Browsing by Author "D. Bhattacharya"

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5-Fluorouracil and 5-fluorouracil-histidine complexes with AlIII, CrIII and FeIII ions and their antitumour activity
(Elsevier Ltd, 1997) Krishan K. Narang; Vinod P. Singh; D. Bhattacharya
Complexes of the type [M(L-H)(OH)Cl], [Cr(L-H)(H2O)2(OH)Cl] and [M′(L-H)(L′-H)(H2O)Cl], where L = 5-fluorouracil; L′ = histidine (HISD); M = AlIII or FeIII and M′ = AlIII, CrIII or FeIII were synthesized and characterized. The complexes are insoluble in water and common organic solvents. 5-Fluorouracil is coordinated to the metal ion through the O atom of C(4)=O and the N atom of N(1) while histidine coordinates through the O atom of - COO- and the N atom of - NH2 groups. The μeff values, electronic spectral bands and ESR spectra suggest a polymeric 6-coordinate spin free octahedral stereochemistry for CrIII and FeIII complexes. The in vivo antitumour effect of 5-fluorouracil and its complexes was examined on C3H/He mice against P815 murine mastocytoma. As evident from their T/C values CrIII and FeIII complexes display significant and higher antitumour activity compared to 5-fluorouracil while the AlIII complexes show lower activity. The in vitro results of the complexes on the same cells indicate that CrIII and FeIII complexes show higher inhibition on 3H-thymidine and 3H-uridine incorporation in DNA and RNA replication, respectively. © 1997 Elsevier Science Ltd.
Aluminium(III), chromium(III) and iron(III) complexes with 5-iodouracil and 5-iodouracil-histidine and their antitumour activity
(2009) Vinod P. Singh; Shweta Singh; K.K. Narang; D. Bhattacharya
Complexes of the type [Al(HL)(OH)Cl2], [M(HL)(OH)2 Cl] and [M′(HL)(L′)(OH)Cl], where HL = 5-iodouracil; HL′ = histidine; M = Cr(III), Fe(III) and M′ = Al(III), Cr(III), Fe(III), were synthesized and characterized. The complexes are polymeric showing high decomposition points and are insoluble in water and common organic solvents. The μeff values, electronic spectral bands and ESR spectra suggest a polymeric 6-coordinate spin-free octahedral stereochemistry for the Cr(III) and Fe(III) complexes. 5-Iodouracil acts as a monodentate ligand coordinating to the metal ion through the O atom of C(4) = O while histidine through the O atom of -COO- and the N atom of -NH2 group. In vivo antitumour effect of 5-iodouracil and its complexes was examined on C3H/He mice against P815 murine mastocytoma. As evident from their T/C values, Cr(III) and Fe(III) complexes display significant and higher antitumour activity compared to the 5-iodouracil ligand. The in vitro results of the complexes on the same cells indicate that Cr(III) and Fe(III) complexes show higher inhibition on 3 H-thymidine and 3H-uridine incorporation in DNA and RNA replication, respectively, at a dose of 5 μg/mL.
Effect of banana powder (Musa sapientum var. paradisiaca) on gastric mucosal shedding
(1987) K. Mukhopadhyaya; D. Bhattacharya; A. Chakraborty; R.K. Goel; A.K. Sanyal
Banana pulp powder (Musa sapientum Linn. var. paradisiaca) was studied for its effects on gastric mucosal resistance. Banana-treated (0.5 g/kg orally, twice daily for 3 days) rats of either sex showed: (i) a significant increase in the [3H]thymidine incorporation into mucosal cell DNA; (ii) a significant increase in the total carbohydrate (sum of total hexoses, hexosamine, fucose and sialic acid) content of gastric mucosa; (iii) a significant decrease in gastric juice DNA and protein; (iv) a significant increase in the total carbohydrates and carbohydrate/protein ratio of gastric juice. Aspirin treatment to rats caused similar effects as banana on the [3H]thymidine incorporation into mucosal cell DNA but showed opposite effects on the other parameters. These results suggest that banana treatment increased and aspirin decreased the gastric mucosal resistance as evidenced by a respective decrease and increase in gastric juice DNA, the latter serving as an index of the rate of mucosal shedding. Increased cellular mucus may be the factor for increased mucosal resistance. The results of the present study tend to confirm that plantain banana powder strengthens mucosal resistance and promotes the healing of ulcers. © 1987.
Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart
(Urban und Fischer Verlag Jena, 2002) Salil K. Bhattacharya; D. Bhattacharya; K. Sairam; S. Ghosal
The tannoid principles of the fruits of Emblica officinalis have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin-A (37%) and -B (33%) enriched fraction of fresh juice of Emblica fruits (EOT) was investigated for antioxidant activity against ischemia-reperfusion (IRI)-induced oxidative stress in rat heart. Vitamin E (VE) was used as the standard antioxidant agent. IRI was induced in isolated rat heart by perfusing it with modified Kreb-Hensleitt's solution for 5 min, followed by a period of ischemia (stoppage of perfusion) for 10 min and then restoring the perfusion (reperfusion) for 15 min. IRI induced a significant decrease in the activities of cardiac superoxide dismutase, catalase and glutathione peroxidase, with a concomitant increase in lipid peroxidation. These IRI-induced effects were prevented by the administration of EOT (50 and 100 mg/kg body wt.) and VE (200 mg/kg body wt.) given orally twice daily for 14 days prior to the sacrifice of the animals and initiation of the perfusion experiments. The study confirms the antioxidant effect or E. officinalis and indicates that the fruits of the plant may have a cardioprotective effect.
Effect of Emblica officinalis tannoids on a rat model of tardive dyskinesia
(2000) S.K. Bhattacharya; D. Bhattacharya; A.V. Muruganandam
Effect of active tannoid principles of E. officinalis, comprising of emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%), was investigated on a rat model of tardive dyskinesia (TD) induced by once daily administration of haloperidol (1.5 mg/kg, ip) for 28 days. Involuntary orofacial movements (chewing movements, buccal tremors and tongue protusion) were assessed as TD parameters. The tannoid principles of E. officinalis (EOT) were administered concomitantly with haloperidol in the doses of 10, 20 and 50 mg/kg, po, for 28 days. Sodium valproate (200 mg/kg, po), a Gaba-mimetic agent, and vitamin E (400 mg/kg, po), an antioxidant, were used as the standard drugs and administered for the same period. EOT induced a dose-related inhibition of all the three TD parameters assessed, as did vitamin E. The effect of sodium valproate remained statistically insignificant. The results suggest that EOT exerts a prophylactive effect against neuroleptic-induced TD which is likely to be due to its earlier reported antioxidant effects in rat brain areas, including striatum.
Effect of restraint stress on anticonvulsant actions of phenobarbitone & diphenylhydantoin in rats
(1982) S.K. Bhattacharya; D. Bhattacharya
Restraint stress (1, 2 and 4 hr) produced a time-related potentiation of the anticonvulsant activity of sub-anticonvulsant (ED0) dose (2.5 mg/kg, ip) of phenobarbitone (PB) and diphenylhydantoin (DPH), against maximal electroshock-induced seizures in rats. Restraint stress (4 hr)-induced potentiation of PB and DPH anticonvulsant actions were significantly attenuated after pharmacological treatments known to inhibit central serotonergic and prostaglandin (PG) activity, but were unaffected by drug-induced inhibition of endogenous corticoid synthesis. The results suggest the involvement of serotonin and PGs, but not endogenous corticoids, in restraint stress effects on PB and DPH actions.
Effect of restraint stress on rat brain serotonin
(Springer India, 1982) S.K. Bhattacharya; D. Bhattacharya
Restraint-induced stress in rats was found to enhance steady state concentrations of whole brain and hypothalamic serotonin, at 1,2 and 4 h after immobilization. The increase was maximal at 1 h and tended to decline thereafter. The rate of accumulation of rat brain serotonin, in pargyline pretreated animals, was significantly enhanced after restraint stress. Bilateral adrenalectomy and metyrapone, an endogenous corticoid synthesis inhibitor, failed to affect restraint stress (1h)-induced increase in rat brain serotonin levels. Thus restraint stress-induced autoanalgesia and potentiation of the pharmacological actions of several centrally acting drugs, in rats, are serotonin-mediated responses. The results also indicate that restraint stress-induced effects on rat brain serotonin are not dependent on endogenous corticoid activity. © 1982 Indian Academy of Sciences.
Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia
(Urban und Fischer Verlag Jena, 2002) Salil K. Bhattacharya; D. Bhattacharya; K. Sairam; S. Ghosal
Withania somnifera glycowithanolides (WSG) were investigated for their preventive effect on the animal model of tardive dyskinesia (TD), induced by once daily administration of the neuroleptic, haloperidol (1.5 mg/kg, i.p.), for 28 days. Involuntary orofacial movements (chewing movements, tongue protusion and buccal tremors) were assessed as TD parameters. WSG (100 and 200 mg, p.o.), administered concomitantly with haloperidol for 28 days, inhibited the induction of the neuroleptic TD. Haloperidol-induced TD was also attenuated by the antioxidant, vitamin E (400 and 800 mg/kg, p.o.), but remained unaffected by the GABA-mimetic antiepileptic agent, sodium valproate (200 and 400 mg/kg, p.o.), both agents being administered for 28 days like WSG. The results indicate that the reported antioxidant effect of WSG, rather than its GABA-mimetic action, may be responsible for the prevention of haloperidol-induced TD.
Growth, synthesis and characterization of large grain CuInSe2 in bulk and thin film form
(1988) R.J. Gupta; D. Bhattacharya; O.N. Srivastava
Growth of large grain form of CuInSe2 has been described and discussed. It has been shown that specific treatments such as Cd/Bi doping of the as-synthesized polycrystalline CuInSe2 bulk flux and localized annealing (∼600°C) of the as-deposited polycrystalline CuInSe2 thin films lead to large grain (bulk: 1000 μm, thin film: 10 μm) CuInSe2. © 1988.
Prostaglandin synthesis inhibitors reduce cannabis and restraint stress induced increase in rat brain serotonin concentrations
(1983) S.K. Bhattacharya; D. Bhattacharya
Cannabis resin (Cl) produced a dose-related increase in rat brain serotonin concentrations, whereas restraint stress produced maximal rise of the neurotransm itter concentrations at 1 h, followed by a tendency to normalise by 4 h. The prostaglandin (PG) synthesis inhibitors, diclofenac and paracetamol, antagonized Cl and restraint stress induced rise in serotonin concentrations. The findings lend credence to earlier reports that PG synthesis inhibitors antagonize serotonin-mediated neuropharmacological actions of Cl and restraint stress in rats. © 1983, Walter de Gruyter. All rights reserved.
Restraint stress-induced potentiation of hexobarbitone hypnosis in the rat - Role of putative neurotransmitters
(1982) S.K. Bhattacharya; D. Bhattacharya
[No abstract available]
Synthesis, characterization and antitumour activity of 5-chlorouracil and 5-chlorouracil-histidine complexes with some metal(III) ions
(Marcel Dekker Inc., 1998) Krishan K. Narang; Vinod P. Singh; D. Bhattacharya
Complexes of the type [AlL(OH)Cl], [ML(OH)2] and [M1LL1(H2O)Cl], where HL = 5-chlorouracil; HL1 = histidine; M = Cr(III) or Fe(III) and M1 = Al(III), Cr(III) or Fe(III), were synthesized and characterized. The complexes are polymeric in nature showing high decomposition points and are insoluble in water and common organic solvents. 5-Chlorouracil is coordinated to the metal ion through the O atom of C(4)=O and the N atom of N(1), while histidine through the O atom of -COO- and the N atom of -NH2 group. The μcff values, electronic spectral bands and ESR spectra suggest a polymeric 6-coordinate spin-free octahedral stereochemistry for the Cr(III) and Fe(III) complexes. In vivo and in vitro antitumour activity results indicate that the Cr(III) complexes have significant activity against P815 murine mastocytoma but the Al(III) complexes show poor activity.
Synthesis, characterization and antitumour activity of uracil and uracil-histidine complexes with metal(III) ions
(Springer Netherlands, 1997) Krishan K. Narang; Vinod P. Singh; D. Bhattacharya
Complexes of the [Al(L-H)(OH)Cl], [M(L-H)(H2O)2-(OH)Cl] and [M′(L-H)(L′-H)(H2O)Cl] type, where L = uracil (URL); L′= histidine (HISD); M = CrIII or FeIII and M′= AlIII, CrIII or FeIII were synthesized and characterized. The complexes are polymers, with high decomposition points and are insoluble in water and common organic solvents. Uracil is coordinated to the metal ion through the O atom of C(4)=O and the N atom of N(1), while histidine coordinates through the O atom of -CO-2 and the N atom of the -NH2 groups. The μeff values, electronic spectral bands and e.s.r. spectra suggest a polymeric six coordinate spin-free octahedral stereochemistry for the CrIII and FeIII complexes. The in vivo and in vitro antitumour activity results indicate that CrIII and FeIII complexes have significant activity against P815 murine mastocytoma but AlIII complexes show poor activity.