Browsing by Author "H. Sharma"

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A prospective study comparing conservative with operative treatment in patients with a 'floating shoulder' including assessment of the prognostic value of the glenopolar angle
(British Editorial Society of Bone and Joint Surgery, 2013) V. Yadav; G.N. Khare; S. Singh; V. Kumaraswamy; N. Sharma; A.K. Rai; A.G. Ramaswamy; H. Sharma
Both conservative and operative forms of treatment have been recommended for patients with a 'floating shoulder'. We compared the results of conservative and operative treatment in 25 patients with this injury and investigated the use of the glenopolar angle (GPA) as an indicator of the functional outcome. A total of 13 patients (ten male and three female; mean age 32.5 years (24.7 to 40.4)) were treated conservatively and 12 patients (ten male and two female; mean age 33.67 years (24.6 to 42.7)) were treated operatively by fixation of the clavicular fracture alone. Outcome was assessed using the Herscovici score, which was also related to changes in the GPA at one year post-operatively. The mean Herscovici score was significantly better three months and two years after the injury in the operative group (p < 0.001 and p = 0.003, respectively). There was a negative correlation between the change in GPA and the Herscovici score at two years follow-up in both the conservative and operative groups, but neither were statistically significant (r = -0.295 and r = -0.19, respectively). There was a significant difference between the pre- and post-operative GPA in the operative group (p = 0.017). When compared with conservative treatment, fixation of the clavicle alone gives better results in the treatment of patients with a floating shoulder. The GPA changes significantly with fixation of clavicle alone but there is no significant correlation between the pre-injury GPA and the final clinical outcome in these patients. ©2013 The British Editorial Society of Bone & Joint Surgery.
Evaluation of in vivo wound healing activity of Bacopa monniera on different wound model in rats
(2013) S. Murthy; M.K. Gautam; Shalini Goel; V. Purohit; H. Sharma; R.K. Goel
Wound healing effects of 50% ethanol extract of dried whole plant of Bacopa monniera (BME) was studied on wound models in rats. BME (25 mg/kg) was administered orally, once daily for 10 days (incision and dead space wound models) or for 21 days or more (excision wound model) in rats. BME was studied for its in vitro antimicrobial and in vivo wound breaking strength, WBS (incision model), rate of contraction, period of epithelization, histology of skin (excision model), granulation tissue free radicals (nitric oxide and lipid peroxidation), antioxidants (catalase, superoxide dismutase, and reduced glutathione), acute inflammatory marker (myeloperoxidase), connective tissue markers (hydroxyproline, hexosamine, and hexuronic acid), and deep connective tissue histology (dead space wound). BME showed antimicrobial activity against skin pathogens, enhanced WBS, rate of contraction, skin collagen tissue formation, and early epithelization period with low scar area indicating enhanced healing. Healing effect was further substantiated by decreased free radicals and myeloperoxidase and enhanced antioxidants and connective tissue markers with histological evidence of more collagen formation in skin and deeper connective tissues. BME decreased myeloperoxidase and free radical generated tissue damage, promoting antioxidant status, faster collagen deposition, other connective tissue constituent formation, and antibacterial activity. © 2013 S. Murthy et al.
Mass measurements of proton-rich nuclides in the vicinity of 92Ru and 93Rh for νp-process models
(2008) J. Fallis; J.A. Clark; K.S. Sharma; G. Savard; F. Buchinger; S. Caldwell; J.E. Crawford; C.M. Deibel; J.L. Fisker; S. Gulick; A.A. Hecht; D. Lascar; J.K.P. Lee; A.F. Levand; G. Li; A. Parikh; N.D. Scielzo; R. Segel; H. Sharma; M. Sternberg; T. Sun; J. Van Schelt; C. Wrede
One of the long-standing questions in our understanding of the origin of the elements is the significant underproduction of light-p nuclei such as 92Mo and 94Mo by models of nucleosynthesis in various astrophysical scenarios. The recently proposed νp-process [1], which occurs due to the interaction of the neutrino wind with the proton-rich ejecta of core collapse supernova explosions, is a process which could resolve the underproduction of 92Mo and 94Mo. The final abundances of these two isotopes as well as any others synthesized by the νp-process depend directly on the values of the proton separation energies, Sp, along the νp-process reaction path; the Sp value of 93Rh is thought to be especially critical to the relative production of 92Mo and 94Mo [2]. Due to the absence of mass measurements in this region Sp(93Rh) and many of the other required Sp values were not well known. Recent mass measurements performed with the Canadian Penning Trap mass spectrometer have reduced uncertainties in the Sp values of many of the proton-rich nuclei between Mo and Pd including S p(93Rh) by factors of as much as 60. These measurements and the resulting implications for both the ∪-process path and the 92Mo/94Mo abundance ratio will be discussed. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlikeLicence.