Browsing by Author "Bishal K. Singh"
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PublicationArticle Modeled structure of trypanothione reductase of Leishmania infantum(The Biochemical Society of the Republic of Korea, 2008) Bishal K. Singh; Nandini Sarkar; M.V. Jagannadham; Vikash K. DubeyTrypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.