Browsing by Author "Debasis Bagchi"

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A Review on Diverse Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics
(Elsevier, 2024) Debasis Bagchi; Rameshwar Nath Chaurasia; Sunny E. Ohia
A Review of Diverse Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics offers an unparalleled compilation of the current understanding of neurodegenerative disorders. This book investigates the origins of mental disorders, encompassing bacterial and fungal invasions, viral assaults, and genetic predispositions, providing readers with a thorough grasp of the neurological landscape. Each chapter dissects the intricacies of these incapacitating conditions, ranging from the pathogenesis of central nervous system tuberculosis to the involvement of endocannabinoids in rabies infection. Topics such as neuroinflammation, axonal pathology, and the intricate relationship between diet, gut microbiomes, and cognitive decline are also explored. This book conducts an extensive examination of neurodegeneration, incorporating discussions on the role of probiotics and natural bioactive compounds in preventing ailments such as Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS). With meticulous analyses of vitamins, micronutrients, antioxidants, and nutraceuticals, this work offers a roadmap for promoting neuroprotection. A Review of Diverse Neurological Disorders serves as a resource that not only reviews the current understanding but also lays the groundwork for future treatments and innovations. © 2024 by Elsevier Inc. All rights reserved, including those for text and data mining, AI training, and similar technologies.
Antioxidants and functional foods for neurodegenerative disorders: Uses in prevention and therapy
(CRC Press, 2021) Abhai Kumar; Debasis Bagchi
Neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are a growing problem across the world's aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants - including vitamin D, tocotrienol and coenzyme Q10 - against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases. © 2021 Taylor & Francis Group, LLC. All rights reserved.
Commentary: A treatise on neurodegenerative disorders and protection by structurally diverse antioxidants and functional foods
(CRC Press, 2021) Abhai Kumar; Debasis Bagchi
The etiology of neurodegenerative disorders and its consequences has been demonstrated due to continuous and progressive loss of brain cells, preceding to the dysfunctions and degeneration of the neuronal functions and nervous system. In global scenario, World Health Organization reports that diverse neurological disorders and brain injuries, including Parkinson's disease, Alzheimer's disease, epilepsy, neuronal infections, multiple sclerosis, and stroke, affect about one billion people worldwide. The proceeding of advancing age-induced neurodegeneration is a progressive deterioration of neuronal cells, its structural integrity, and functions, which eventually steer to cognitive disability and dysfunctions, and dementia. Generally, neurodegenerative disorders and dysfunctions strike primarily in the middle and advancing age populations, and this prevalence is growing up remarkably in aged population. Selected structurally diverse antioxidants, standardized botanical extracts, and nutraceuticals enriched in phytonutrients and antioxidants have been extensively demonstrated to inhibit these critical inflammatory elements and rectify the vital oxidant/antioxidant imbalance in humans suffering from diverse neurodegenerative disorders. © 2021 Taylor & Francis Group, LLC. All rights reserved.
Preface
(CRC Press, 2021) Abhai Kumar; Debasis Bagchi
[No abstract available]