Browsing by Author "D.C. Roy"

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5-year follow-up of cytotoxic chemotherapy as an adjuvant to surgery in carcinoma of the bronchus
(1976) H. Stott; R.J. Stephens; W. Fox; D.C. Roy
This report gives the 5-year findings of a double-blind study of long-term cytotoxic chemotherapy as an adjuvant to surgery in patients receiving busulphan or cyclophosphamide for carcinoma of the bronchus compared with a group receiving a placebo. Of 243 patients initially allocated busulphan, 234 cyclophosphamide and 249 placebo, 28%, 27% and 34% respectively were alive at 5 years. There were significant associations between mortality from bronchial carcinoma and histological involvement of the resected intrathoracic nodes and the histology of the tumour. Haematological toxicity, especially thrombocytopenia, was frequent and severe in the busulphan series, and low platelet counts continued long after chemotherapy was stopped. © 1976, The British Empire Cancer Campaign for Research. All rights reserved.
Allergic bronchopulmonary aspergillosis
(1982) S.K. Agarwal; D.C. Roy
[No abstract available]
An evaluation of percutaneous trephine biopsy in the diagnosis of lung diseases
(1974) D.C. Roy; M.L. Mehrotra
In this series of 80 consecutive lung biopsies using the trephine, definitive diagnosis was obtained in 67 (84%) of the cases, with a variety of diffuse and localized lung lesions. No serious complications occurred in this series; there was no instance of death, air embolism or infection. This procedure was found to have several advantages, that it is painless, quick and can be performed at the bedside. It can be repeated if and when necessary and is inexpensive compared with open biopsy.
Electrocardiographic abnormalities in tropical pulmonary eosinophilia.
(1990) S.K. Agarwal; D.C. Roy; A. Johri
A 12 lead electrocardiogram in 70 patients with tropical pulmonary eosinophilia showed abnormalities 28.57%. ECG changes observed were right axis deviation (10%), 'P' pulmonale (10%), clockwise rotation (5.7%), right ventricular hypertrophy (1.4%), partial RBBB (2.8%), first degree A-V block (1.4%) and ST-T changes (1.4%). All ECG changes reverted back to normal after diethyl carbamzine therapy in the dose of 10 mg/kg body weight for a total duration of 14 days.
Ethambutol in the retreatment of multi resistant advanced pulmonary tuberculosis (salvage cases)
(1974) D.C. Roy; P.C. Sen; B.K. Bajpai
This report summarizes the results obtained in the retreatment of pulmonary tuberculosis with EMB alone and in combination with other reserve drugs in 38 patients who had failed to respond to previous chemotherapy involving the use of primary as well as of secondary drugs. There were 11 patients who received EMB alone as the effective antituberculosis drug. In addition, 15 patients received EMB, with one other effective reserve drug and twelve patients were treated with EMB plus two other effective reserve drugs. EMB was given in a dosage of 25 mg/kg/day for the first 60 days, thereafter 15 mg/kg/day. There were eight patients who failed to become culture negative for tubercle bacilli, plus 6 cases who relapsed during the period of retreatment. However, 24 patients (63%) became consistently culture negative, demonstrating an excellent therapy response. Intolerance sufficient to require drug withdrawal was encountered in one patient on Ethambutol (3%). The results suggest that EMB is an effective antituberculosis drug and can be used safely in the chemotherapy of retreatment.
Evaluating renal status in pulmonary tuberculosis: case of rural and urban patients in eastern UP
(1993) J.K. Mishra; D.C. Roy
Tuberculosis is one of the commonest health hazards in India, involving kidneys very frequently, the incidence level being next to pulmonary tuberculosis. This study is aimed at knowing the exact incidence and histological character of renal tuberculosis. This study also attempts to evaluate the progressive factors in different histopathological varieties. By trying different antitubercular regimens on these patients of renal turberculosis, we will be in the position to recommend a particular mode of therapy for the treatment of renal tuberculosis which may help to reduce the cost and period of treatment as well as to reduce the chances of transmission. -from Authors
Evaluating respiratory allergy in Varanasi and environs
(1990) D.C. Roy; J.K. Mishra
[No abstract available]
Extramedullary plasmacytoma IgG type I presenting as mediastinal syndrome
(1974) R.M. Gupta; D.C. Roy; I.M. Gupta; S. Khanna
The case is reported of a young man with extramedullary plasmacytoma presenting with massive cervical lymphadenopathy, pleural effusion and purplish papules on the chest wall. Histopathology of a lymph node from the neck revealed a plasmacytoma. Immunochemical studies on serum and pleural fluid showed M paraprotein of IgG type I. © 1974.
