Browsing by Author "Dev Nath Singh Gautam"

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Accelerated stability study and quantitative estimation of piperine in Draksharishta
(J. K. Welfare and Pharmascope Foundation, 2017) Vaibhav Tiwari; B.M.N. Kumar; Vineet Sharma; Dev Nath Singh Gautam
The objective of the present study was to evaluate the accelerated stability study and estimation of piperine from Draksharishta. Accelerated stability study was done for 6 months to distinguish the stabiIity of polyherba I formulation in reference to its physicochemical, phytoconstituents within. Asava and Arishta are self-generated herbal fermentations of traditional ayurvedic system. Draksharishta was prepared as per AFI part-l (The Ayurvedic formulary of India, part-1) using authenticated raw drugs. For accelerated stability study for six months period the prepared sample of Draksharishta was placed in the controlled situation following ICH (International Conference on Harmonization) guidelines. The intermediate sampling was done at initial, after 1, 3 and 6 months respectively. The organoleptic characters and physicochemical parameters of samples showed similar results to that sample at starting the month; it indicates that product was stable and having required stability. No significant variations in the value of alcohol content, acidity and sugar content of sample had been reported over 6-month storage. An only significant variation in the value of total phenolic content was observed. On the basis of this stability study, it could be said that this formulation was stable for the period of more than 24 months on the basis of arrhenius equation. ©JK Welfare & Pharmascope Foundation.
Acute toxicity study of white and black gunja pericarps (abrus precatorius)
(BRNSS Publication Hub, 2018) Dev Nath Singh Gautam
Aim: Abrus precatorius Linn. (Fabaceae) pericarps are used for the treatment of sciatica and alopecia which comprises the toxic protein and alkaloids, abrine, trigonelline, choline, and hypaphorine. Ayurveda urges the use of Abrus pericarps after the Shodhana process (detoxification). The current study was aimed at performing the Shodhana process, Swedana (boiling) of A. precatorius pericarps using cow’s milk, and Kanji (sour gruel) as a medium and to evaluate the acute toxicity of pericarps before and after detoxification in cow’s milk and Kanji. Materials and Methods: The acute toxicity study was carried out as per organization for economic cooperation and development guidelines 425. In acute toxicity study, the intraperitoneal dose (0.5, 1, and 2 mg/kg) of Ashodhita (unprocessed) and Shodhita (processed) white and black varieties of pericarps of A. precatorius was administered to 30 groups in a single dose, and general behavior, adverse effects, and mortality were determined up to 72 h. Results and Discussion: In acute toxicity, Ashodhita white and black varieties of pericarps of A. precatorius were found toxic, whereas neither mortality nor any significant alteration in behavior was observed in black varieties of pericarps of Shodhita A. precatorius, while some mortality and alteration in behavior were observed in white varieties of pericarps of Shodhita A. precatorius. Conclusion: The white varieties of pericarps are more toxic than black varieties of A. precatorius. It was also found that Shodhana in Kanji is more effective than cow’s milk. © 2018 BRNSS Publication Hub. All rights reserved.
Ayurvedic strategy to achieve sustainable development goal 3: Management of cancer (Arbuda)
(Nova Science Publishers, Inc., 2022) Anupriya Singh; Anjali Upadhyay; Jyoti Singh; Ambrish Kumar Singh; Dev Nath Singh Gautam; Narendra Kumar Singh
Cancer is the second leading cause of morbidity and mortality as well as growing health problems worldwide. Effective drugs and therapies are available for different kinds of cancer also having side effects; hence people seek relatively safer as well as cost-effective alternative and complementary medicines for the treatment of cancer. The objective of the present chapter is to provide Ayurvedic concept-based evidence for the treatment and management of cancer to the academician and researcher who garners interest in cancer. The present study provides comprehensive information about Arbuda (cancer) and its probable remedy through Ayurveda and fulfilling the Sustainable Development Goals (SDGs) that is SDG 3. Arbuda develops due to Mithya Ahar (unhealthy diet) and Mithya Vihar (unhealthy lifestyle) leading to imbalance in Vatadi Doshas (regulatory functional factors of the body) which leads to vitiation of Dhatus (major structural components of the body). Vitiated Dhatus results in the formation of muscular swelling anywhere in the body with the appearance of large, circular, immobile, less painful, slowly growing and deep-seated swelling such a clinical entity termed as Arbuda. Symptomatically, Arbuda may have a resemblance with clinical entities such as cancer. However, the exact pathogenesis of cancer does not match these two conditions, but still, it may be possibly correlated up to a certain extent. The involvement of one or two Doshas (Vata, Pitta and Kapha), produce benign neoplasm which is harmless but the association of all three Doshas (Sannipataja/Tridoshaja) produces malignant neoplasm, which is harmful. The term Dviarbuda (metastasis) and Adhyarbuda (recurrence) are considered Asadhya (incurable) and these two terminologies may be correlated to the metastatic growth of cancer cells. Management of Arbuda includes all those plants having Laghu, Ruksha and Tikshna Guna may possess Lekhana and Kaphashamak action. © 2022 Nova Science Publishers, Inc..
