Browsing by Author "Deepak Maurya"

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Gravity magnetic appraisal of the SandurSuperTerrane, Dharwar Craton, India for Shallow crustal architecture and mineralization
(European Association of Geoscientists and Engineers, EAGE, 2023) Deepak Maurya; S.S. Ganguli; Payal Rani
We are presenting detailed analysis of ground gravity and magnetic data over the Sandur Super Terrane (SST) of Eastern Dharwar craton (EDC), India. The SST holds a unique position amongst the other schist belt of Dharwar Craton as it is located within the Closepet granite complex and the same time, the terrane preserves of lithologies common to both EDC and WDC. We have applied integrated approach to correlate the geophysical signature with the available geological information. The Sandur Schist belt and adjacent schist belts are represented by gravity high anomalies and high amplitude analytical signal (AS) indicating presence of mafic-ultramafic rocks along the schist belt. Gravity low are observed over granites and moderate anomalies observed over gneisses. The study shows the prominent litho-units have distinct potential field signature which enable us to reveal continuity of the different litho-units. Joint gravity-magnetic modelling suggests schist belt represent a basin like structure and has depth extension of ~6km. The gneisses in south western part of the Sandur Schist Belt are less magnetic in nature. We have observed that reported manganese, iron and gold mineralization are associated with high amplitude AS signal and gravity high anomalies. The observation allows to curve out the areas for further exploration as we have delineated another arm of the schist belt from the present study. The petro-physical studies indicates that densities of mafic-ultramafic rocks ranges from 2,860-3,560 Kg m-3 and susceptibilities ranges from 561 - 4056 (*10-6 CGS units). © 2023 2nd EAGE/Aqua Foundation Indian Near Surface Geophysics Conference and Exhibition. All rights reserved.
One-Step Room Temperature Synthesis of Printable Carbon Quantum Dots Ink for Visual Encryption and High-Performance Photodetector
(John Wiley and Sons Inc, 2024) Baishali Thakurta; Sobhan Hazra; Alapan Samanta; Adnan Nasir; Amresh Kumar Singh; Deepak Maurya; Bama Charan Mondal; Anupam Giri; Bhola Nath Pal; Monalisa Pal
Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic applications and have garnered much interest as potential competitors to conventional inorganic or hybrid semiconductor quantum dots because of carbon's intrinsic merits of high stability, low cost, and environment-friendliness. The ability of easy formulation of functional ink of CQDs is necessary for the development of industrial-scale, reliable, inexpensive printing/coating processes, for its full exploitation in the ever-growing class of applications in sensors, optoelectronics, and energy storage and conversion. Here a facile one-step room-temperature synthesis of printable, fluorescent CQD ink is demonstrated. The as-synthesized fluorescent CQD ink is used for invisible fingerprint stamps, printing of micro-patterns, and soft lithographic patterning with a resolution down to 1.5 µm. This functional CQD ink is also used to fabricate a high-performance CQD-ZnO heterojunction ultraviolet (UV) photodetector with a photo-responsivity of 3.85 A W−1, detectivity of 6.78 × 1010 Jones, and an external quantum efficiency (EQE) of 15.3%. The enhanced device performance can be attributed to CQD's high photocurrent generation efficiency and rational combination of the asymmetric electrode materials. This work enables a high-temperature stable CQD fluorescent ink synthesis method to fulfill the processing requirements of printing and soft lithographic patterning for visual encryption and optoelectronics. © 2024 Wiley-VCH GmbH.
Protocol to study DNA strand breaks during development and apoptosis using in situ nick translation in Drosophila
(Cell Press, 2025) Deepak Maurya; Bama Charan Mondal
Cellular stress causes DNA strand breaks that are typically repaired to maintain homeostasis and regulate cell fate. However, unrepaired DNA breaks can be lethal, leading to cell death. Here, we present a protocol to study DNA strand breaks in Drosophila during development and apoptosis using in situ nick translation. We describe the steps for labeling DNA strand breaks using digoxigenin (DIG)-labeled nucleotide (DIG-11-dUTP) and visualizing them with anti-DIG immunostaining. We then detail procedures for mounting, imaging, and analysis. For complete details on the use and execution of this protocol, please refer to Maurya et al.1 and Rigby et al.2 © 2025 The Authors
Transient caspase-mediated activation of caspase-activated DNase causes DNA damage required for phagocytic macrophage differentiation
(Elsevier B.V., 2024) Deepak Maurya; Gayatri Rai; Debleena Mandal; Bama Charan Mondal
Phagocytic macrophages are crucial for innate immunity and tissue homeostasis. Most tissue-resident macrophages develop from embryonic precursors that populate every organ before birth to lifelong self-renew. However, the mechanisms for versatile macrophage differentiation remain unknown. Here, we use in vivo genetic and cell biological analysis of the Drosophila larval hematopoietic organ, the lymph gland that produces macrophages. We show that the developmentally regulated transient activation of caspase-activated DNase (CAD)-mediated DNA strand breaks in intermediate progenitors is essential for macrophage differentiation. Insulin receptor-mediated PI3K/Akt signaling regulates the apoptosis signal-regulating kinase 1 (Ask1)/c-Jun kinase (JNK) axis to control sublethal levels of caspase activation, causing DNA strand breaks during macrophage development. Furthermore, caspase activity is also required for embryonic-origin macrophage development and efficient phagocytosis. Our study provides insights into developmental signaling and CAD-mediated DNA strand breaks associated with multifunctional and heterogeneous macrophage differentiation. © 2024 The Authors