Browsing by Author "Chandra Kant"

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An insight into the molecular docking interactions of plant secondary metabolites with virulent factors causing common human diseases
(Elsevier B.V., 2022) Ajay Kumar; Sandeep Kumar Singh; Vipin Kumar Singh; Chandra Kant; Amit Kishore Singh; Vijay Tripathi; Kalpna Singh; Vijay Kumar Sharma; Joginder Singh
Plant natural products or secondary metabolites have gained significant attention globally because of discoveries of semi-synthetic drugs novel bioactive compounds. Currently, a large part of global population relies on natural products to cure ailments and even chronic diseases and to enhance their immune system. Interestingly, the commonly used drugs for the treatment of some common human diseases like cancer, ulcer, tuberculosis, asthma, etc., have been reported to be of plant origin and recognized to elicit beneficial effects in virulent factors of diseases in vivo and in vitro. The herbal drugs are economical and considered as safe upto certain extent from major side effects. But, still there is need of rapid collection, characterization, taxonomy, certification, and storage for broad, efficient and effective use in drug design or discovery. In this review, we summarized the plants derived secondary metabolites used in treating common human diseases and emphasised the protein-ligand interactions between virulent factors of diseases namely Insulin, p53, Proteasome-associated ATPase, Enterotoxin, Choleragen, IgE with secondary metabolites Aloin, Sesamin, Alliin, Flavanon, Salannin Octyl-β-d-Glucopyranoside of plants respectively, through molecular docking. This study will play a valuable and effective role in drug designing and screening plant-derived metabolites for drug designing. © 2021 SAAB
Biocontrol Potential of Microbial Consortia: Approaches in Food Security and Disease Management
(Springer International Publishing, 2022) Hariom Verma; Chandra Kant; Sandeep Kumar Singh; James F. White; Ajay Kumar; Samir Droby
In the current scenario of climate change, the uncertainty of environmental factors and adverse impacts of chemical pesticides on the texture and productivity of soil along with increasing health concerns to humans appear as a global challenge in the management of agricultural yield to meet the food demand of burgeoning global populations. However, microbial consortia applied as either plant or soil inoculants have largely been used in the last few decades for the enhancement of agricultural productivity, improvement of nutrient status in the soil, improvement of fruit quality, and as biocontrol agents to control the growth of devastating phytopathogens during harvest or postharvest storage. The functional aspects of microbial consortia have been shown effective in broader ways as compared to individual cultures. Moreover, the efficiency of microbial consortia is higher due to the presence of several strains where each strain performs specific functions and shows better performance in functional behaviours in order to withstand environmental fluctuations. In this chapter, we have tried to compile the latest aspects and advancements in the development and application of microbial consortia for effective phytopathogen control so that the goals of food security could be achieved. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
Bioformulation Containing Cohorts of Ensifer adhaerens MSN12 and Bacillus cereus MEN8 for the Nutrient Enhancement of Cicer arietinum L.
(MDPI, 2022) Nitin Baliyan; Kamal A. Qureshi; Mariusz Jaremko; Minakshi Rajput; Monika Singh; Sandhya Dhiman; Dinesh Kumar Maheshwari; Chandra Kant; Ajay Kumar
Here we examine the effects of different carrier based bioinoculants on the growth, yield and nutritional value of chickpea and on associated soil nutrients. A consortium of two taxonomically distinct endophytic bacteria—Ensifer adhaerens MSN12 and Bacillus cereus MEN8—have promising plant growth promoting (PGP) attributes. We demonstrate their delivery from the laboratory to the field via the formulation of an effective bioinoculant with economic and accessible carriers. Sugarcane straw ash (SCSA) was found to be an efficient carrier and bioformulation for enhancing viability and shelf-life of strains up to 12 months. A bioformulation containing an SCSA-based consortium (MSN12 + MEN8) increased seed germination by 7%, plant weight by 29%, length by 17%, seed-yield by 12%, harvesting index by 14% and proximate nutritional constituents by 20% over consortium treatment without SCSA. In addition, the bioformulation of post-harvest treated soil improved the physico-chemical properties of the soil in comparison to a pre-sowing SCSA-based bioformulation treated crop, being fortified in different proximate nutritional constituents including dry matter (30%), crude protein (45%), crude fiber (35%), and ether extract (40%) in comparison to the control. Principal component analysis and scattered matrix plots showed a positive correlation among the treatments, which also validates improvement in the soil nutrient components and proximate constituents by T6 treatment (MSN12 + MEN8 + SCSA). The above results suggest efficiency of SCSA not only as a carrier material but also to support microbial growth for adequate delivery of lab strains as a substitute for chemi-fertilizers. © 2022 by the authors.
Microbial biosurfactant: A new frontier for sustainable agriculture and pharmaceutical industries
(MDPI, 2021) Ajay Kumar; Sandeep Kumar Singh; Chandra Kant; Hariom Verma; Dharmendra Kumar; Prem Pratap Singh; Arpan Modi; Samir Droby; Mahipal Singh Kesawat; Hemasundar Alavilli; Shashi Kant Bhatia; Ganesh Dattatraya Saratale; Rijuta Ganesh Saratale; Sang-Min Chung; Manu Kumar
In the current scenario of changing climatic conditions and the rising global population, there is an urgent need to explore novel, efficient, and economical natural products for the benefit of humankind. Biosurfactants are one of the latest explored microbial synthesized biomolecules that have been used in numerous fields, including agriculture, pharmaceuticals, cosmetics, food processing, and environment-cleaning industries, as a source of raw materials, for the lubrication, wetting, foaming, emulsions formulations, and as stabilizing dispersions. The amphiphilic nature of biosurfactants have shown to be a great advantage, distributing themselves into two immiscible surfaces by reducing the interfacial surface tension and increasing the solubility of hydrophobic compounds. Furthermore, their eco-friendly nature, low or even no toxic nature, durability at higher temperatures, and ability to withstand a wide range of pH fluctuations make microbial surfactants preferable compared to their chemical counterparts. Additionally, biosurfactants can obviate the oxidation flow by eliciting antioxidant properties, antimicrobial and anticancer activities, and drug delivery systems, further broadening their applicability in the food and pharmaceutical industries. Nowadays, biosurfactants have been broadly utilized to improve the soil quality by improving the concentration of trace elements and have either been mixed with pesticides or applied singly on the plant surfaces for plant disease management. In the present review, we summarize the latest research on microbial synthesized biosurfactant compounds, the limiting factors of biosurfactant production, their application in improving soil quality and plant disease management, and their use as antioxidant or antimicrobial compounds in the pharmaceutical industries. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.