Browsing by Author "Deepak Kotiya"

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Probiotics for Management of Gastrointestinal Cancers
(Springer Singapore, 2020) Nilesh Rai; Anurag Kumar Singh; Priyanka Kumari Keshri; Suvakanta Barik; Swapnil C. Kamble; Santosh Kumar Singh; Rajiv Kumar; Pradeep Mishra; Deepak Kotiya; Vibhav Gautam
Probiotics has been used for management of genetically predisposed health disorders associated with gastrointestinal (GI) tract. Administration of specific probiotics in defined doses causes revitalization of healthy gut microflora that can positively modulate immune response within GI tract and hence, aid in the management of inflammation of intestinal mucosa. Thus, it has potential of becoming a durable therapeutic approach to resolve metabolism related disorders including GI cancers. Probiotic-induced competition can exclude and replace pathogenic microorganisms from GI cancer-induced niche in gut. Notably, oral administration of probiotics is a key driving factor for the ease of management of post-operative complications of GI tract cancers. Here, we attempt to summarize the diversified knowledge of probiotics to utilize as therapeutic tool in prevention, progression and treatment of GI tract cancer, current challenges of probiotics in regulating GI cancer progression, and future perspectives. © Springer Nature Singapore Pte Ltd. 2021, corrected publication 2021.
Recent technological advancements in stem cell research for targeted therapeutics
(Springer, 2020) Nilesh Rai; Anurag Kumar Singh; Santosh Kumar Singh; Bhaskar Gaurishankar; Swapnil C. Kamble; Pradeep Mishra; Deepak Kotiya; Suvakanta Barik; Neelam Atri; Vibhav Gautam
Stem cells have characteristic features of self-renewal, pluripotency and differentiation, which are responsible for replenishment of tissue or organ. Stem cells are potentiated as therapeutic tool in drug targeting and regenerative medicine—from curing various neurological diseases and malignancies to congenital diseases. These technological advancements have established stem cells as future of medicine. However, due to ethico-social limitations, the use of embryonic stem cells (ESCs) has been avoided, while physiological availability of adult stem cells (ASCs) and induced pluripotent stem cells (iPSCs) has gained appropriate preference. These iPSCs are very much similar to ESCs in terms of their self-renewal and pluripotency. Here, we have summarized the technologies that have established stem cells isolation, their molecular marker and factors responsible for their maintenance. Different cellular (transcription factors, regulatory proteins, miRNA like miRNA-296, miRNA-145, etc.) and extracellular components transcend stem cell fate. Their identification and characterization involve development and efficient utilization of tools like magnetic activated cell sorting (MACS) and fluorescence activated cell sorting (FACS). Some of the technologies have been patented and spin-off’s based on them have been commercialized. In conclusion, we present the future scope and possibilities that stem cell technologies behold for us. [Figure not available: see fulltext.]. © 2020, Controlled Release Society.