Consumption of Ashtanga Ghrita (clarified cow butter added with herb extracts) improves cognitive dysfunction induced by scopolamine in rats via regulation of acetylcholinesterase activity and oxidative stress
(De Gruyter Open Ltd, 2021) Vineet Sharma; Zeba Firdaus; Himanshu Rai; Prasanta Kumar Nayak; Tryambak Deo Singh; Dev Nath Singh Gautam
Objectives: Ashtanga Ghrita (AG), an Indian traditional formulation, has been used to promote neuropharmacological activities. AG is made up of clarified cow butter (ghee) and eight different herbs. Methods: To test whether scopolamine (SCP)-induced dementia and brain oxidative stress can be counteracted by AG, rats were separated into five groups (n=6/group): Group one control, group two SCP (1 mg/kg b.w., i.p.) treated and group three to five were co-treated with different doses of AG (1.25, 2.5 and 5 g/kg b.w., orally) and SCP. After the treatment regimen, behavioral (Y-maze test) and brain biochemical changes were measured in all groups. Results: Microbial load and heavy metals were found within permissible limits. Results from attenuated total reflection Fourier-transform infrared spectroscopy demonstrated the complexation/interaction of herbal phytoconstituents with the functional groups of Ghrita. Preliminary phytochemical analysis of AG exhibited the occurrence of flavonoids, phenolics, glycosides, steroids, triterpenes, tannins, and amino acids. Findings of the experimental study exhibited that AG significantly protected the rats from SCP-induced behavioral dysfunction and brain biochemical alterations. Conclusions: This study demonstrates that AG protects the brain from SCP-induced dementia by promoting brain antioxidant activity and thus could be a promising drug for the treatment of neurodegenerative disease. © 2021 Walter de Gruyter GmbH, Berlin/Boston.
Ethnomedicinal, toxicity and pharmacological study of Abrus precatorious: A critical review
(Research Journal of Pharmacy and Technology, 2017) Dev Nath Singh Gautam
In this review, an attempt has been made tocompile information related to the ethnomedicinal toxicity and pharmacological studies of Abrus precatorious. It is a perennial twining woody shrub belonging fabaceae family. The root, seeds, and leaves of A. precatorious are used worldwide for the treatment pain, swelling, leucoderma, stomatitis, wounds, gonorrhea, goiter, cervical lymph node, horseness of voice, purgative, emetic, alopecia sciatica. Major alkaloidal phytoconstituents reported from the roots, leaves, and seeds of A. precatorious include abrin, abralin, hypaphorine, choline which have been an investigated for a wide range of biological activities. In the toxicological investigation of A.precatorious,it was found that the seed powder of this plant produces toxicity like convulsions and irritation of the conjunctiva in many cases. Pharmacological activities of different parts of the plant reported include abortifacient, anti-fertility, anti-spermatogenic, antidiabetic, anti-malarial, antioxidant, anti-convulsant, antiepileptic, antitumor, nephroprotective and anti-inflammatory, activity. In the current review the literature data on the ethnomedicinal toxicity and pharmacological investigations on the A. precatorious are reviewed up to June 2017. © RJPT All right reserved.
