be ascribed to the development of surface chemical bonds between core/shell and noncrystalline SiO2 shell via Gd[sbnd]O[sbnd]Si bridges, activating the ‘dormant’ Ce3+ and Tb3+ ions on the surface of NCs. An intensive emission and good hydrophilic property from the active functional groups in solutions show a great potential for applications such as multi-analyte fluorescent biolabeling, optical biosensing, staining, display, and other optical technologies. The core/shell/SiO2 NCs showed higher nontoxicity and biocompatibility with respect to the core NCs because of biocompatible silica surface modification, facilitating entry into the living cells. Therefore, this developed synthesis approach might advance the field of biomolecule-based nanotechnology in near future. © 2017 King Saud University
Influence of Shell Formation on Morphological Structure, Optical and Emission Intensity on Aqueous Dispersible NaYF4:Ce/Tb Nanoparticles
(Springer New York LLC, 2016) Anees A. Ansari; A.K. Parchur; B. Kumar; S.B. Rai
A highly water-dispersible NaYF4:Ce/Tb (core), NaYF4:Ce/Tb@NaYF4(core/shell) and NaYF4:Ce/Tb@NaYF4@SiO2 (core/shell/SiO2) nanoparticles (NPs) were synthesized via a general synthesis approach. The growth of an inert NaYF4 and silica shell (~14 nm) around the core-NPs resulted in an increase of the average size of the nanopaticles as well as broadening of their size distribution. The optical band-gap energy slightly decreases after shell formation due to the increase the crystalline size. To optimize the influence of shell formation a comparative analysis of photoluminescence properties (excitation, emission, and luminescence decay time) of the core, core/shell, and core/shell/SiO2 NPs were measured. The emission intensity was significantly enhanced after inert shell formation around the surface of the core NPs. The Commission International de l’Eclairage chromaticity coordinates of the emission spectrum of core, core/shell, core/shell/SiO2 NPs lie closest to the standard green color emission at 545 nm. By quantitative spectroscopic measurements of surface-modified core-NPs, it was suggested that encapsulation with inert and silica layers was found to be effective in retaining both luminescence intensity and dispersibility in aqueous environment. Considering the high aqueous dispersion and enhanced luminescence efficiency of the core-NPs make them an ideal luminescent material for luminescence bioimaging and optical biosensors. © 2016, Springer Science+Business Media New York.
Lathyrism: Has the scenario changed in 2013?
(2014) V.N. Mishra; C.B. Tripathi; A. Kumar; V. Nandmer; A.Z. Ansari; B. Kumar; R.N. Chaurasia; D. Joshi
Lathyrism is now rarely seen as a clinical disease in general, medical or neurology outpatient departments, throughout the world. Eating patterns of seeds of Lathyrus sativus are still prevalent focal points in parts of the world. Question arises, why are we not seeing cases of lathyrism? Is it that the disease has changed its profile, with the changing socioeconomic status of the poor or underdeveloped or moderately developed countries? Is it that the seeds of lathyrus are less toxic now? Is it that the body defence against toxins of lathyrus has genetically modified? To find out answers to these interesting questions, an extensive questionnaire-based sampling was done among 1000 subjects from northern India to identify the human behaviour regarding the knowledge, attitude, and practices (KAPs) for L. sativus. Four clinically suspected cases of Lathyrism were also fully worked up. It was concluded that many areas of India are still being fed with lathyrus seeds, but not many cases have appeared. Many questions have to be answered, as to what has reduced the incidence of lathyrism. © W. S. Maney & Son Ltd 2014.
Miconazole in Pityriasis versicolor
(1975) G. Singh; B. Kumar
Miconazole 2% cream was tried in 26 patients with Pityriasis versicolor. The cream was rubbed on twice a day by the patient with the assistance of an attendant. Scrapings from the lesions were examined for fungus at the beginning and at the end of each application. In nearly 1/3rd of patients scrapings were negative at the end of 7 weeks' treatment. All but one patient became mycologically negative after 10 weeks. Return to normal color started after 3 to 4 weeks of start of treatment and became completely normal after 8 to 16 weeks. No untoward effects were seen and the cream was extremely acceptable.
