Browsing by Author "J.K. Agrawal"

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A study of risk factors in nonembolic cerebrovascular disease
(1976) J.K. Agrawal; P.N. Somani; B.C. Katiyar
A prospective hospital based study of the risk factors in 122 NECVD patients was undertaken. In this study, the peak and the mean ages were a decade lower than that of the West. Amongst the various risk factors, a positive family history, transient ischaemic attacks, hypertension, diabetes mellitus, and raised levels of serum phospholipids, free fatty acid and uric acid were found to be of statistical significance. Hypertension was more common in patients with cerebral haemorrhage. Diabetes mellitus was equally prevalent in patients having thrombosis or haemorrhage. Other factors like a positive family history, raised serum phospholipids and uric acid levels were associated with cerebral thrombosis only. Excessive smoking, physical inactivity, obesity, arcus senilis, serum total lipids, cholesterol and triglycerides were found to be of no significance. Carotid bruit was not heard in any of the patients.
Acrocephalosyndactyly - Type I (Apert's Syndrome)
(1999) S.K. Singh; Richa Chaturvedi; S.K. Pal; K.K. Singh; S.K. Sinha; J.K. Agrawal
[No abstract available]
Adrenal function in patients with active pulmonary tuberculosis
(1998) S.K. Singh; J.K. Samaria; J.K. Agrawal
Thirty-three patients with active pulmonary tuberculosis of duration less than three years were evaluated for adrenal function by standard synacthen test. A comparison was made between patient group and control group. The basal plasma cortisol value was significantly higher in patient group than control group. All patients had normal post synacthen cortisol value indicating intact adrenal function. However, the functional reserve of adrenal gland assessed by the urea under the response curve showed lower functional reserve in the patient group in comparison with control group. Adrenal function was normal in patients with tuberculosis but hyponatermia was present in 24.24% of cases. This reflects that serum sodium is a poor marker and predictor of adrenal function in tuberculosis patients. In conclusion adrenal function is intact in patients with active pulmonary tuberculosis of duration less than 3 years inspite of high prevalence of hyponatremia and low functional reserve of adrenal gland.
Adrenocortical insufficiency in smear positive pulmonary tuberculosis.
(1992) S.C. Matah; G.L. Kesharwani; G.N. Srivastava; S.K. Singh; J.K. Agrawal
We studied 40 patients with pulmonary tuberculosis. All were positive for acid-fast bacilli (AFB) in the sputum. Their mean age was 30 yrs (range 10-50 yrs) and the duration of illness was 26.3 +/- 2.3 months. Radiologically minimal, moderately advanced and far advanced lesions were present in 7 (17.5%), 9 (22.5%) and 23 (57.5%) patients respectively. One patient with endobronchial lesion had no radiological evidence of pulmonary tuberculosis. Clinically, 14 patients (35%) had one or the other features of adrenocortical insufficiency. Postural hypotension was the commonest feature and was present in 11 patients (27.5%), followed by nausea and vomiting (20%), loss of axillary hair and libido (10%), skin and mucosal pigmentation in 7.5% of the cases. ACTH stimulation revealed incomplete adrenocortical insufficiency (partially responsive adrenal) in 5 patients (12.5%) and complete adrenocortical insufficiency (non-responsive adrenal) in 2 patients (5%). Patients with features of adrenal insufficiency had significantly longer duration of illness (p < 0.001) but there was no correlation with extent or type of lesion.
