Browsing by Author "Dinesh Kumar Chellappan"

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Advances in Lung Cancer Treatment Using Nanomedicines
(American Chemical Society, 2023) Akshansh Sharma; Devanshi Shambhwani; Sadanand Pandey; Jay Singh; Hauzel Lalhlenmawia; Murali Kumarasamy; Sachin Kumar Singh; Dinesh Kumar Chellappan; Gaurav Gupta; Parteek Prasher; Kamal Dua; Deepak Kumar
Carcinoma of the lungs is among the most menacing forms of malignancy and has a poor prognosis, with a low overall survival rate due to delayed detection and ineffectiveness of conventional therapy. Therefore, drug delivery strategies that may overcome undesired damage to healthy cells, boost therapeutic efficacy, and act as imaging tools are currently gaining much attention. Advances in material science have resulted in unique nanoscale-based theranostic agents, which provide renewed hope for patients suffering from lung cancer. Nanotechnology has vastly modified and upgraded the existing techniques, focusing primarily on increasing bioavailability and stability of anti-cancer drugs. Nanocarrier-based imaging systems as theranostic tools in the treatment of lung carcinoma have proven to possess considerable benefits, such as early detection and targeted therapeutic delivery for effectively treating lung cancer. (Figure presented) Several variants of nano-drug delivery agents have been successfully studied for therapeutic applications, such as liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, hydrogels, and micelles. In this Review, we present a comprehensive outline on the various types of overexpressed receptors in lung cancer, as well as the various targeting approaches of nanoparticles. © 2022 The Authors.
An overview of circular RNAs
(Springer New York LLC, 2018) Rajendra Awasthi; Anurag Kumar Singh; Gaurav Mishra; Anand Maurya; Dinesh Kumar Chellappan; Gaurav Gupta; Philip Michael Hansbro; Kamal Dua
Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5′–3′ polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker. CirRNAs can translate in vivo to link between their expression and disease. They are resistant to RNA exonuclease and can convert to the linear RNA by microRNA which can then act as competitor to endogenous RNA. This chapter summarizes the evolutionary conservation and expression of cirRNAs, their identification, highlighting various computational approaches on cirRNA, and translation with a focus on the breakthroughs and the challenges in this new field. © 2018, Springer Nature Singapore Pte Ltd.
Exploring nutritional supplement use for countering respiratory tract infections through an X (formerly Twitter)-based survey
(Elsevier B.V., 2025) Rajeev K. Singla; Himel Mondal; Shailja Singla; Ronita De; Sahar Behzad; Mihnea Alexandru Gǎman; Siva Sai Chandragiri; Merisa Ćenanović; Jayanta Kumar Patra; Jennifer R. Depew; Boyina Hemanth Kumar; Abdulkadir Yusif Maigoro; Soojin Lee; Omar Mohammad Atrooz; Gitishree Das; Fabien Schultz; Emad M. Abdallah; Hitesh Chopra; Jamil Ahmad; Rupesh Kumar Gautam; Sourav Sanchit Patnaik; Goh Bey Hing; Smith Borakaeyabe Babiaka; Sharad Vats; Michael P. Okoh; Atallah F. Ahmed; Ankit Kumar Dubey; Ronan Lordan; Parasuraman Aiya Subramani; Amit Kumar Singh; José M. Alvarez-Suarez; Dinesh Kumar Chellappan; Shravan Kumar Paswan; Prabhakar Semwal; Johra Khan; Sadeeq Muhammad Sheshe; Neeraj Kumar Sethiya; Tomasz M. Karpiński; Muhammad Ijaz Riaz; Zahra Emam-Diomeh; Girish Kumar Gupta; Reecha Madaan; Suresh Kumar; Neeraj Choudhary; Salvatore Parisi; Harald Willschke; Vasil Radoslavov Pirgozliev; Rehab A. Rayan; Valentin Ritschl; Shaikat Mondal; Gokhan Zengin; Pritt Verma; Bhupinder Kapoor; Monica Gulati; Gareeballah Osman Adam Balla; Dan Khoa Le; Valeria Pittalà; Amr El-Demerdash; Garba Mohammed Khalid; Jesus Simal-Gandara; Qushmua E. Alzahrani; G. L. RUSSO; Kiran R. Kharat; Anupam Bishayee; Dongdong Wang; I. E. Orhan; Hammad Ullah; Michael M. Heinrich; Bikash Baral; Nikolay T. Tzvetkov; Andy Wai Kan Yeung; João Dias-Ferreira; Scarlett Perez Olea; Yugal Kishore Mohanta; Azazahemad A. Kureshi; Claudiu T. Supuran; Neeraj Rani; Rohit Gundamaraju; Eoghan Joseph Mulholland; Sara Di Lonardo; Albena T. Dinkova-Kostova; Elena Ma González-Burgos; Lucian Hriţcu; Pravin Badhe; Abhilasha Singh; Fuad Al-Rimawi; Antoni Sureda Gomila; Rambod Abiri; Nady Braidy; Lorenz Kapral; A. N. Abdullahi; Christhian Delfino Villanueva Medina; Helen Sheridan; Massimo Lucarini; A. Durazzo; Francesca Giampieri; Davide Barreca; Witkowska Anna Maria; J. C. Andrade; Carmela Fimognari
Background: Respiratory tract infections are a common health issue, driving interest in preventive strategies like nutritional supplements, while evidence on their usage and effectiveness remains limited. In this context, social media platforms, particularly X (formerly Twitter), provide a unique opportunity to gather large-scale public health-related data. Objectives: In this study, we aimed to survey participants’ uses and opinions on nutritional supplements in prevention or treatment of respiratory tract infections, by using X. Methods: A survey was conducted between 1st and 15th December 2022. A single open-ended question “Which are the best dietary supplements to counteract respiratory infections?“ was asked. One week after the start of the survey, a poll was posted to get more relevant information and boost the survey's reach. Total endorsements were calculated for each tweet posted as the total sum of replies, retweets, and likes. Results: The open-ended question received a total of 118 retweets, 39 quotes, and 371 likes, while the poll received 56 retweets, 13 quotes, and 67 likes. A total of 495 replies, 2,251 retweets, 5,118 likes, and 148 quotes were received for the question and its related tweets. Vitamin D (1,607 endorsements), zinc (1,347 endorsements), vitamin C (803 endorsements), magnesium (694 endorsements), and honey (661 endorsements) were the nutritional supplements that received most endorsements. Conclusion: Various foods, drinks, and natural ingredients have been suggested as potentially helpful for counteracting respiratory infections. Approximately half of respondents indicated using such supplements for themselves. The result of this study supports the idea that the X platform can be used as an effective survey tool to study global health-related behaviours and trends. © 2025 The Authors
Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation
(Hindawi Limited, 2022) Md. Mominur Rahman; Md. Rezaul Islam; Sadia Afsana Mim; Nasrin Sultana; Dinesh Kumar Chellappan; Kamal Dua; Mohammad Amjad Kamal; Rohit Sharma; Talha Bin Emran
G protein-coupled receptors (GPCRs) are intricately involved in the conversion of extracellular feedback to intracellular responses. These specialized receptors possess a crucial role in neurological and psychiatric disorders. Most nonsensory GPCRs are active in almost 90% of complex brain functions. At the time of receptor phosphorylation, a GPCR pathway is essentially activated through a G protein signaling mechanism via a G protein-coupled receptor kinase (GRK). Dopamine, an important neurotransmitter, is primarily involved in the pathophysiology of several CNS disorders; for instance, bipolar disorder, schizophrenia, Parkinson's disease, and ADHD. Since dopamine, acetylcholine, and glutamate are potent neuropharmacological targets, dopamine itself has potential therapeutic effects in several CNS disorders. GPCRs essentially regulate brain functions by modulating downstream signaling pathways. GPR6, GPR52, and GPR8 are termed orphan GPCRs because they colocalize with dopamine D1 and D2 receptors in neurons of the basal ganglia, either alone or with both receptors. Among the orphan GPCRs, the GPR52 is recognized for being an effective psychiatric receptor. Various antipsychotics like aripiprazole and quetiapine mainly target GPCRs to exert their actions. One of the most important parts of signal transduction is the regulation of G protein signaling (RGS). These substances inhibit the activation of the G protein that initiates GPCR signaling. Developing a combination of RGS inhibitors with GPCR agonists may prove to have promising therapeutic potential. Indeed, several recent studies have suggested that GPCRs represent potentially valuable therapeutic targets for various psychiatric disorders. Molecular biology and genetically modified animal model studies recommend that these enriched GPCRs may also act as potential therapeutic psychoreceptors. Neurotransmitter and neuropeptide GPCR malfunction in the frontal cortex and limbic-related regions, including the hippocampus, hypothalamus, and brainstem, is likely responsible for the complex clinical picture that includes cognitive, perceptual, emotional, and motor symptoms. G protein and GPCR-mediated signaling play a critical role in developing new treatment options for mental health issues, and this study is aimed at offering a thorough picture of that involvement. For patients who are resistant to current therapies, the development of new drugs that target GPCR signaling cascades remains an interesting possibility. These discoveries might serve as a fresh foundation for the creation of creative methods for pharmacologically useful modulation of GPCR function. © 2022 Md. Mominur Rahman et al.
Therapeutic Potential of Phytoconstituents in Management of Alzheimer's Disease
(Hindawi Limited, 2021) Anurag Kumar Singh; Sachchida Nand Rai; Anand Maurya; Gaurav Mishra; Rajendra Awasthi; Anshul Shakya; Dinesh Kumar Chellappan; Kamal Dua; Emanuel Vamanu; Sushil Kumar Chaudhary; M.P. Singh
Since primitive times, herbs have been extensively used in conventional remedies for boosting cognitive impairment and age-associated memory loss. It is mentioned that medicinal plants have a variety of dynamic components, and they have become a prominent choice for synthetic medications for the care of cognitive and associated disorders. Herbal remedies have played a major role in the progression of medicine, and many advanced drugs have already been developed. Many studies have endorsed practicing herbal remedies with phytoconstituents, for healing Alzheimer's disease (AD). All the information in this article was collated from selected research papers from online scientific databases, such as PubMed, Web of Science, and Scopus. The aim of this article is to convey the potential of herbal remedies for the prospect management of Alzheimer's and related diseases. Herbal remedies may be useful in the discovery and advancement of drugs, thus extending new leads for neurodegenerative diseases such as AD. Nanocarriers play a significant role in delivering herbal medicaments to a specific target. Therefore, many drugs have been described for the management of age-linked complaints such as dementia, AD, and the like. Several phytochemicals are capable of managing AD, but their therapeutic claims are restricted due to their lower solubility and metabolism. These limitations of natural therapeutics can be overcome by using a targeted nanocarrier system. This article will provide the primitive remedies as well as the development of herbal remedies for AD management. © 2021 Anurag Kumar Singh et al.