Browsing by Author "I.S. Gambhir"

Now showing 1 - 20 of 34

A case of post bee sting encephalitis
(2006) Suresh Venkata Satya Attili; I.S. Gambhir; P. Suba Rao; Mukesh Kumar; Himanshu Mehata; Ajay Gogia; S.H.K. Raju
Bee Sting in most of the situations is potentially serious. The spectrum of bee sting disease ranges from mild local reaction to death. The literature regarding the bee sting disease from India is sparse. The rare manifestations of the disease include encephalitis, polyneuritis, myocardial infarction, pulmonary edema, bleeding manifestations and renal failure. Here we are reporting a rare case of encephalitis developing 3 days following the bee sting.
A case of Pseudohypoparathyroidism 1a (PHP 1a)
(2003) I.S. Gambhir; Alok Kumar Singh
[No abstract available]
A young female with left sided focal seizure
(2010) D. Kishore; V. Khurana; I.S. Gambhir
[No abstract available]
Acute diarrhoea in elderly
(1999) I.S. Gambhir; J.P. Jaiswal; A.K. Singh; D.S. Singh
[No abstract available]
Acute non-calculus cholecystitis in virus B hepatitis.
(1996) D.S. Singh; S.R. Saxena; A.K. Singh; I.S. Gambhir
[No abstract available]
Acute rheumatic fever.
(2002) I.S. Gambhir; A. Srivastava; P. Sadana
[No abstract available]
Angiotensin-converting enzyme gene I/D polymorphism increases the susceptibility to hypertension and additive diseases: A study on North Indian patients
(Taylor and Francis Ltd, 2016) M. Singh; A.K. Singh; S. Singh; P. Pandey; S. Chandra; I.S. Gambhir
Angiotensin-converting enzyme (ACE) is the key enzyme of the renin angiotensin system (RAS) which maintains the blood pressure homeostasis in our body. The association of the ACE insertion/deletion (I/D) polymorphism with essential hypertension has been demonstrated by many studies. The purpose of the present study is to investigate the association of the insertion/deletion polymorphism of the ACE gene with hypertension and additive diseases in North Indian population. In total, 222 hypertensive and 218 normotensive adults participated in this hospital-based study. Anthropometric measures, lipids profiles, blood glucose, and blood pressure (BP) measures were collected from participants. ACE I/D polymorphism was determined by using insertion-specific amplification. Themean ages of study groups were 50.35 ± 12.40 and 47.32 ± 11.94 for cases and controls, respectively. Significant differences were observed in the frequencies of DD, ID, and II genotypes among the hypertensive and normotensive groups which were found to be 29.7%, 38.7%, and 31.5% vs. 53.7%, 23.4%, and 22.9%, respectively. It has been observed that the ACE ID genotype was significantly (p < 0.05) higher in hypertensive subjects, whereas, the DD genotype was significantly (p < 0.05) higher in control subjects. A strong association was found between cardiovascular diseases (CVDs) and ID genotype [p = 0.017, odds ratio (OR) = 3.091, 95%confidence interval (CI) = 1.224-7.807]. ID [p = 0.002, OR = 2.020, 95% CI = 1.281-3.185] and II [p = 0.032, OR = 1.677, 95%CI = 1.044-2.694] genotypes aremore prone to diabetes with hypertension. This finding suggests that ACE insertion/deletion polymorphismis associated with hypertension and additive diseases in North Indians. © 2016 Taylor & Francis.
Cardiac changes in acute viral hepatitis in Varanasi (India): Case reports
(1989) D.S. Singh; P.R. Gupta; S.S. Gupta; P.K. Bhatia; P.N. Somani; I.S. Gambhir; A.K. Khare
Three cases of acute viral hepatitis are reported with various cardiac changes such as transient left ventricular hypertrophy, myocarditis and progressive cardiomegaly (cardiomyopathy). Extra-hepatic manifestations of acute viral hepatitis are rare but have been well documented. The aims of the present study are to highlight the cardiac involvement in acute viral hepatitis and to report the clinical implications of cardiac changes in acute viral hepatitis.
