Browsing by Author "Divya Atri"

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Cerebrospinal fluid zinc, magnesium, copper and gamma-aminobutyric acid levels in febrile seizures
(IOS Press, 2007) Om Prakash Mishra; Deepak Singhal; Ram Sanmukh Upadhyay; Rajniti Prasad; Divya Atri
The exact etiopathogenesis of febrile seizures (FS) is unknown. The present study was conducted to evaluate the cerebrospinal fluid (CSF) zinc (Zn), magnesium (Mg), copper (Cu) and gamma-aminobutyric acid (GABA) levels in children with FS. The study subjects included 20 cases of FS, 26 patients of encephalitis and 22 children of fever with meningismus. The Zn, Mg and Cu levels in CSF and serum were analyzed by atomic absorption spectrophotometry and GABA was estimated by paper chromatography method. The mean CSF Zn, Mg and Cu values were significantly decreased in FS in comparison to encephalitis and fever with meningismus cases (P<0.05). The mean serum Zn and Mg levels were also decreased in FS patients when compared with other two groups (P<0.05). No significant changes were observed in serum Cu levels among the three groups. There was no significant difference in the mean levels of CSF and serum GABA between FS and encephalitis, but the values were found to be significantly decreased when compared with fever with meningismus (P<0.05). Patients of FS having higher body temperature (>37.9°C) had significantly decreased levels of CSF (P<0.05) and serum GABA (P<0.01) in comparison to those having temperature of 37.2-37.8°C. Significant positive correlations were found between CSF and serum Zn, Mg and GABA values. The CSF Zn also had significant positive correlations with CSF Mg and GABA levels. These findings suggest a relationship between low levels of Zn, Mg and GABA and predisposition to FS in children. © 2007 IOS Press. All rights reserved.
Serum lipids and lipoprotein(a) levels in children with idiopathic nephrotic syndrome
(2012) Om P. Mishra; Rajniti Prasad; Divya Atri; Surya K. Singh; Ziledar Ali
The present study was carried out prospectively to evaluate serum lipids and lipoprotein(a) levels in children with nephrotic syndrome during the active phase of disease and during a remission. Serum lipids and lipoprotein(a) levels were measured in 40 children, aged 2-10 years, during the active phase of nephrotic syndrome; 25 with a first attack, 9 infrequent relapsers and 6 frequent relapsers, and during remission and in 20 healthy age-matched controls. The mean serum lipids and lipoprotein(a) levels were significantly raised during the active phase of nephrotic syndrome (p< 0.001). The values were relatively higher in relapsers. The lipids and lipoprotein(a) levels decreased during a remission but were significantly higher (p< 0.05) than controls. Serum lipids had a negative correlation with serum albumin and lipoprotein(a) had a positive correlation with proteinuria (r=0.5246, p< 0.01) but no correlation with serum albumin. The elevated lipids and lipoprotein(a) in both the active phase of nephrotic syndrome and during remission suggest a possible predisposition to atherosclerosis in future. © 2012 - IOS Press and the authors.
Serum lipids and lipoprotein(a) levels in children with idiopathic nephrotic syndrome
(Georg Thieme Verlag, 2012) Om P. Mishra; Rajniti Prasad; Divya Atri; Surya K. Singh; Ziledar Ali
The present study was carried out prospectively to evaluate serum lipids and lipoprotein(a) levels in children with nephrotic syndrome during the active phase of disease and during a remission. Serum lipids and lipoprotein(a) levels were measured in 40 children, aged 2-10 years, during the active phase of nephrotic syndrome; 25 with a first attack, 9 infrequent relapsers and 6 frequent relapsers, and during remission and in 20 healthy age-matched controls. The mean serum lipids and lipoprotein(a) levels were significantly raised during the active phase of nephrotic syndrome (p < 0.001). The values were relatively higher in relapsers. The lipids and lipoprotein(a) levels decreased during a remission but were significantly higher (p < 0.05) than controls. Serum lipids had a negative correlation with serum albumin and lipoprotein(a) had a positive correlation with proteinuria (r = 0.5246, p < 0.01) but no correlation with serum albumin. The elevated lipids and lipoprotein(a) in both the active phase of nephrotic syndrome and during remission suggest a possible predisposition to atherosclerosis in future. © 2012 - IOS Press and the authors. All rights reserved.