'Needs' in patients of neurodermatitis circumscripta (lichen simplex chronicus)
(1980) B. Kumar; G. Singh; O.N. Srivastava; A.N. Jaiswal
[No abstract available]
Neuroprotective potential of Cucurbita maxima Duchesne ex Poir, Caeselpenia bunduc (L.) Roxb and Bombax ceiba Linn extracts
(Elsevier B.V., 2019) S. Sinha; B. Kumar; S. Luqman; D.K. Singh
Plant derived molecules are gaining importance as an alternative to synthetic drugs for the treatment of cognitive and related disorders. Modulation of cholinesterases, monoamine oxidases and sodium–potassium ATPase activities in brain through phyto-molecules has been found effective in the treatment and management of cognitive disorders. Considering the pleiotropic action of plant secondary metabolites, the present investigation was undertaken to explore neuroprotective activity of the ethanolic and hexane extracts from Cucurbita maxima Duchesne ex Poir (seeds), Caeselpenia bunduc (L.) Roxb (seeds) and Bombax ceiba Linn (flowers). To investigate the neuroprotective activity of these plant extracts, cholinesterases (acetylcholinesterase and butyrylcholinesterase), monoamine oxidase (MAO) and Na+/K+ ATPase activities were estimated. To test if chosen plant extracts have also effect on oxidative stress lipid peroxidation and metal chelating ability were determined in mice brain homogenate. In this investigation the ethanolic and hexane extracts from these plants were able to inhibit the acetylcholinesterase and butyrylcholinesterase (43.32–69.94%), which was comparable to standard drug, donepezil at the concentration of 50 μg/ml. The chromatographic (HPTLC) estimation revealed the maximum presence of quercetin in C. maxima whereas p-coumaric acid and gallic acid were found as major constituents in B. ceiba. In conclusion, the findings of current study provide evidence for the selected plant extracts with potent cholinesterase activity which can be taken as lead for further mechanistic study and also for development of plant based formulation after pre-clinical evaluation. © 2018 South African Association of Botanists
Observations of unusual Whistlers during Daytime at Jammu
(2008) K.K. Singh; R.P. Patel; J. Singh; B. Kumar; A.K. Singh; R.P. Singh; B.L. Koul; Lalmani
In this paper, we report observations of unusual whistlers recorded at Jammu (geomag. lat. = 22°26′N: L = 1.17), India on March 8, 1999 during the daytime. They are interpreted as one-hop ducted whistlers having propagated along higher L-values in closely spaced narrow ducts from the opposite hemispheres. After leakage from the duct, the waves might have propagated in the earth-ionosphere waveguide towards the equator in surface mode. Tentative explanation of the dynamic spectra of these events is briefly presented. © Printed in India.
Occurrence and Characteristics of Rhizobiophages in Pigeonpea Fields
(1998) B. Dhar; B. Kumar
Bacteriophages active against Rhizobium spp. nodulating pigeonpea were detected in soils of pigeon pea grown fields of Varanasi and neighbouring districts. Phages infective on 3 cowpea Rhizobium strains (IHP100, IHP195 and CB756) and 6 local pigeonpea Rhizobium strains (A003, A012, A024, A039, A050 and A059) were isolated. Distribution of phages in rhizosphere soil were different on indicator strains and had no relationship with soil pH. The field with pigeonpea after wheat contained phages infective on more strains than fields with pigeonpea after pigeonpea. Phages were also found in nodule exudates and maximum titre was 3.2 × 104 particles g-1 nodule mass. Host range, lytic activity, plaque characteristics and thermal stability of twelve phage isolates were studied. Five phages appeared to be more thermal resistant than others. EM examination of a thermal resistant phage (RT4) revealed that it had a hexagonal head (62 nm wide) and a short tail (60 × 20 nm).
Serological diagnosis of Indian visceral leishmaniasis: direct agglutination test versus rK39 strip test
(2006) S. Sundar; R.K. Singh; R. Maurya; B. Kumar; A. Chhabra; V. Singh; M. Rai
We evaluated the direct agglutination test (DAT), using freeze-dried (FD) and aqueous (AQ) antigen, and the rK39 immunochromatographic strip test in the diagnosis of Indian visceral leishmaniasis (VL). Sera from 508 subjects (150 parasitologically confirmed patients with VL, 100 and 153 healthy controls drawn from non-endemic and endemic regions, respectively, and 105 patients with other diseases presenting with fever and/or splenomegaly) were tested. The sensitivity of the tests were as follows: DAT (FD), 96% (95% CI 91-98); DAT (AQ), 97% (95% CI 93-99); rK39 strip test, 99% (95% CI 95-100). The specificity of DAT (FD), DAT (AQ) and rK39 strip tests were 85% (95% CI 81-88), 87% (95% CI 83-91) and 89% (95% CI 86-92), respectively. A significant correlation (high degree of agreement) was observed between all tests (κ > 0.80). We conclude that the sensitivity of FD antigen is comparable to that of AQ antigen. Similarly, the rK39 strip test is as sensitive as the DAT, but the strip test's greater convenience of use makes it a better tool for diagnosis of VL in peripheral areas of endemic regions. © 2005 Royal Society of Tropical Medicine and Hygiene.
