Browsing by Author "D.N.S. Gautam"

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In-vivo potential of Musa paradisiaca Linn. (Stmn.) in streptozotocin-induced diabetic rats
(Medknow Publications, 2016) Mishra Ashish; K.R.C. Reddy; D.N.S. Gautam; S.K. Maurya; Seth Ankit
Objective: Musa paradisiaca belonging to family Musaceae is a well-known herb having many pharmacological properties including antidiabetic activity. In ancient text, Basavaraju was reported the stamen of this plant as antidiabetic agent in a dietary recipe. The main aim of this study was to explore the in-vivo antidiabetic property of its stamen. Materials and Methods: Aqueous extract of M. paradisiaca stamen (AqMP, 100, 200, and 400 mg/kg, p.o.) was evaluated for hypoglycemic effect in normoglycemic rats and consequences on oral glucose tolerance test (OGTT) by measuring the tail blood glucose concentrations. Further, blood glucose level was measured after 7th, 14th, and 21th days in streptozotocin-nicotinamide (STZ 65 mg/kg, i.p. and NDA 110 mg/kg, i.p.) induced-diabetic rats treated with AqMP and reference drug glibenclamide (5 mg/kg, b.w. p.o.). Results: The result with normoglycemic rats shows that the AqMP (400 mg/kg, p.o.) did not have any hypoglycemic effect, and it effectively control the blood glucose level in OGTT within 30-60 min after glucose (2 g/kg) administration without causing any hypoglycemic effect. Moreover, the drug (400 mg/kg, p.o.) was also found to be effective in controlling the blood sugar level in STZ-NDA induce diabetic rat as compare to glibenclamide. Conclusion: The study shows that the drug exhibit significant in-vivo antidiabetic potential as well as support its traditional use in diabetes.
Pharmaceutics, ethnopharmacology, chemistry and pharmacology of ayurvedic marine drugs: A review
(International Journal of Research in Ayurveda and Pharmacy, 2013) Satadru Palbag; Kuntal Pal; Dhiman Saha; M.K. Nandi; B.K. De; D.N.S. Gautam
Ayurveda is the ancient thought and treatise that are being used in the Ayurvedic mode of treatment. The source of these drugs is diverse and belongs to different category. The category ranges from plants and animals to minerals, and encircles around different types of species of plants and animals with vivid habitats. In the course of last thirty years, marine organisms have been proven to be a rich source of wide range of worthy compounds for medicine. In Ayurveda there is a wide range of marine drugs like Mukta, Varatika, Praval, Agnijvar, Samudra phena, etc that are useful in the management of numerous diseases like paralysis, hyperacidity, cancer, dyspepsia, eye diseases, etc. This review makes a humble effort to summarize and gather knowledge about different types of marine drugs that are described and explained in Ayurvedic system of medicine, its traditional processing and chemistry, ethno pharmacology and pharmacological role.
Pharmacognostical and phytochemical study of Musa paradisiaca Linn. (Stmn.)
(BRNSS Publication Hub, 2017) Mishra Ashish; K.R.C. Reddy; S.K. Maurya; Seth Ankit; D.N.S. Gautam
Background and Aim of Study: The main aim of this research is to establish a standardized data regarding its safety through including certain parameters. Kadali (Musa paradisiaca) Linn. (Musaceae) is a perennial herb which is like a tree and is used in Ayurvedic system of medicine to cure many diseases. Materials and Methods: In the present study, pharmacognostical and phytochemical standardization of plant material was performed as per the guidelines of World Health Organization. Results: The stamen of M. paradisiaca is brownish black or dull in color, slightly smooth and 0.9-1.6 cm long depending on the maturity of stamen. Powdered microscopy of stamen of M. paradisiaca shows some fiber vascular tissues, prism-like calcium oxalate crystal, pigmented sclereids, and spherical pollen grains. Physicochemical parameters including loss on drying (5.5% w/w), total ash (5.81%), water-soluble ash (3.79% w/w), acid-insoluble ash (2.61% w/w), water-soluble extractive (7.17% w/w), methanol-soluble extractive (2.38% w/w), hexane-soluble extractive (1.44% w/w), ethyl acetate-soluble extractive (2.24% w/w), and petroleum ether-soluble extractive (4.0% w/w) were evaluated. Phytochemical screening of aqueous and methanolic extracts showed the presence of alkaloids, carbohydrates, saponins, tannins, and phenols. Safety and efficacy of plant drug was further performed through evaluating heavy metals (Zn, Cd, and Pb). Heavy metals are discovered within the permissible limits. Conclusion: The diagnostic characters of stamen will give the necessary information regarding its identification. Its physiochemical and phytochemical evaluation provides information which accounts for the safety, identification, and class of chemical constituents present in this crude drug.
Physico-chemical characterization and in-vivo evaluation of Jasad Bhasma: An Indian traditional biomedicine
(2012) S.K. Singh; A.K. Singh; D.N.S. Gautam; A. Trigunayat; M. Kumar; S.B. Rai
Indian traditional system of medicine Ayurveda makes use of herb and metal based preparations called Bhasma (literal meaning ash) which are prepared by several processing steps including repeated calcinations of the metal in the presence of herbal constituents (juices, decoctions, powders, etc). These medicines are very effective; however, standardization of such medicines as to their preparation, composition, structure, toxicity, and mechanism of action, etc is a challenging but necessary task. Present work on Zinc based Jasad Bhasma is an attempt to unravel the science behind such preparations and also to establish a general parameter to standardize them. Jasad Bhasma has been prepared using strict protocol listed in Ayurveda texts. Further, the final prepared medicine and the material in intermediate steps of the processing of the medicine both have been characterized. In-vivo evaluation of the drug has also been carried out. Our analysis suggests that different stages of the processing of the medicine convert the metallic Zn into ZnO with reduction in particle size in sub-micrometer range. A small fraction of the particles also lies in nano regime (<100 nm). In addition, presence of biocompatible material (like silica and carbon compound) and nutrient elements is also observed in the medicine due to natural precursors used during the preparation of the medicine. The medicine has been found safe under the recommended dosages.
Synthesis, characterization and histopathological study of a lead-based Indian traditional drug: Naga Bhasma
(2010) S.K. Singh; D.N.S. Gautam; M. Kumar; S.B. Rai
The aim of the present study is to prepare and characterize Naga bhasma on structural and elemental basis to address the role of the raw materials used during the preparation, compound form of the lead bhasma, nature (crystalline/amorphous) and crystallite/particle size of the drug. The study also covers the toxicological effect of the drug on albino rats. It was found that drug contains lead in nano-crystalline (∼60 nm) lead sulfide form (Pb2+) associated with the organic contents and different nutrient elements coming from the herbs used during the preparation. Naga bhasma prepared was found to be totally safe in histopathology study on rats at a dose of 6 mg/100 g/day. The different characterization techniques used present a role model for the quality control and standardization of such kinds of herbo-metallic medicines.