Browsing by Author "B.P. Jaiswal"

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Association of possible osteopetrosis with acute myeloid leukaemia in a child
(2013) Rajniti Prasad; B.P. Jaiswal; O.P. Mishra; Utpal Kant Singh
Osteopetrosis is a rare disease characterised by an increase in bone mass, skeletal malformations and bone marrow failure due to defective bone resorption. We report a 3-month-old male child presented with chest infections, failure to thrive and hepatosplenomegaly and diagnosed with osteopetrosis associated with acute myeloid leukaemia M3 type (AML-M3). The patient died on day 7 of admission due to respiratory failure. To our knowledge, this is the first case where both osteopetrosis and AML is diagnosed in a patient.
Current concept in the management of cerebral palsy
(Indian Medical Association, 2005) Rajniti Prasad; S.B.P. Singh; B.P. Jaiswal; Utpal Kant Singh
The authors have described, in depth, the current concept along with the management of cerebral palsy in the present article.
Miltefosine: An Oral Drug for Visceral Leishmaniasis
(The Indian Journal of Pediatrics, 2004) Rajniti Prasad; Ranjeet Kumar; B.P. Jaiswal; Utpal Kant Singh
Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmania in vitro and animal model. 1,2 Based on these experiences this drug was tried against human visceral leishmaniasis and found to be highly effective and achieved 97% and 94% cure in phase 2 and phase 3 trial in children.
Portal hypertension with visceral leishmaniasis
(2010) Rajniti Prasad; Utpal Kant Singh; O.P. Mishra; B.P. Jaiswal; Sunil Muthusami
We conducted this study to observe evidence of portal hypertension in children with visceral leishmaniasis (VL). Eighty-eight consecutive cases (50 male) of VL were subjected to ultrasonography. Those with evidence of portal hypertension also underwent upper gastrointestinal endoscopy and liver biopsy. Eight patients had portal hypertension as evidenced by dilated caliber of portal and splenic veins. Two patients had periportal, splenic and peripancreatic collaterals and one patient had cavernous transformation of portal vein. Out of eight patients, four patients had esophageal and gastric varices. Liver biopsy was done in four patients and revealed hepatic sinusoidal dilations without any evidence of fibrosis. Portal hypertension may be an independent manifestation of VL and remain undiagnosed unless a physician maintains a high index of suspicion.