Browsing by Author "Basanti Brar"

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An insight into nanomedicinal approaches to combat viral zoonoses
(Bentham Science Publishers, 2020) Prasad Minakshi; Mayukh Ghosh; Rajesh Kumar; Basanti Brar; Upendra P. Lambe; Somesh Banerjee; Koushlesh Ranjan; Balvinder Kumar; Parveen Goel; Yashpal S. Malik; Gaya Prasad
Background: Emerging viral zoonotic diseases are one of the major obstacles to secure the ‘‘One Health” concept under the current scenario. Current prophylactic, diagnostic and therapeutic approaches often associated with certain limitations and thus proved to be insufficient for customizing rapid and efficient combating strategy against the highly transmissible pathogenic infectious agents leading to the disastrous socio-economic outcome. Moreover, most of the viral zoonoses originate from the wildlife and poor knowledge about the global virome database renders it difficult to predict future outbreaks. Thus, alternative management strategy in terms of improved prophylactic vaccines and their delivery systems; rapid and efficient diagnostics and effective targeted therapeutics are the need of the hour. Methods: Structured literature search has been performed with specific keywords in bibliographic databases for the accumulation of information regarding current nanomedicine interventions along with standard books for basic virology inputs. Results: Multi-arrayed applications of nanomedicine have proved to be an effective alternative in all the aspects regarding the prevention, diagnosis, and control of zoonotic viral diseases. The current review is focused to outline the applications of nanomaterials as anti-viral vaccines or vaccine/drug delivery systems, diagnostics and directly acting therapeutic agents in combating the important zoonotic viral diseases in the recent scenario along with their potential benefits, challenges and prospects to design successful control strategies. Conclusion: This review provides significant introspection towards the multi-arrayed applications of nanomedicine to combat several important zoonotic viral diseases. © 2020 Bentham Science Publishers.
Application of polymeric nano-materials in management of inflammatory bowel disease
(Bentham Science Publishers, 2020) Prasad Minakshi; Rajesh Kumar; Mayukh Ghosh; Basanti Brar; Manju Barnela; Preeti Lakhani
Inflammatory Bowel Disease (IBD) is an umbrella term used to describe disorders that involve Crohn’s disease (CD), ulcerative colitis (UC) and pouchitis. The disease occurrence is more prevalent in the working group population which not only hampers the well being of an individual but also has nega-tive economical impact on society. The current drug regime used therapy is very costly owing to the chronic nature of the disease leading to several side effects. The condition gets more aggravated due to the lower concentration of drug at the desired site. Therefore, in the present scenario, a therapy is needed which can maximize efficacy, adhere to quality of life, minimize toxicity and doses, be helpful in maintaining and stimulating physical growth of mucosa with minimum disease complications. In this aspect, nanotechnology intervention is one promising field as it can act as a carrier to reduce toxicity, doses and frequency which in turn help in faster recovery. Moreover, nanomedicine and nanodiagnostic techniques will further open a new window for treatment in understanding pathogenesis along with better diagnosis which is poorly understood till now. Therefore the present review is more focused on recent advance-ments in IBD in the application of nanotechnology. © 2020 Bentham Science Publishers.
