Browsing by Author "Gajendra SINGH"

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Congenital Amputation of All the Limbs Related with Amniotic Rupture
(1990) Jay Datta SINGH; Gajendra SINGH
A female infant born with all the four limbs amputated close to the proximal ends is reported. The parents both Indians, having six normal children with poor socio‐economic background denied family history of any congenital anomalies. The mother neither suffered any illness nor had exposure to any known teratogen to the best of their knowledge during this pregnancy. However the mother had attempted to abort this baby in the week 7 of gestation with help of an indigenous mechanical device, a herbal stick, per vaginam which resulted in gushing out of some fluid (amniotic fluid) only. This unsuccessfully attempted abortion neither affected the mother nor the pregnancy apparently and on full term this baby was born. When examined on postnatal day 33, the baby looked very healthy, alert and responsive weighing 3500 g, with CR length 38 cm and occipito‐frontal circumference 35 cm. No abnormalities were observed except that all the limbs were amputated just distal to their proximal end. The baby could move all the stumps of the amputated limbs actively. This case seems to be first of its kind being reported from India. The etio‐pathogenesis of amputation of limbs was reviewed and evaluated in the light of the available literature. Of the possible etiological factors suggested in the literature the most convincing mode of amputation of all the limbs simultaneously in the present case seems to be the multiple amniotic band formation. Copyright © 1990, Wiley Blackwell. All rights reserved
Spontaneous Intrauterine Repairment of Cleft Palate Induced by Amniocentesis in Rats
(1991) Chhandamayee MOHANTY; Gajendra SINGH; Braja Kishore DAS
On day 15 of gestation, 180 fetal sacs in 43 pregnant Charles Foster rats were subjected to amniocentesis producing a series of total or partial clefts in the hard and soft palate regions. Fetuses recovered on days 19, 20 or 21 showed a gradual decline in the incidence of total clefts with increasing gestational age, i.e. 34% on day 19, 29% on day 20 and 13% on day 21, suggesting spontaneous ‘repairment’ of the clefts induced by amniotic sac puncture. Prenatal ‘repairment’ at times leaving residual partial clefts in the hard palate, suggested delayed rotation of the palatine shelves following reaccumulation of lost quantity of amniotic fluid and withdrawal of tongue obstruction. The experiment suggested that the palatine shelves retain intrinsic ‘shelf force’ for a much longer period than thought earlier. However, a gradual increase in the incidence of residual partial cleft with increasing gestational age, i.e. 45% on day 19; 50% on day 20 and 67% on day 21, respectively, suggests only incomplete (partial) repair in most of the cases probably due to paucity of time. Copyright © 1991, Wiley Blackwell. All rights reserved