Browsing by Author "Deepak Gautam"

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An overview of human health risk from opium alkaloids and related pharmaceutical products pollution in aquatic ecosystems
(Elsevier, 2022) Sonam; Markandeya; Y. Shiv Shankar; Prashant Bhushan; Deepak Gautam; Pankaj Kumar; S.P. Shukla; Devendra Mohan
Fresh water is a valuable resource, but the increase in pollution of aquatic ecosystem is a matter of concern. Industries are rapidly budding in India, which discharge their effluents into the water bodies either directly or after treating partially. Pharmaceutical compounds are very important, but at the same time, release toxic contaminants in the environment. Pharmaceutical products impose huge effects on aquatic environment, resulting in acute and chronic damages, reproductive damage, behavioral changes, and inhibition of cell proliferation. The effluents produced from alkaloid processing industries is highly polluted having low pH, high COD, BOD5, sulfate, and TKN values, and a characteristic dark brown color. A number of physical as well as biological processes occurring in aquatic ecological unit may cause reduction of trace concentrations of pharmaceutical compounds. Treatment of wastewater generated from alkaloid processing is a challenging task because of the complex mixture of contaminants. Several methods for the treatment of these wastes, such as anaerobic and aerobic biological treatment, anaerobic treatment with membrane treatment, and aerobic treatment with catalytic wet air oxidation have been reported. Studies have also been conducted on physicochemical treatment in combination with activated sludge process. Membrane processes and Fenton oxidation have also been investigated as a post-treatment method. Membrane technologies are desirable for industrial wastewater treatment as no external addition of chemicals is required. © 2022 Elsevier Inc. All rights reserved.
Masseter muscle cysticercosis: A common disease with uncommon presentation
(2013) Rameshwar Nath Chaurasia; Shalini Jaiswal; Deepak Gautam; Vijay Nath Mishra
Cysticercosis in humans is caused by Taenia solium larvae infestation. Oral cysticercosis is a rare condition and is challenging to diagnose. We present a case of masseter cysticercosis in a young woman who presented with painful recurrent cheek swelling. Diagnosis confirmed it after neuroimaging and histopathological examination of the excised lesion from masseter muscle. Copyright 2013 BMJ Publishing Group. All rights reserved.
Morvan’s syndrome—is a pathogen behind the curtain?
(Springer-Verlag Italia s.r.l., 2018) Rohit Singh; Pritam Das; Upinder Kaur; Anamika Misra; Ashis Choudhury; Sukdev Manna; Rohit Gaude; Deepak Gautam; Indrajeet Singh Gambhir; Sankha Shubhra Chakrabarti
Morvan’s syndrome is a rare syndrome of likely autoimmune etiology characterized by peripheral nerve hyperexcitability, dysautonomia, insomnia, and fluctuating delirium with prominent hallucinations. Since its first mention in 1890, less than 100 cases have been described in literature. The largest existing review includes details of 29 cases. This case series describes 4 cases (M = 4) of Morvan’s syndrome which presented between May and November 2017 to a single tertiary care referral teaching hospital in north India. All the four patients manifested behavioral abnormalities, sleep disturbances, hallucinations, autonomic dysfunction, and clinical signs of peripheral nerve hyperexcitability, mostly as myokymia. Two of the patients had Anti-CASPR2 (contactin-associated protein 2) antibodies. Three of them had electromyography features of peripheral nerve hyperexcitability and only one had elevated cerebrospinal fluid protein level. We hypothesize that Morvan’s syndrome and other less characterized autoimmune encephalitis/peripheral nervous system syndromes may have infectious triggers. A possible viral trigger may result in generation of autoantibodies which result in the typical manifestations. We base these hypotheses on the finding of four cases of an orphan disease within a short period of time in a limited geographical distribution. © 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.
Philadelphia chromosome- positive myelodysplastic syndrome with single lineage dysplasia
(Elsevier Inc., 2023) Ajeet Kumar; Vijai Tilak; Disha Arora; Marisha; Rahul; Deepak Gautam; Akhtar Ali
Myelodysplastic syndrome (MDS) is a group of acquired clonal disorders characterized by dysplastic and ineffective hematopoiesis in the bone marrow. Various specific karyotypic and molecular abnormalities associated with MDS further guide the prognosis. Although translocation t(9;22)(q34;q11) (Philadelphia positive [Ph+]) and corresponding BCR-ABL fusion transcript are classically defined to differentiate CML from non-CML myeloproliferative disorders, it is also associated with adult acute lymphoblastic leukemia (Ph+ ALL), acute myeloid Leukemia (Ph+ AML), myelodysplastic syndrome (Ph+ MDS). The occurrence of Ph+ MDS is very uncommon, and a review of literature has shown by far 40 cases so far in which the majority are seen on progression to Leukemia. Few had de novo presence of such chromosomal abnormality. Due to its rarity, this entity has not yet found its space in the current WHO classification. Also, the role of tyrosine kinase inhibitors in such a scenario is still debatable. We found two such cases of de novo Ph+ MDS diagnosed at institute of medical sciences, Banaras Hindu university and a brief literature review. © 2023