Exploring the Benefits of Nutrition of Little Millet: Unveiling the Effect of Processing Methods on Bioactive Properties
(John Wiley and Sons Inc, 2025) Annu Kumari; Pardeep Kumar Sadh; Ajay Kamboj; Babli Yadav; Anil Kumar; Subbarayan Sivakumar; Surekha; Baljeet Singh Saharan; Basanti Brar; Chhaya Goyal; Sanju Bala Dhull; Joginder Singh Duhan
Many terrible illnesses and disorders that modern man is dealing with today were not even known to ancient man. The only factor contributing to this disastrous situation is dietary habits. Thus, by avoiding and controlling them, replacing meals high in empty calories with nutrient-dense millets helps to alleviate the combined burden of contemporary metabolic illnesses and malnutrition. Because millet contains various nutrients, including proteins, minerals, lipids, vitamins, phytochemicals, dietary fiber, and complex carbohydrates, it positively impacts the immune system. Among whole millets, little millet (Panicum sumatrense) is one nutritious millet that contributes significantly to the supply of macro- and micronutrients and bioactive substances, including phenols, tannins, and phytates. However, some processing techniques, such as germination, fermentation, milling, and extrusion, impact little millet’s nutrients and bioactive chemicals by increasing or decreasing these phytochemicals. These nutrients and bioactive substances have physiological and beneficial properties related to health, such as weight management, antioxidants, antidiabetics, anticancer, antiobesity, and cardiovascular disease potential. It is also beneficial in preventing the risk of inflammatory, antirheumatic, and chronic disorders, as it possesses various value-added bioactive compounds such as kaempferol, luteolin, and apigenin. Little millet also contains some antinutrients such as tannins, oxalate, trypsin inhibitors, and phytate. These substances bind to the necessary nutrients, rendering them unavailable or limiting their utilization. The nutrients, processing effects, bioactive compounds, and health advantages of these compounds in little millet are all summarized in this paper. © © 2025 Annu Kumari et al. Journal of Food Biochemistry published by John Wiley & Sons Ltd.
Metal/metal oxide nanoparticles: Toxicity concerns associated with their physical state and remediation for biomedical applications
(Elsevier Inc., 2021) Anju Manuja; Balvinder Kumar; Rajesh Kumar; Dharvi Chhabra; Mayukh Ghosh; Mayank Manuja; Basanti Brar; Yash Pal; B.N. Tripathi; Minakshi Prasad
Metal/metal oxide nanoparticles show promise for various applications, including diagnosis, treatment, theranostics, sensors, cosmetics, etc. Their altered chemical, optical, magnetic, and structural properties have differential toxicity profiles. Depending upon their physical state, these NPs can also change their properties due to alteration in pH, interaction with proteins, lipids, blood cells, and genetic material. Metallic nanomaterials (comprised of a single metal element) tend to be relatively stable and do not readily undergo dissolution. Contrarily, metal oxide and metal alloy-based nanomaterials tend to exhibit a lower degree of stability and are more susceptible to dissolution and ion release when introduced to a biological milieu, leading to reactive oxygen species production and oxidative stress to cells. Since NPs have considerable mobility in various biological tissues, the investigation related to their adverse effects is a critical issue and required to be appropriately addressed before their biomedical applications. Short and long-term toxicity assessment of metal/metal oxide nanoparticles or their nano-formulations is of paramount importance to ensure the global biome's safety; otherwise, to face a fiasco. This article provides a comprehensive introspection regarding the effects of metal/metal oxides’ physical state, their surface properties, the possible mechanism of actions along with the potential future strategy for remediation of their toxic effects. © 2021 The Author(s)
Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy
(Frontiers Media S.A., 2021) Basanti Brar; Koushlesh Ranjan; Ankur Palria; Rajesh Kumar; Mayukh Ghosh; Sweety Sihag; Prasad Minakshi
Colorectal cancer (CRC) is the third most frequently occurring tumor in the human population. CRCs are usually adenocarcinomatous and originate as a polyp on the inner wall of the colon or rectum which may become malignant in the due course of time. Although the therapeutic options of CRC are limited, the early diagnosis of CRC may play an important role in preventive and therapeutic interventions to decrease the mortality rate. The CRC-affected tissues exhibit several molecular markers that may be exploited as the novel strategy to develop newer approaches for the treatment of the disease. Nanotechnology consists of a wide array of innovative and astonishing nanomaterials with both diagnostics and therapeutic potential. Several nanomaterials and nano formulations such as Carbon nanotubes, Dendrimer, Liposomes, Silica Nanoparticles, Gold nanoparticles, Metal-organic frameworks, Core-shell polymeric nano-formulations, Nano-emulsion System, etc can be used to targeted anticancer drug delivery and diagnostic purposes in CRC. The light-sensitive photosensitizer drugs loaded gold and silica nanoparticles can be used to diagnose as well as the killing of CRC cells by the targeted delivery of anticancer drugs to cancer cells. This review is focused on the recent advancement of nanotechnology in the diagnosis and treatment of CRC. Copyright © 2021 Brar, Ranjan, Palria, Kumar, Ghosh, Sihag and Minakshi.