Intermittent chemotherapy in retreatment cases of pulmonary tuberculosis
(1985) S.K. Agarwal; D.C. Roy; S.C. Matah
[No abstract available]
Liver damage in chronic non tuberculous respiratory diseases
(1974) V.K. Jha; K. Kotilingam; D.C. Roy; P.K. Shukla; M. Joshi
Twenty two cases of chronic non tuberculous respiratory diseases were studied for the evidence of liver damage. Out of them 6 were of malignancies, 9 of allergic conditions and 7 of suppurative diseases. Bromsulfphthalein thymol turbidity, bilirubin, alkaline phosphatase, pseudocholinesterase, lactate dehydrogenase (LDH) and LDH5, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, total serum protein, albumin were estimated in them. In 7 cases liver biopsy was also performed. A varying degree of biochemical evidence of liver damage was found. Liver biopsy showed histological evidence in 6 out of 7 cases. It was found that multiple tests of liver function performed simultaneously are more useful than a single test for the diagnosis of the liver damage.
Liver function in extra pulmonary tuberculosis
(1975) V.K. Jha; K. Kotilingam; D.C. Roy
[No abstract available]
Liver function in pulmonary tuberculosis
(1974) V.K. Jha; K. Kotilingam; P.K. Shukla; D.C. Roy; M. Joshi
[No abstract available]
Lung biopsy by manually operated high speed air drill. (Preliminary communication)
(1973) D.C. Roy; M.L. Mehrotra; K. Kotilingam
Thirty percutaneous trephine lung biopsies were performed on 27 patients, (9 with localised peripheral lung lesions and 18 with diffuse parenchymal disease) aged between 12 and 62 yr. A definitive histopathologic diagnosis was achieved in 90% of the patients. The most common complications were pneumothorax (20%) and hemoptysis (16.6%). There was no instance of mortality through air embolism. It is concluded that percutaneous trephine lung biopsy with high speed air drill is safe and in certain cases may be an acceptable alternative to open lung biopsy without reducing the chances of diagnosis.
Once a week short-term tuberculosis therapy
(1983) S.K. Agarwal; D.C. Roy; D. Pal
Seventy patients were used as subjects for the present study from among those in the Tuberculosis Chemotherapy Unit, University Health Centre, Banaras Hindu University and were randomly designated to either the five month intermittent regimen or the twelve month standard regimen. Fifteen patients were excluded from the main analysis either due to drug toxicity or non-compliance. There was a significant difference in drug default in the short-term regimen (3.3%) in comparison to the standard regimen (17.5%). Radiological improvement was observed following three months (P<0.005). After a period of five months (P<0.001) statistically significant differences were also observed. Bacteriological conversion occurred faster in the rifampicin containing regimen. Three (10%) patients on rifampicin showed 'flu-like' symptoms, while four (13.33%) exhibited muscular weakness. Two (5%) patients on thiacetazone suffered from exfoliative dermatitis, and streptomycin toxicity occurred in five (7.15) patients. A twelve month post-study revealed a relapse in 3.7% of the patients in the short-term regimen and 7.14% of those in the standard regimen.
Pulmonary alveolar microlithiasis.
(1991) S.K. Agarwal; D.C. Roy; A. Johri
[No abstract available]
Role of nandrolone phenylpropionate in the chemotherapy of pulmonary tuberculosis (short course chemotherapy). A controlled clinical trial
(1982) D.C. Roy; S. Agarwal; S.P. Ganguli
Durabolin employed with anti-tuberculous chemotherapy acts as a non-specific therapeutic adjuvant. The administration of the drug did not provoke any hyper-androgenic activity.
Sino bronchial syndrome
(1980) H.C. Samant; B.K. Samant; D.C. Roy
[No abstract available]