Cerebral Malaria in Eastern U.P. (India) - A study under clinical practice conditions
(2005) A.K. Singh; A. Srivastava; I.S. Gambhir
Cerebral malaria caused by P. falciparum is a common condition. Clinical profile differs in different parts of world and during epidemics. The objective of study was to document clinical profile of Cerebral Malaria in Eastern UP (North India) which is an endemic area and use of paracheck (Hrp2) as a criteria for diagnosis. Patients with fever, unconsciousness and Hrp2 positivity with exclusion of other causes were diagnosed and treated as cerebral malaria. 40 such patients with mean age 31.5 ± 15.04 years and M:F ratio 3:1 were seen in year 2001-02 with high incidence in rainy season. There was greater incidence of meningeal signs, hepatic and renal involvement but lesser convulsions. Neurological sequelae were common with post malarial psychosis being the commonest. Leucocytosis was commoner than leucopenia. Blood film microscopy was less sensitive than Hrp2 based paracheck test in diagnosis of cerebral malaria. The latter may be used in clinical practice conditions with some reservations.
Clinical presentation in elderly: An overview
(1999) I.S. Gambhir
[No abstract available]
Clinico radiological evaluation of non-obstructive renal tuberculosis
(1989) R.G. Singhi; I.S. Gambhir; J. Mathur; Usha; K.V. Johny
Twenty cases of A.F.B. culture positive renal tuberculosis without any obstructive feature as demonstrated by I.V.P. were studied. Gross hematuria, dysuria were common presenting symptoms. Proteinuria was present in 14 cases and in 7 cases it was in the nephrotic range. Urine culture was sterile for secondary micro-organism in 6 cases. Hypertension was a presenting feature in 3 cases. Chronic renal failure and acute renal failure were only observed in one case. Pyelographic findings suggestive of renal tuberculosis were present in half of the cases. Associated extragenital tuberculosis was seen in one fourth of cases.
CNS toxoplasmosis with HIV infection: A case report
(2002) I.S. Gambhir; Abhishek
[No abstract available]
Comparative clinical evaluation of an ayurvedic regimen in the management of senile dementia
(International Journal of Research in Ayurveda and Pharmacy, 2013) Ansari Obed Ahmed; J.S. Tripathi; I.S. Gambhir
An enhanced life expectancy in developed countries has been accompanied by an increased number of people suffering from age-associated dementia. Senile dementia is a syndrome due to disease of the brain, usually of a chronic or progressive nature, in which there is disturbance of multiple higher cortical functions, without any impairment in consciousness. Prevalence rates for senile dementia increase essentially with advancing age. The prevalence rate rises to 54.8% in individuals above 95 years of age. So far, efforts to find a cure for Alzheimer Disease (AD) have been disappointing, and the drugs currently available to treat the disease address only its symptoms and with limited effectiveness. Present study was design to see the efficacy of Saraswata ghrita along with Shirobasti on Senile dementia. A total number of 34 patient of Senile dementia were recruited by using ICD- 10 criteria of Dementia and MMSE scores and randomly divided in to two groups. Alzheimer's disease assessment scale (cognitive subscale) has been used to evaluate the clinical condition of the patients of Senile dementia. After completion of treatment Saraswata ghrita along with Shirobasti shows statistically significant results on clinical and neuro-cognitive parameters.
Constipation: A common gut dysmotility problem in the elderly
(1999) D.S. Singh; A.K. Singh; A. Mehrotra; I.S. Gambhir
[No abstract available]
Cryptococcal meningitis with an antecedent cutaneous Cryptococcal lesion
(Dermatology Online Journal, 2009) Ragini Tilak; Pradyot Prakash; Chaitanya Nigam; Vijai Tilak; I.S. Gambhir; A.K. Gulati
Cutaneous cryptococcosis, caused by an encapsulated yeast, Cryptococcus neoformans, is generally associated with concomitant systemic infection. Here we report a case of primary cutaneous cryptococcosis with spread to central nervous system in an HIV seronegative young boy. In the present case, a 17-year-old boy who was suffering from a non-healing ulcer on his right great toe for 5 months, presented with the signs and symptoms of meningitis. Cryptococcus neoformans var. gattii was isolated from the CSF of the patient. Amphotericin B administration produced recovery from the meningitis as well as from the ulcer. This case study suggests that primary cutaneous cryptococcosis can be diagnosed provisionally by a simple Gram stained smear and India ink examination in order to avoid occurrence of disseminated cryptococcosis, including meningial involvement, which may have a fatal outcome. © 2009 Dermatology Online Journal.