Adrenoleukodystrophy Presenting as Addison's Disease in Childhood
(2000) S.K. Singh; Richa Chaturvedi; J.K. Agrawal
[No abstract available]
Association of hypomagnesemia with diabetic retinopathy
(1989) A. Hatwal; A.S. Gujral; R.P.S. Bhatia; J.K. Agrawal; H.S. Bajpai
Abstract Serum magnesium was measured in 100 patients of type II diabetes mellitus (40 without retinopathy, 40 with non‐proliferative and 20 with proliferative retinopathy) without malnutrition, hepatic or renal disease or albuminuria and in 100 age and sex matched controls. The serum magnesium levels were lower in diabetics than in controls (P< 0.001), and the levels in diabetics with non‐proliferative and proliferative retinopathy were significantly lower than in those without retinopathy (P< 0.001). These data seem to point towards an association between hypomagnesemia and diabetic retinopathy. 1989 Institution Acta Ophthalmologica Scandinavica
Bilateral Congenital Anorchia in Three Siblings
(1994) Madhukar Rai; J.K. Agrawal; V. Sasikumar; S.K. Singh
[No abstract available]
Biogenic amines and thyrotoxicosis
(1992) L. Upadhyaya; J.K. Agrawal; G.B. Dubey; K.N. Udupa
Circulating levels of T3, T4, γ-amino-butyric acid, glutamate, 5-hydroxytryptamine, histamine, monoamine oxidase and histaminase were studied in 45 (25M, 20F) hyperthyroid patients and 46 (25M, 21F) normal healthy volunteers. Increased levels of blood 5-hydroxytryptamine, histamine and glutamic acid were observed along with elevated T3 and T4, whereas plasma γ-aminobutyric acid, monoamine oxidase and histaminase activities were found to be low in both male and female patients. After three months of treatment, circulating levels of 5-hydroxytryptamine, histamine and glutamic acid decreased significantly along with normalization of thyroid hormones and with an increase in the concentrations of γ-aminobutyric acid, monoamine oxidase and histaminase. There was a positive correlation between these amines and thyroid hormone levels. The findings thus suggest that alterations in the metabolism of biogenic amines may be related to an altered metabolism in thyrotoxicosis, and these parameters may prove to be useful markers for diagnosis and follow-up of these patients.
Cerebral salt wasting syndrome in a patient with a pituitary adenoma
(2003) S.K. Singh; A.G. Unnikrishnan; V.S. Reddy; R.K. Sahay; S.K. Bhadada; J.K. Agrawal
Cerebral salt wasting syndrome (CSWS) is often an unrecognized cause of hyponatremia that occurs in the setting of intracranial lesions. It is important to differentiate CSWS from the syndrome of inappropriate ADH secretion, as this would alter the management of hyponatremia. We describe a case of CSWS that occurred in association with a non-functioning pituitary adenoma.
Clinical and biochemical profiles of young diabetics in North-Eastern India
(2002) V.P. Jyotsna; S.K. Singh; D. Gopal; A.G. Unnikrishnan; N.K. Agrawal; V.K. Dixit; A.K. Agrawal; J.K. Agrawal
Objective : We compared the clinical and biochemical profiles of young diabetics in North Eastern India. Methods : Seventy diabetics who were detected at less than 30 years of age were studied. Patients with ketoacidosis or ketonuria on insulin withdrawal were grouped as insulin dependent diabetes mellitus (IDDM), patients with history of chronic abdominal pain with or without exocrine pancreatic dysfunction who either on ultrasonography (USG) or endoscopic retrograde cholangiopancreaticoduodenography (ERCP) revealed pancreatic calcification and/or ductal dilatation were grouped as fibrocalculous pancreactic diabetes (FCPD), those having BMI < 19 kg/m2 with history or stigmata of childhood malnutrition and who were ketosis resistant were taken to be protein deficient diabetes mellitus (PDDM)/malnutrition modulated diabetes mellitus (MMDM) and those who neither had ketonuria nor history of chronic abdominal pain, malabsorption or stigmata of malnutrition were grouped as NIDDM of young (NIDDY). Results : Amongst the young diabetics studied FCPD constituted 32.9%, IDDM 28.6%, MMDM 21.4% and NIDDY 17.11%. USG abnormalities were observed in 21 of the 23 patients of FCPD. Seven out of these showed pancreatic head calcification on X-ray while 14 showed pancreatic duct dilatation and calcification or calculi on USG. In the two remaining patients, ERCP revealed tortuousity of main pancreatic duct and calcification which were not detected on USG. Majority of FCPD and MMDM patients revealed insulin resistance on insulin tolerance test (ITT). HDL was significantly lower in NIDDY, while VLDL and triglycerides were significantly higher in FCPD and MMDM as compared to controls. Microvascular complications of diabetes were seen in all these groups, with peripheral neuropathy being more common in FCPD (43.5%) and background diabetic retinopathy in NIDDY (41%). Conclusions : We conclude that FCPD and MMDM together form majority (54.29%) of young diabetics at our center and a sizeable proportion of them may have microvascular complications, even at the time of diagnosis.