Ethnopharmacology, Phytochemistry, and Pharmacology of Ashtanga Ghrita: an Ayurvedic Polyherbal Formulation for Neurological Disorders
(Springer Science and Business Media Deutschland GmbH, 2022) Jyoti Singh; Anupriya Singh; Vineet Sharma; Tryambak Deo Singh; Meenakshi Singh; Ruchika Garg; Rohit Sharma; Dev Nath Singh Gautam
Purpose of Review: Ayurveda is an ancient Indian medical system with unique approaches for the treatment of various brain disorders. Ashtanga Ghrita, a cow Ghrita-based polyherbal classical formulation, has been well defined in ancient Ayurvedic texts Ashtanga Hridya to enhance speech, intellect, and memory. The formulation contains eight potent neuroprotective herbs along with clarified cow butter and milk. The review is aimed to come up with comprehensive scientific evidence regarding the plant ingredients of Ashtanga Ghrita so that it can be used for further clinical studies as well as to treat a variety of neurological diseases. Recent Findings: The plant ingredients have been practiced since ancient times for various disorders in India as well as worldwide. The plants contain various phytochemicals including terpenes, steroids, glycosides, flavonoids, alkaloids, amino acids, fatty acids, aryl esters, and carbohydrates. The collected pharmacological evidence suggests that all the plant ingredients have neuroprotective, anxiolytic, antidepressant, antioxidant, immunomodulatory, sedative, antiproliferative, and anticonvulsant activity. Summary: Based on the collected evidence, Ashtanga Ghrita may prove to be an effective neuroprotective drug and might be useful in various neurological disorders. Further, well-designed multicentric clinical trials are required to elucidate and comprehend the therapeutic potential of the formulation. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Ethnopharmacology, phytochemistry, and pharmacology of Polygonum glabrum Willd
(BRNSS Publication Hub, 2017) Vineet Sharma; Dev Nath Singh Gautam
The current paper reviewed the ethnomedicinal uses, phytochemistry, and pharmacology of Polygonum glabrum willd. belonging to family Polygonaceae. All the available information on the traditional uses, phytochemistry, and pharmacology of P. glabrum was gathered through a library and electronic searches in Google Scholar, PubMed, Science Direct, and SciFinder for the period, 1886-2016. The plant P. glabrum was usually known as Rasna found almost in all parts of India ascending to an altitude of 1900 m from the sea level. P. glabrum is an important medicinal plant in the Indian system of medicine (Ayurveda). This plant is used by ethnic groups for the treatment of pain, jaundice, piles, pneumonia, burn, wound, etc. Major phytochemical compounds reported from the leaves and aerial parts of P. glabrum belong to sesquiterpenoids, flavonoids, and sterol which have a wide range of biological activities. Pharmacological activities reported for the plant P. glabrum are anti-inflammatory, analgesic, antifungal, antibacterial, antidepressant, hepatoprotective, antioxidant, antimalarial, nephroprotective, anti-HIV, antidiabetic, and antiproliferative activity. Present available information revealed that more than 27 compounds isolated from the different plant parts of P. glabrum. Most of the compounds isolated from the leaves and aerial part of P. glabrum belong to flavonoids category which has a wide range of biological activities. Clinical study of isolated compounds may be performed to get prospective candidates for the treatment of cancer, liver disorders, malaria, and cardiovascular, neurological, and renal diseases.
Physicochemical and acute toxicity study of gunja (Abrus precatorius) pericarp
(Research Journal of Pharmacy and Technology, 2018) Dev Nath Singh Gautam
The aim of the present research work was to carry out the effect of Shodhana on Gunja pericarps by using advanced analytical tools and acute toxicity study. Abrus precatorius Linn (Fabaceae), is used widely in different Ayurvedic formulations with enormous therapeutic importance. The red varieties of Gunja seed’s pericarps were subjected to Swedana in cow’s milk and Kanji. The Ashodhita and Shodhita red Gunja pericarps were subjected to physicochemical and acute toxicity study. For the establishment of the effect of Shodhana, the percentage of total ash, acid insoluble ash, total protein and successive extractives were carried out on Ashodhita and Shodhita red Gunja pericarps. The acute toxicity study was carried out as per Organization for Economic Co-operation and Development guidelines 423. In acute toxicity study, the intraperitoneal dose of Ashodhita (unpurified) and Shodhita (purified) red pericarps of Gunja was administered to in a single dose and general behavior, adverse effects, and mortality were determined up to 72 h. The study showed that the percentage of total ash was reduced in Shodhita samples as compared to Ashodhita samples. The percentage of alcohol and water-soluble extractives in milk Shodhita pericarps were increased in all the samples, however, no significant variations were observed in Kanji Shodhita samples. In acute toxicity, Ashodhita red varieties of the pericarp of Gunja were found toxic whereas neither mortality nor any significant alteration in behavior was observed in the pericarp of milk and Kanji Shodhita Gunja. The study showed that Shodhana in Kanji is more effective. © RJPT All right reserved.