Electrocardiographic changes in relation with CT scan parameters in spontaneous intracerebral haemorrhage
(1997) I.S. Gambhir; S.S. Gupta; D.S. Singh; A. Srivastva
Sixty-three patients of spontaneous intracerebral hemorrhage proved by computerised axial tomography (CT) scan were studied for electrocardiographic (ECG) changes and their correlation with CT scan parameters. ECG changes were observed in 81% (51 patients) with 28% mortality as compared to 9% mortality in patients without ECG changes. In 87% of survivors ECG changes regressed in 1st week of hospitalisation. ECG changes in all three parameters i.e. automaticity, conduction and repolarisation correlated well with mortality (60%), ventricular communication (VC), mass effect (ME) and volume of hematoma.
Evaluation of CSF-Adenosine Deaminase Activity in Tubercular Meningitis
(1999) I.S. Gambhir; M. Mehta; D.S. Singh; H.D. Khanna
Sixty patients of inflammatory brain disease were diagnosed and classified according to clinico-investigational criteria by Ahuja et al into tuberculous meningitis group (36 patients) and non-tuberculous meningitis group (24 patients). Tuberculous meningitis (TBM) patients were classified as probable (9 patients) and possible (27 patients) TBM. Non-TBM group comprised of pyogenic meningitis (8.3%), viral encephalitis (23.3%), cerebral malaria (5%) and enteric encephalopathy (3.3%). Cerebrospinal fluid-adenosine deaminase (CSF-ADA) activities were measured in both TBM and non-TBM groups. Mean CSF-ADA levels in TBM patients was 9.61 ± 4.10 IU/L and was significantly elevated as compared to viral encephalitis and enteric encephalopathy cases; but difference was insignificant in comparison to pyogenic meningitis (7.92 ± 0.95 IU/L) and cerebral malaria. Using 8 IU/L as cut off value for diagnosis of TBM a sensitivity of 44% and specificity of 75% was observed.
Free radicals hasten head and neck cancer risk: A study of total oxidant, total antioxidant, DNA damage, and histological grade
(Medknow Publications, 2016) A.K. Singh; P. Pandey; M. Tewari; H.P. Pandey; I.S. Gambhir; H.S. Shukla
Background: Free radicals such as reactive oxygen species (ROS), which induce oxidative stress, are the main contributors to head and neck carcinogenesis (HNC). The present study was conducted with the aim to assess the oxidant/antioxidant status and DNA damage analysis in head and neck cancer/control patients. Materials and Methods: This prospective study was conducted on 60 patients with biopsy-proven HNC and 17 patients of head and neck disease (HND). The total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined by novel automatic colorimetric methods from tissue homogenate. DNA damage analysis was determined by single cell gel electrophoresis (SCGE). Results: The mean age of the study cohort was 46.65 ± 14.84 years for HNC patients, while it was 49.41 ± 13.00 years for HND patients. There were no significant differences found between the two groups with respect to demographic presentation except tobacco addiction. The association between oxidative stress parameters and DNA damage analysis with study group revealed the following. (A) DNA damage - tissue homogenate TOS and OSI were significantly higher in HNC subjects than in HND (16.06 ± 1.78 AU vs 7.86 ± 5.97 AU, P < 0.001; 53.00 ± 40.61 vs 19.67 ± 21.90, P < 0.01; 7.221 ± 5.80 vs 2.40 ± 2.54, P < 0.01, respectively), while TAS was significantly decreased. (B) Aggressive histological features were identified, more commonly with higher TOS and lower TAS [probability (P) = 0.002, relative risk (RR) = 11.838, 95% confidence interval CI = 2.514-55.730 and P = 0.043, RR = 0.271, 95% CI = 0.077-0.960, respectively]. Conclusion: The increase in free radicals may be the event that led to the reduction of antioxidant status in HNC, thus explaining the oxidative damage of DNA and the severity of disease. Increased OSI represents a general mechanism in its pathogenesis. © 2016 Journal of Postgraduate Medicine Published by Wolters Kluwer - Medknow.
Heliotrope rash and 'V' sign in dermatomyositis
(2003) P. Neehar; B. Benjamin; A. Sahu; A.K. Singh; I.S. Gambhir
[No abstract available]
Hepatic encephalopathy
(1998) I.S. Gambhir; D.S. Singh; A. Mehrotra
[No abstract available]