Browsing by Author "Deepak Chandran"

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Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential
(Frontiers Media S.A., 2022) Saikat Mitra; Rajib Das; Talha Bin Emran; Rafiuddin Khan Labib; Noor-E-Tabassum; Fahadul Islam; Rohit Sharma; Islamudin Ahmad; Firzan Nainu; Kumarappan Chidambaram; Fahad A. Alhumaydhi; Deepak Chandran; Raffaele Capasso; Polrat Wilairatana
Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in a solid mass of cells known as a tumor or liquid cancer. It is the leading cause of mortality worldwide, and the number of cancer patients has been increasing at an alarming rate, with an estimated 20 million cases expected by 2030. Thus, the use of complementary or alternative therapeutic techniques that can help prevent cancer has been the subject of increased attention. Garlic, the most widely used plant medicinal product, exhibits a wide spectrum of biological activities, including antibacterial, hypo-lipidemic, antithrombotic, and anticancer effects. Diallyl disulfide (DADS) is a major organosulfur compound contained within garlic. Recently, several experimental studies have demonstrated that DADS exhibits anti-tumor activity against many types of tumor cells, including gynecological cancers (cervical cancer, ovarian cancer), hematological cancers (leukemia, lymphoma), lung cancer, neural cancer, skin cancer, prostate cancer, gastrointestinal tract and associated cancers (esophageal cancer, gastric cancer, colorectal cancer), hepatocellular cancer cell line, etc. The mechanisms behind the anticancer action of DADS include epithelial-mesenchymal transition (EMT), invasion, and migration. This article aims to review the available information regarding the anti-cancer potential of DADS, as well as summarize its mechanisms of action, bioavailability, and pharmacokinetics from published clinical and toxicity studies. Copyright © 2022 Mitra, Das, Emran, Labib, Noor-E-Tabassum, Islam, Sharma, Ahmad, Nainu, Chidambaram, Alhumaydhi, Chandran, Capasso and Wilairatana.
Dryland Livestock Rearing Relies Heavily on Tree fodders: A Narrative Review
(Indian Veterinary Assocaition, 2022) A. Manuvanthra; Deepak Chandran; Talha Bin Emran; Muhammad M.K. Aslam; Vishnu V. Savanth; Manoj Kumar; Rohit Sharma; Luiz Everson da Silva; M. Pran; N.P. Lishma; R. Sureshkumar
Forage crops that are easy to maintain, more effective, drought tolerant, and supportive of dryland agriculture in arid and semi-arid areas of the world are now more likely to be prioritized. Dryland agriculture benefits from the unique characteristics of tree fodders such as it’s deeper root structure, low water requirement, and capacity to endure harsh climates. Additionally, the quality of the feed provided by fodder trees has been determined to be more nutritious than those received from other sources. It is also crucial that these fodder trees continue to supply the cattle with fodder even if other crops are impacted by drought and water constraint. This review paper provides significant information upon various important tree fodders that could be used for livestock rearing in dryland areas. © 2022 Indian Veterinary Assocaition. All rights reserved.
Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets
(Frontiers Media S.A., 2022) Mumtaza Mumu; Ayan Das; Talha Bin Emran; Saikat Mitra; Fahadul Islam; Arpita Roy; Md. Mobarak Karim; Rajib Das; Moon Nyeo Park; Deepak Chandran; Rohit Sharma; Mayeen Uddin Khandaker; Abubakr M. Idris; Bonglee Kim
Fucoxanthin (FX) is a special carotenoid having an allenic bond in its structure. FX is extracted from a variety of algae and edible seaweeds. It has been proved to contain numerous health benefits and preventive effects against diseases like diabetes, obesity, liver cirrhosis, malignant cancer, etc. Thus, FX can be used as a potent source of both pharmacological and nutritional ingredient to prevent infectious diseases. In this review, we gathered the information regarding the current findings on antimicrobial, antioxidant, anti-inflammatory, skin protective, anti-obesity, antidiabetic, hepatoprotective, and other properties of FX including its bioavailability and stability characteristics. This review aims to assist further biochemical studies in order to develop further pharmaceutical assets and nutritional products in combination with FX and its various metabolites. Copyright © 2022 Mumu, Das, Emran, Mitra, Islam, Roy, Karim, Das, Park, Chandran, Sharma, Khandaker, Idris and Kim.