Pongamol from the seeds of Tephrosia purpurea exert anti-cancer activity against cervical cancer cell line
(National Institute of Science Communication and Policy Research, 2023) Snehal Kumari; Neha Chaudhary; Khushbu Priya; Geeta Rai; Dev Nath Singh Gautam; Narendra Kumar Singh
Tephrosia purpurea belongs to the family Fabaceae, is used for the treatment of inflammation, diabetes, cancer, chronic fever, boils, gingivitis etc. In the present study, three compounds (TP-1, TP-3 and TP-5) were isolated from ethyl acetate extract of the seeds of T. purpurea (EETP). Quantity of TP-3 (6.05%) in EETP was determined by HPLC. In-vitro anti-cancer activity of EETP and isolated compound TP-3 on SiHa cells as well as PBMCs (peripheral blood mononuclear cells) were evaluated by MTT (3-(4,5-di methyl thiazol-2-yl)-2,5-di phenyl tetrazolium bromide) assay. On the basis of spectroscopic analysis and physical properties, structure of isolated compounds TP-1, TP-3 and TP-5 were characterized as teclenone, pongamol and β-sitosterol respectively. Isolated compound TP-3 showed cytotoxicity against SiHa cells with the IC50 33.06 µgmL-1. TP-3 showed significant cytotoxicity at the concentration range from 20-50 µgmL-1 as compared to control. Maximum cytotoxicity (72.75%) was observed at the concentration of 50 µgmL-1. TP-3 showed non-significant cytotoxicity against PBMCs cells at all the concentrations except at 50 µgmL-1 (cytotoxicity 24.19%). EETP showed significant cytotoxicity (IC50 value 113.63 µgmL-1) against SiHa cells at the concentration range from 75-150 µgmL-1 as compared to control. Maximum cytotoxicity (75.34%) was observed at the concentration of 150 µgmL-1. © 2023, National Institute of Science Communication and Policy Research. All rights reserved.
Purification of Guggul by Ayurvedic process (Shodhana), estimation of guggulsterone E & Z before and after purification by HPLC analysis
(National Institute of Science Communication and Information Resources (NISCAIR), 2018) Prince Kumar Pal; Goli Penchala Prasad; Gajji Babu; Dev Nath Singh Gautam; Narendra Kumar Singh
Guggul is one of the Ayurvedic product in great demand, used for over thousands of years and high status for its versatile use in several ailments. The two most important pharmacological properties of guggul are its anti-inflammatory and hypolipidaemic actions. The present study was undertaken to find out the effect of three different media of purification (water, cow’s urine and Triphala Kashaya (decoction of three myrobalans)) of raw guggul on its markers Guggulsterone E & Z at different heating temperature during Shodhana (purification) process. The guggul purified by different methods was found to be quite variable in reference to physico-chemical parameters and its marker compounds Guggulsterone E & Z by HPLC analysis at similar chromatographic conditions. The Guggulsterone E & Z was found in the order: water > cow’s urine > Triphla Kashaya (0.29 w/w, 0.24 w/w and 0.16 w/w, respectively at 85 °C to 95 °C). But the same raw guggul purified with same media like water, cow’s urine and Triphala Kashaya at temperature 60 °C to 70 °C showed the presence of high quantity of Guggulsterone E & Z (0.49 w/w, 0.45 w/w and 0.30 w/w for water, cow’s urine and Triphala Kashaya, respectively), as compared to the quantity of Guggulsterone E & Z found at temperature 85 °C to 95 °C. © 2018, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.
Reviewing the Traditional/Modern Uses, Phytochemistry, Essential Oils/Extracts and Pharmacology of Embelia ribes Burm.