Perspectives of millets for nutritional properties, health benefits and food of the future: a review
(Springer Nature, 2024) Pardeep Kumar Sadh; Ajay Kamboj; Suresh Kumar; Prince Chawla; Ravinder Kumar; Baljeet Singh Saharan; Dharmender Kumar; Surekha Duhan; Manju Nehra; Chhaya Goyal; Basanti Brar; Seema Joshi; Joginder Singh Duhan
In recent years, the increased prevalence of diseases associated with altered lifestyles, poor diet, and related awareness of natural therapies to treat these ailments has emphasized the study of bioactive compounds and natural small molecules. After the COVID-19 pandemic, people have become more concerned with their diet and healthy lifestyle. We need to replace grains with fortified foods that can help us fight nutritional security and provide a disease-free environment. Millets are nutritionally better than other cereals for human health. Millets are gluten-free, high in fiber content, and rich in minerals. Fiber-rich foods have a low glycaemic index and can reduce the risk of oxidative stress and metabolic illnesses. The 2023 year was dedicated to the International Year of Millets (IYM 2023). Hence, Millet varieties contain a large number of bioactive products like protocatechuic acid, vanillic acid, syringic acid, p-coumaric acid, catechin, ferulic acid, sinapic acid, quercetin, apigenin, taxifolin, kaempferol, luteolin and myricetin, β-sitosterol, campesterol, stigmasterol, and ergosterol etc. These bioactive compounds have potential health benefits, including various biological properties like anti-diabetic, anticancer, antioxidant, anti-inflammatory, anti-obesity, anti-hypertensive, cholesterol-lowering, immunomodulatory, and antimicrobial properties. The fermentation of millet can have the potential for an upsurge in their nutrient availability. Therefore, fermented foods have attracted much attention because of their potential health benefits. This review primarily focuses on recent developments in millet as a food, nutritional, and bioactive compound. It can potentially boost health and has implications for various fermented millet varieties. © The Author(s) 2024.
Unravelling the potential of sugarcane bagasse: An eco-friendly and inexpensive agro-industrial waste for the production of valuable products using pretreatment processes for sustainable bio-economy
(Elsevier Ltd, 2024) Ajay Kamboj; Pardeep Kumar Sadh; Babli Yadav; Annu Kumari; Ravinder Kumar; Surekha; Baljeet Singh Saharan; Basanti Brar; Dharmender Kumar; Chhaya Goyal; Joginder Singh Duhan
Sugarcane processing industries produce environmentally hazardous by-products in addition to desired production, and disposing of these by-products is a considerable problem. Developing a viable system for sustainable management of agro-industrial waste is imperative. Efficient and cost-effective technologies for turning biowaste into value-added products, as well as an assessment of soil quality and productivity, are needed in this approach. The biomass of agro-waste produced while sugarcane processing, sugarcane bagasse (SCB), is abundant worldwide. The abundance of this biomass in nature harnesses researchers to fulfill its various objectives, including energy and environmental sustainability. To scale this up for industrial applications, thorough research, scale-up studies, and evaluations of both techno-economic and ecological feasibility are critical. Sugarcane bagasse (SCB) is a biomass with great potential to help meet global energy needs, particularly in producing biofuels such as bioethanol and biogas, while contributing to environmental sustainability. Microorganisms, acting as bio-factories, are highly valuable due to their ability to produce various essential metabolites, including alcohols, enzymes, antibiotics, and other compounds. Fermenting SCB with microorganisms yields several industrially relevant enzymes, such as amylases, chitinases, and phytases, and demonstrates bioactive properties, including antioxidant, antimicrobial, anti-ageing, and anti-inflammatory effects. This review focuses on recovering value-added products from the SCB using various microbes, their short- and long-term impacts on the environment (air, water, and soil), living creatures, and their potential for sustainable bio-economy. © 2024 Elsevier Ltd