Garlic (Allium sativum L.) bioactives and its role in alleviating oral pathologies
(MDPI, 2021) Minnu Sasi; Sandeep Kumar; Manoj Kumar; Sandhya Thapa; Uma Prajapati; Yamini Tak; Sushil Changan; Vivek Saurabh; Shweta Kumari; Ashok Kumar; Muzaffar Hasan; Deepak Chandran; Radha; Sneh Punia Bangar; Sangram Dhumal; Marisennayya Senapathy; Anitha Thiyagarajan; Ahmad Alhariri; Abhijit Dey; Surinder Singh; Suraj Prakash; Ravi Pandiselvam; Mohamed Mekhemar
Garlic (Allium sativa L.) is a bulbous flowering plant belongs to the family of Amaryllida-ceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Integrated management of Fusarium wilt disease of banana in Kerala, India
(Springer, 2024) N.P. Lishma; K. Anita Cherian; Vimi Louis; R. Sureshkumar; P. Naveen Kumar; Deepak Chandran; M. Pran; Rohit Sharma
Banana is considered an important fruit crop in the livelihood of many people in tropical and subtropical countries. However, in India, the banana crop is threatened by Fusarium wilt disease incited by the pathogen Fusarium oxysporum f. sp. cubense (Foc), a soil-borne fungus. A purposive sampling survey was conducted in 2018 in various districts of Kerala to study the extent of disease incidence and its severity. The study revealed that the disease incidence ranged from 1.52 to 43.65 percent with 20.41 to 49.57 percent severity. During the survey, it was observed that the major cultivating varieties such as Rasthali/Poovan, Kadali, Njalipoovan, and Chenkadali were infected by the disease which causes serious economic loss to the farmers. Hence, the research was carried out to create an integrated management package against the pathogen causing Fusarium wilt disease in bananas by testing various chemical fungicides and biocontrol agents under both as well as field conditions. Among the various treatments used, an integrated package including sucker treatment with biocontrol agent Pseudomonas fluorescens followed by the soil application of Arbuscular Mycorrhizal Fungi and Trichoderma viride (biocontrol agent) enriched cow dung at the time of planting and soil drenching with a triazole fungicide tebuconazole at 2 and 4 months after planting was recorded best for the disease management. As a result, the management of Fusarium wilt of banana may be accomplished by the employment of a combined strategy of biocontrol agents and chemical fungicides applied at the prescribed rate. © The Author(s) under exclusive licence to Society for Plant Research 2023.
Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
(MDPI, 2022) Talha Bin Emran; Fahadul Islam; Saikat Mitra; Shyamjit Paul; Nikhil Nath; Zidan Khan; Rajib Das; Deepak Chandran; Rohit Sharma; Clara Mariana Gonçalves Lima; Ahmed Abdullah Al Awadh; Ibrahim Abdullah Almazni; Abdulaziz Hassan Alhasaniah; Raquel P. F. Guiné
Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing long-term chronic diseases like diabetes and heart disease is an important role of dietary carbohydrates. Colon and breast cancer are among the diseases for which data suggest that modified pectin (MP), specifically modified citrus pectin (MCP), has beneficial effects on the development and spread of malignancies, in addition to its benefits as a soluble dietary fiber. Cellular and animal studies and human clinical trials have provided corroborating data. Although pectin has many diverse functional qualities, this review focuses on various modifications used to develop MP and its benefits for cancer prevention, bioavailability, clinical trials, and toxicity studies. This review concludes that pectin has anti-cancer characteristics that have been found to inhibit tumor development and proliferation in a wide variety of cancer cells. Nevertheless, further clinical and basic research is required to confirm the chemopreventive or therapeutic role of specific dietary carbohydrate molecules. © 2022 by the authors.
Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential
(Hindawi Limited, 2022) Saikat Mitra; Maniza Muni; Nusrat Jahan Shawon; Rajib Das; Talha Bin Emran; Rohit Sharma; Deepak Chandran; Fahadul Islam; Md. Jamal Hossain; Sher Zaman Safi; Sherouk Hussein Sweilam
Tacrine is a drug used in the treatment of Alzheimer's disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (AChE). However, its clinical application has been restricted due to its poor therapeutic efficacy and high prevalence of detrimental effects. An attempt was made to understand the molecular mechanisms that underlie tacrine and its analogues influence over neurotherapeutic activity by focusing on modulation of neurogenesis, neuroinflammation, endoplasmic reticulum stress, apoptosis, and regulatory role in gene and protein expression, energy metabolism, Ca2+ homeostasis modulation, and osmotic regulation. Regardless of this, analogues of tacrine are considered as a model inhibitor of cholinesterase in the therapy of Alzheimer's disease. The variety both in structural make-up and biological functions of these substances is the main appeal for researchers' interest in them. A new paradigm for treating neurological diseases is presented in this review, which includes treatment strategies for Alzheimer's disease, as well as other neurological disorders like Parkinson's disease and the synthesis and biological properties of newly identified versatile tacrine analogues and hybrids. We have also shown that these analogues may have therapeutic promise in the treatment of neurological diseases in a variety of experimental systems. © 2022 Saikat Mitra et al.