Study of laser ablated copper nanoparticles in different liquids and their effect on optical properties of Tb3+ in PVA
(Scientific Publishers, 2015) B. Kumar; G. Kaur; S.B. Rai
Cu nanoparticles have been prepared in different liquids i.e. aqueous solution of sodium dodecyl sulfate, acetone and ethanol with the help of laser ablation from a bulk copper target using 1,064 nm from Nd:YAG laser. Transmission electron microscopy and UV–vis spectrometry have been employed for the analysis of size and optical properties of the nanoparticles, respectively. X-ray diffraction patterns confirm the formation of Cu nanoparticles. The nanoparticles exhibit hexagonal nature with average particle size of 15–25 and 20–30 nm in case of sodium dodecyl sulfate and acetone respectively, whereas they posses spherical symmetry with bigger particle size of 30–40 nm in ethanol. The surface plasmon resonance peak shifts from 587 to 613 nm in different solvents, which is partly related to the change in shape and size of the particles. Further, Cu nanoparticles in different solvents have been added to polymer with terbium (Tb3+) ions to seek into the optical properties of the samples. The photoluminescence of Tb3+ ions varies with Cu nanoparticles in different solvents in polyvinyl alcohol and the result has been further verified by lifetime analysis. © 2014, Indian Association for the Cultivation of Science.
Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection
(Oxford University Press, 2023) A. Mukherjee; G. Kumar; A. Turuk; A. Bhalla; T.C. Bingi; P. Bhardwaj; T.D. Baruah; S. Mukherjee; A. Talukdar; Y. Ray; M. John; J.R. Khambholja; A.H. Patel; S. Bhuniya; R. Joshi; G.R. Menon; D. Sahu; V.V. Rao; B. Bhargava; S. Panda; P. Mishra; Y. Panchal; L.K. Sharma; A. Agarwal; G.D. Puri; V. Suri; K. Singla; R. Mesipogu; V.S. Aedula; M.A. Mohiuddin; D. Kumar; S. Saurabh; S. Misra; P.K. Kannauje; A. Kumar; A. Shukla; A. Pal; S. Chakraborty; M. Dutta; T. Mondal; S. Chakravorty; B. Bhattacharjee; S.R. Paul; D. Majumder; S. Chatterjee; A. Abraham; D. Varghese; M. Thomas; N. Shah; M. Patel; S. Madan; A. Desai; M.L. Kala Yadhav; R. Madhumathi; G.S. Chetna; U.K. Ojha; R.R. Jha; A. Kumar; A. Pathak; A. Sharma; M. Purohit; L. Sarangi; M. Rath; A.D. Shah; L. Kumar; P. Patel; N. Dulhani; S. Dube; J. Shrivastava; A. Mittal; L. Patnaik; J.P. Sahoo; S. Sharma; V.K. Katyal; A. Katyal; N. Yadav; R. Upadhyay; S. Srivastava; A. Srivastava; N.N. Suthar; N.M. Shah; K. Rajvansh; H. Purohit; P.R. Mohapatra; M.K. Panigrahi; S. Saigal; A. Khurana; M. Panchal; M. Anderpa; D. Patel; V. Salgar; S. Algur; R. Choudhury; M. Rao; D. Nithya; B.K. Gupta; B. Kumar; J. Gupta; S. Bhandari; A. Agrawal; M. Shameem; N. Fatima; S. Pala; V. Nongpiur; S. Chatterji; S. Mukherjee; S.K. Shivnitwar; S. Tripathy; P. Lokhande; H. Dandu; A. Gupta; V. Kumar; N. Sharma; R. Vohra; A. Paliwal; M. Pavan Kumar; A. Bikshapathi Rao; N. Kikon; R. Kikon; K. Manohar; Y. Sathyanarayana Raju; A. Madharia; J. Chakravarty; M. Chaubey; R.K. Bandaru; M. Ali Mirza; S. Kataria; P. Sharma; S. Ghosh; A. Hazra
Objectives: This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC). Methods: NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined. Results: Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6–7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4–0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3–0.7)] were protected from in-hospital mortality. Conclusions: WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality. © The Author(s) 2022.