Browsing by Author "Bismay Das"

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Double perineal Ani with duplication of external genitalia in a septicemic neonate: A case report
(Journal of Clinical and Diagnostic Research, 2018) Bismay Das; C. Mohanty; Rajniti Prasad; Braj Kishore Das
Double perineal ani, a rare congenital anomaly is due to persistence of urogenital septum with widening of hind gut. Only few cases have been reported in literature. We report a rare case of double perineal ani with duplication of external genitalia and ectopia vesicae in a septicaemic male child. Ultrasonography showed no duplication of internal organs. The treatment was started with intravenous cefotaxime and amikacin but died within 2 hours of admission. Autopsy could not be done. Early presentation to hospital and multidisciplinary approach is required for management of such cases. © 2018, Journal of Clinical and Diagnostic Research. All rights reserved.
Myofascial release versus other soft tissue release techniques along superficial back line structures for improving flexibility in asymptomatic adults: A systematic review with meta-analysis
(Churchill Livingstone, 2021) Neetu Rani Dhiman; Bismay Das; C. Mohanty; O.P. Singh; Vyom Gyanpuri; Dharma Raj
Objective: Our review is aimed to find out the efficacy of Myofascial Release Technique (MFRT) based on the Randomised Controlled Trials, on flexibility when given along superficial back line (SBL) structures and to compare it with other soft tissue release techniques. Data sources: A systematic literature search on MEDLINE (Pubmed), Google Scholar, Science direct, Cochrane Library, Physiotherapy Evidence Database (PEDro) and Clinical Trial Database in English; up to April 2020 was undertaken. Study selection: PRISMA (The Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols) was used for screening the relevant citations and reviewing the relevant studies. The literature searched total of 6,938 articles, however, only 68 were screened for eligibility. In the further screening, 16 studies fulfilled the inclusion criteria for our systematic review. Data extraction: Data were extracted into a table containing sample size, mean age of subjects, types of intervention, area to be treated, outcome measures used, and results of the accepted studies. Data synthesis: 16 randomized controlled trials and cross-over trials were found to be eligible for our review. Quality assessment of the RCTs was done with the PEDro scoring method. Randomised clinical trials that studied the comparative effect of Myofascial Release (MFRT) technique with different MFRT techniques, control/sham, and other soft tissue release techniques like stretching, were included. Results of this analysis showed little evidence proving the additional effectiveness of MFRT treatment compared to other soft tissue release techniques for improving flexibility so as to consider it as the preferred treatment. Methodological aspects of selected studies for further research are suggested. Study was registered in the PROSPERO database (CRD42020179118). Conclusion: MFRT appears to be a good technique for improving flexibility. However, in comparison with other soft tissue release techniques, this therapy becomes less successful. More research is needed regarding its effectiveness. © 2021 Elsevier Ltd
Prognostic significance of mast cells and vascular density in prostatic adenocarcinoma
(Wolters Kluwer Medknow Publications, 2022) Bismay Das; Susan M. Mendonca
Context: Though mast cells infiltrate solid tumors, the exact role of mast cells in tumor biology is controversial. Mast cell density (MCD) may vary depending on its location in the tumor and tumor vascularity. MCD may influence the tumor aggressiveness. Aims: This study evaluates MCD and tumor vascularity in different histopathological grades of adenocarcinoma prostate. Settings and Design: Descriptive study with purposive sampling. Methods and Material: The subjects of study were 42 adenocarcinoma patients. 20 cases were of intermediate grade (Gleason score 2-7) and 22 were of high-grade (Gleason score 8-10). Histological diagnosis was made by examining sections stained with hematoxylin and eosin. Additional sections from the same block were stained for mast cells using Giemsa stains as per standard protocol. Mast cell count was done in minimum six random high-power microscopy fields in four different regions- intratumoral, peritumoral, stromal and perivascular regions. Statistical Analysis Used: SSPS software version 13.0. Descriptive statistics, Student's t test and ANOVA test. Results: In high-grade adenocarcinoma, mast cell counts were higher in perilesional, stromal and perivascular regions, whereas it was lower in intralesional areas as compared to the intermediate grade. However, statistical significance was observed only for the perivascular region. There was significantly higher number of blood vessels in high-grade adenocarcinoma as compared to intermediate grade adenocarcinoma. Conclusions: In this study, perilesional mast cells and vascularity increased with increased severity of adenocarcinoma. These findings suggest a possible influence of mast cells on the tumor microenvironment such as vessel density and aggressiveness of tumor. However, further studies are required to substantiate results of this study. © 2022 Indian Journal of Public Health.
Rapid screening of dengue fever using research parameters from new generation hematological analyzers
(John Wiley and Sons Inc, 2022) Gaurav Chhabra; Bismay Das; Shruti Mishra; Baijayantimala Mishra
Introduction: The early diagnosis of dengue fever and its differentiation from other causes of acute febrile illness is essential for a better outcome. The new generation automated hematology analyzers provide parameters like high fluorescence lymphocyte count (HFLC) and leukocyte cell population data (CPD) representing various leukocytes. We tried to analyze the utility of these parameters in the rapid screening of dengue fever. Methods: The HFLC and the leukocytic CPD from the Sysmex XN1000 analyzer were obtained for 299 cases presenting with acute febrile illness, which included 97 dengue-positive and 202 cases dengue-negative controls. Additionally, 100 healthy controls were also included. The Receiver operative curves (ROC) were drawn to obtain a cut-off value for these parameters for discriminating among the dengue-positive and dengue-negative subgroups and healthy controls. Results: The dengue-positive cases showed a significantly increased HFLC among the different groups of controls. The median (range) HFLC% was 1.9(0.30–6.55), 0.20(0.10–0.70), and 0.10(0.0–0.30) in the cases that were positive for dengue, negative for dengue, and healthy controls, respectively. The ROC analysis revealed HFLC% at a cut-off value of 1.75 which can discriminate between dengue-positive and dengue-negative patients, with 52% sensitivity, 90% specificity, 72% positive predictive value (PPV), and 80% negative predictive value (NPV). The regression analysis revealed LY-X, LY-Z, Ly-WX, LY-WZ, and MO-X as independent predictors for dengue fever. Conclusion: The HFLC and CPD obtained from Sysmex XN1000 hematology analyzer are valuable tools in rapidly screening dengue infection from other febrile illnesses in routine practice. © 2022 John Wiley & Sons Ltd.