Combination therapy in management of NIDDM
(Association of Physicians of India, 1998) S.K. Singh; V.K. Shukla; D. Sarkar; J.K. Agrawal
[No abstract available]
Congestive heart failure and septic abortion
(BMJ Publishing Group, 1999) S.K. Singh; Pawan Arora; Shailendra Kumar Singh; Salil Pal; K.K. Singh; J.K. Agrawal
[No abstract available]
Cranial Irradiation - An Unusual Cause for Diabetes Insipidus
(2000) V.P. Jyotsna; S.K. Singh; Richa Chaturvedi; B. Neogi; S.K. Bhadada; R.K. Sahay; J.K. Agrawal
Central diabetes insipidus frequently occurs due to tumours in the region of pituitary or hypothalamus or following surgical trauma to these regions. Rarely it has been reported following cranial irradiation. We report the case of a middle aged woman who underwent surgical removal of a frontal capillary hemangioblastoma and received cranial irradiation. She presented ten months later with features of diabetes insipidus which was confirmed to be of central origin. She responded well to desmopressin nasal spray. Radiation induced damage to the hypothalmo-pituitary axis presents usually with anterior pituitary hormone deficiences, most commonly that of growth hormone. Presentation as central diabetes insipidus is very uncommon.
Effect of fenfluramine on serum T3, T4 and TSH levels in obesity
(1992) S.S. Gupta; J.K. Agrawal; H.S. Bajpai; R.P. Bhatt; S.K. Singh
[No abstract available]
Effect of l-thyroxine and carbimazole on brain biogenic amines and amino acids in rats
(Informa Healthcare, 1993) L. Upadhyaya; J.K. Agrawal
Effect of L-thyroxine and carbimazole on brain biogenic amines and amino acids content and circulating levels of thyroid hormones has been investigated in rats. L-thyroxine treatment caused marked elevation of 5-HT, histamine and glutamate along with the decline in the level of GABA whereas administration of carbimazole had a contrary effect on rat hypothalamus. Further, L-thyroxine administration also raised histamine as well as glutamate content and decreased GABA level in thalamic region of the rat brain but carbimazole treatment reduced 5-HT and glutamate content in this area of the rat brain. Similarly, cortical content of 5-HT and histamine also increased following L-thyroxine administration whereas carbimazole treatment lowered 5-HT, histamine and glutamate levels. Simultaneously, there was a considerable rise in the circulating levels of T3 and T4 in L-thyroxine-treated rats and a marked reduction in their levels in carbimazole-treated rats. There is a positive correlation between these amines and the thyroid hormone level. Thus, the results suggest that L-thyroxine and carbimazole administration cause marked alteration in biogenic amines and amino acids in rat brain, which may have an important role in the functioning of thyroid gland. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Etiological profile of short stature
(The Indian Journal of Pediatrics, 2003) S.K. Bhadada; N.K. Agrawal; S.K. Singh; J.K. Agrawal
Objective: To study the frequency of various causes of short stature and their etiological contribution in a referral endocrinology and metabolism clinic at a tertiary care hospital. Methods: 352 children with growth retardation attending endocrine clinic between Feb 1999 to Mar 2001 were investigated for etiology of short stature. Agrawal's growth chart was used for percentiles and height velocity. Various relevant radiological, biochemical and hormonal investigations were performed. Results: Normal variant short stature was the most common cause of short stature followed by endocrine causes. Conclusion: In males most common cause of short stature was constitutional growth delay, while in females most common cause of short stature was familial short stature.
Familial childhood parathyroid adenoma
(1994) Madhukar Rai; J.K. Agrawal; V. Sasikumar; S.K. Singh; S.K. Saraf; Mohan Kumar; H.S. Shukla
A family in which both the father and son had parathyroid adenoma in childhood is presented, along with a brief review of the literature. © 1994.
Fine needle aspiration cytology in the management of acute suppurative thyroiditis
(Medquest Communications LLC, 1994) S.K. Singh; J.K. Agrawal; M. Kumar; H.S. Shukla
Acute suppurative thyroiditis (AST) is relatively uncommon. We report 11 such cases from a population residing in a goiter endemic zone of Northern India. The important contribution of fine needle aspiration cytology in confirming the diagnosis and management is emphasized.
Glucose tolerance studies in lichen planus
(1987) P.K. Nigam; Lata Sharma; J.K. Agrawal; Gurmohan Singh; S.K. Khurana
A study of glucose tolerance and insulin response to oral glucose was carried out in 56 consecutive histologically confirmed cases of lichen planus. 30.3% patients showed abnormal glucose tolerance. The pattern of insulin response was similar to that seen in type 11 diabetes. Insulin/glucose ratio showed the same relationship as seen in type II diabetes. These results reinforce the possibility of glucose intolerance in lichen planus patients. However, no correlation between glucose tolerance abnormalities and duration and distribution of lesions was observed. © 1987 S. Karger AG, Basel.
Glucose tolerance test in leprosy
(1990) R. Garg; J.K. Agrawal; H.S. Bajpai; G. Singh; P.K. Srivastava
[No abstract available]