(MDPI, 2022) Vineet Sharma; Dev Nath Singh Gautam; Andrei-Flavius Radu; Tapan Behl; Simona Gabriela Bungau; Cosmin Mihai Vesa
Objectives: Embelia ribes Burm. (E. ribes, Myrsinaceae), also known as Vidanga in Ayurveda, has been shown to have significant therapeutic benefits on several disorders, and its main chemical bioactive constituent, embelin, has the therapeutic potential to be converted into innovative drugs, which is why it has recently received considerable interest. In the present work, we provide a higher level of comprehension, awareness, and extensive knowledge of the traditional uses, phytochemistry, and pharmacological characteristics of E. ribes throughout the last several decades (February 1965 to June 2021), emphasizing the importance of the study of essential oils extracted from E. ribes, which show a major potential for exerting antioxidant and anti-inflammatory activity. Materials and Methods: Google Scholar, MEDLINE, EMBASE, Scifinder, Scopus, and ScienceDirect were used to conduct a thorough literature search. Results: E. ribes is high in essential oils, alkaloids, flavonoids, steroids, and phenolics, all of which have medicinal benefits. The essential oils/extracts and isolated chemical constituents exhibited antioxidant activity, wound healing, antidiabetic, central nervous system (CNS)-related disease, antiviral, antiobesity, cardioprotective, antifungal, antibacterial, and antifertility activity, among other promising pharmacological effects. Conclusion: The translation between traditional applications and modern medicine may make E. ribes a promising target for the implementation of innovative medication. To investigate the efficacy and safety profile of E. ribes, further high-quality preclinical studies using advanced methodologies are required. © 2022 by the authors.
Role of Aparajita (Clitorea ternatea Linn.) in Cancer Prevention and Therapy: Evidence from Ethnomedicine, Phytochemistry and Pharmacology
(Informatics Publishing Limited, 2025) Jyoti K. Singh; Dev Nath Singh Gautam; Simant Sourav; Priyanka; Rohit Sharma
Clitorea ternatea Linn. (C. ternatea), native to tropical Asia, is commonly referred to as “Aparajita,” “blue pea,” “darwin pea,” “Asian pigeon wings,” “cordofan pea,” “conch flower,” and “blue bellvine. “In the context of Ayurvedic practice, it is utilised to enhance intellectual capacity and memory, treat dermatological conditions, and exhibits both anti-inflammatory and detoxifying effects. C. ternatea is rich in various phytochemicals, such as quercetin, kaempferol, myricetin glycosides, and anthocyanins. Herbal medicines and their phytochemical constituents are increasingly recognised as complementary interventions in cancer therapy. Consequently, this study sought to examine the anticancer potential of C. ternatea. This detailed report investigates the ethnomedicinal applications, phytochemical composition, nutritional benefits, and pharmacotherapeutic potential of this plant by conducting an exhaustive review of databases such as Embase, PubMed, SinoMed, and the China National Knowledge Infrastructure. Encompassed within are essential nutrients, including calcium, iron, proteins, and vitamins, as well as a variety of antioxidants such as flavonoids, phenols, and carotenoids. In addition, it exhibits properties that are antibacterial, anti-inflammatory, antispasmodic, antioxidant, anticancer, and antidiabetic. In addition, studies have shown that the plant’s bioactive constituents exhibit antioxidative, anti-inflammatory, and antiproliferative effects, which serve to impede the development of cancer cells. This literature review explores the mechanisms and signalling pathways linked to the diverse phytoconstituents of C. ternatea. It delves into safety issues, examines potential drug-drug interactions, and evaluates the influence of these phytoconstituents on the proliferation of cancer cells in various experimental settings. © 2025, Informatics Publishing Limited. All rights reserved.
Role of Moringa oleifera Lam. in cancer: Phytochemistry and pharmacological insights
(John Wiley and Sons Inc, 2023) Jyoti Singh; Dev Nath Singh Gautam; Simant Sourav; Rohit Sharma
Moringa oleifera Lam. (M. oleifera), aka “Shigru,” “mother's best friend,” “miracle tree,” “horseradish tree,” “drumstick tree,” and “oil tree,” native of the sub-Himalayan region of northern India, belongs to the Moringaceae family. The high nutritional value of M. oleifera makes it suitable for both nutritional and medicinal purposes. Because of its chemical constituents, M. oleifera is used to treat and combat malnutrition, especially in infants and nursing mothers. These days, herbal medicine and its phytocompound derivatives are also being recognized as effective complementary therapies for cancer treatment. So, in this study, M. oleifera is reviewed for its anticancer property. By thoroughly scanning the PubMed, Embase, SinoMed, and China National Knowledge Infrastructure databases, an extensive up-to-date report on its ethnomedicinal use, nutritional, phytochemistry, and pharmacotherapeutic potential is done. It has valuable nutrients such as vitamins, proteins, iron, calcium, antioxidants (flavonoids, carotenoids, and phenols) and ascorbic acid. Additionally, it is used as an antioxidant, anti-inflammatory, antispasmodic, antimicrobial, anticancer, and antidiabetic agent. There are also concrete evidence that this plant's bioactive constituents, numerous extracts have a high biopotential in a number of cancer cells, through its antioxidative, anti-inflammatory, antiproliferative, and cell cycle arresting properties. This extensive literature review will provide insights into several mechanisms and signaling pathways of its various phytoconstituents that can mitigate the growth of cancer cells in various experimental models, safety and toxicity concerns, and drug–drug interactions. © 2022 The Authors. Food Frontiers published by John Wiley & Sons Australia, Ltd and Nanchang University, Northwest University, Jiangsu University, Zhejiang University, Fujian Agriculture and Forestry University.
Screening of anti-cancerous potential of classical Raudra rasa and modified Raudra rasa modified with hiraka bhasma (nanodiamond) through FTIR & LC-MS analysis
(De Gruyter Open Ltd, 2022) Manoj Kumar Dash; Namrata Joshi; Vd. Sushil Dubey; Kamal Nayan Dwivedi; Dev Nath Singh Gautam
Objectives: Raudra rasa is an ayurvedic medicine explicitly prescribed for the treatment of arbuda (cancer), whereas hiraka bhasma has the potential to promote cancer healing properties. Together, these two medicines provide multifunction benefits. This paper analyses the functional groups of Raudra rasa modified with hiraka bhasma and compares it with the classically prepared raudra rasa. To identify the functional group, organic ligands, and active compounds present in samples of raudra rasa (CRR) and modified raudra rasa with hiraka bhasma (MRR) contributing to cancer alleviation by using Fourier transform infrared spectroscopy (FTIR) & LC-MS analysis. Methods: Classical raudra rasa (CRR), its ingredients, shadguna kajjali (SK); decoction of Piper betel Linn. (PBD); Amaranthus spinosus Linn. (ASD); Boerhaavia diffusa Linn. (BDD); Piper longum Linn. (PLD); cow urine (GM), & similarly modified raudra rasa (MRR), its ingredients, hiraka bhasma (HB); shadguna rasasindura (SHR); water-soluble extract of Piper betel Linn. (PBE); Amaranthus spinosus Linn. (ASE); Boerhaavia diffusa Linn. (BDE); cow urine ark (GA); Piper Longum Linn. (PLE) were subjected to FTIR and LC-MS analysis. Results: Among all 15 samples studied, maximum numbers of peaks (21) were seen in MRR indicating a greater number of functional groups. Further, in MRR, a maximum peak in the double bond region is suggestive of its higher stability compared to CRR. Both the compound is preliminarily a mixture of the number of functional groups like; fluoro, methyl, amino, hydroxy, nitro, methylamino, carbonyl, and iodo groups, having known anti-proliferative activities. By the FT-IR analysis, the biologically active compounds in aqueous and methanol extract of CRR & MRR were identified that have anti-cancerous compounds. In the present study, a total of 40 major compounds like alkaloids, amino acid, carboxylic acid, Flavonoids, Nucleoside, Nucleotide, phenylpropanoid, Sphingosine, stilbenoid, sugar, phosphate, terpenoids, vitamin from aqueous & methanol extract of CRR & MRR were identified by LC-MS. Conclusions: This research paper highlights the presence of different functional groups and bioactive compounds known to have anti-cancer activities. Thus, this review suggests future recommendations for the design and development of improved anticancer drugs with higher efficacy. © 2022 Walter de Gruyter GmbH, Berlin/Boston.
The Impact of Job Satisfaction on Teacher Mental Health: A Call to Action for Educational Policymakers
(Walter de Gruyter GmbH, 2024) Yogendra Kumar Singh; Dev Nath Singh Gautam
Job satisfaction significantly impacts teachers' overall well-being and mental health. Research reveals a strong connection between employment status and mental health, with teaching being a particularly stressful profession. The COVID-19 pandemic exacerbated these challenges, with the shift to online education and limited support causing heightened stress, anxiety, and depression. This study analyses scientific literature exploring the link between job satisfaction and mental health (depression, stress, and anxiety) in teachers. By examining relevant articles in major databases like Web of Science, PSYNDEX, PsycINFO, MEDLINE, EMBASE, and Google Scholar, the research identifies numerous sociodemographic and institutional factors contributing to teachers' mental health struggles, including workload, teaching experience, job satisfaction, gender, and the nature of online education. The findings highlight the urgent need for educational policymakers to develop policies prioritizing teacher well-being, especially during times of crisis. This involves addressing factors affecting job satisfaction and implementing strategies to promote mental health support for educators. © 2024 the author(s), published by De Gruyter.